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Antifungal Agents As Neuroprotectants
Provided herein are compounds, compositions and methods for protecting neuronal and glial cells.
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Biosafety Level (bsl)-3 Life Support Cell for Studying Live Animals
A biological safety system includes a life-support cell, a supply system fluidly connected to the life-support cell, and an exhaust system fluidly connected to the life-support cell. The life-support cell is structured to contain a laboratory animal infected with microorganism of a type that require
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Socs-1 Gene Methylation in Cancer
Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In addition, methods of treating a can
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Cancer Immunotherapy with a Viral Antigen-defined, Immunomodulator-secreting Cell Vaccine
A human cell line, which lacks major histocompatibility class I (MHC-I) antigens and major histocompatibility class II (MHC-II) antigens and which has been modified to comprise and express (i) a nucleotide sequence encoding an immunomodulator and (ii) a nucleotide sequence encoding a viral antigen,
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Cancer Stem Cell Expression Patterns and Compounds to Target Cancer Stem Cells
Described herein are therapeutic targets expressed in cancer stem cells and methods for treating and diagnosing cancer by targeting such cells with antibodies, compounds, nucleic acid, or other therapeutic agent. In one embodiment described herein, therapeutic agents for the treatment of cancer are
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Methods for Protecting the Skin from Radiation Insults
The present invention relates to methods and compositions for the protection of skin and mucous membranes from undesirable side effects of ionizing radiation in a patient undergoing ionizing radiation therapy. In particular, the application describes compositions and methods comprising the topical u
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Cytokine Receptor Chain
PROBLEM TO BE SOLVED: To provide a receptor fragment having an affinity to IL-13, a method for producing the same, and the treating use of the same. ; SOLUTION: A polynucleotide having a specific sequence encoding the IL-13 receptor and its fragments, a receptor protein of the IL-13, a method for pr
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Methylated CpG Island Amplification (MCA)
The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethylated PcG sites and contacting the sample with an isoschizomer of the methylation sensitive restrict
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Vertebral Body Reduction Instrument and Methods Related Thereto
Featured is a reduction instrument being configured and arranged to allow correction of vertebral translation and applying distraction across a segment in an independent fashion. Such a reduction instrument embodies one or more identical modules that are configured as needed for correcting the defor
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Target for Therapy of Cognitive Impairment
PROBLEM TO BE SOLVED: To provide a method of identifying a gene associated with a desired behavior in a mammal. ; SOLUTION: The method of identifying a gene associated with the desired behavior in a mammal comprises the steps of: (a) providing a test population of mammals having the desired behavior
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Single Molecule Spectroscopy for Analysis of Cell-free Nucleic Acid Biomarkers
The present invention relates, e.g., to a method for detecting a nucleic acid molecule of interest in a sample comprising cell-free nucleic acids, comprising fluorescently labeling the nucleic acid molecule of interest, by specifically binding a fluorescently labeled nanosensor or probe to the nucle
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Multicomponent Degradable Cationic Polymers
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Pol
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Trioxane Monomers and Dimers
Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, to
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Novel Desmin Phosphorylation Sites Useful in Diagnosis and Intervention of Cardiac Disease
This invention relates to novel phosphorylation sites in the desmin protein that are associated with the onset of heart failure. The phosphorylation sites, i.e., Ser-27 and Ser-31, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subj
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Compositions and Methods for Inactivation of Pathogens At Genital Tract Surfaces
The present disclosure includes compositions and methods of inactivating pathogens of a genital tract of a female. The compositions include L-lactic acid substantially free of D-lactic acid. In particular, an intravaginal ring for sustained release of L-lactic acid out of a reservoir containing mult
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Conversion of Chitin Into N-acetylglucosamine, Glucosamine and Bioethanol
Compositions and methods are provided for converting chitin into N-acetylglucosamine, glucosamine and ethanol. The chitin may be used directly from the environment, for example, as occurs in invertebrate cuticles, fungal cells and/or algae. Mutant bacteria were created by knocking out or inactivatin
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Self-assembly of Lithographically Patterned Polyhedral Nanostructures and Formation of Curving Nanostructures
The self-assembly of polyhedral nanostructures having at least one dimension of about 100 nm to about 900 nm with electron-beam lithographically patterned surfaces is provided. The presently disclosed three-dimensional nanostructures spontaneous assemble from two-dimensional, tethered panels during
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Compositions and Methods for Enhancing Antigen-specific Immune Responses
Methods for treating or preventing recurrence of hyper proliferating diseases, e.g., cancer, are described. A method may comprise priming a mammal by administering to the mammal an effective amount of a nucleic acid composition encoding an antigen or a biologically active homo log thereof and boosti
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Methods of Promoting Muscle Growth
The present invention relates to use of the interaction of myostatin with the activin type II receptors, and more specifically to use of soluble ACVR2 to increase muscle growth in a subject. As such, methods of increasing muscle mass in a subject are provided. In addition, methods of ameliorating th
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Decontamination Apparatus
A decontamination apparatus including an enclosure, a first and second decontamination system within the enclosure where the first and second decontamination systems rely on different methods of decontamination.
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Phosphopeptides As Melanoma Vaccines
We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived from source proteins which may have roles in cancer development, growth and metastasis. Most were e
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Method and Apparatus for Environmental Monitoring and Bioprospecting
A method for environmental monitoring and bioprospecting includes the steps of: (a) utilizing a testing device having: (i) a container having a fluid inlet and outlet, (ii) a plurality of capillary microcosms situated within the container, each of these capillaries having an inlet and outlet that ar
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Methods of Treating Brain Tumors with Antibodies
The application is directed toward a method of treating a brain tumor in a patient comprising systemically administering a monoclonal antibody.
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Parstatin Peptides and Uses Thereof
The invention provides parstatin peptides, particularly a mammalian parstatin peptide including amino acids 1-26 of full length mammalian parstatin, preferably a human parstatin. The invention provides parstatin peptides in appropriate pharmaceutical carriers and formulated for administration. The i
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Leucine-rich repeat kinase (LRRK2) drosophila model for parkinson's disease: wildtype1 (WT1) and G2019S mutant flies
Mutations in the leucine-rich repeat kinase (LRRK2) gene cause late-onset autosomal dominant Parkinson's disease (PD) with pleiomorphic pathology. Previously, we and others found that expression of mutant LRRK2 causes neuronal degeneration in cell culture. Here we used the GAL4/UAS system to generat
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System for Diagnosis and Therapy of Gaze Stability
A system to measure a subject's gaze stability, comprising: a display device; a data processor in communication with the display device; a data input device in communication with the data processor; and a motion detector in communication with the data processor, the motion detector being adapted to
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Hypoxia Induced Mitogenic Factor
We found that FIZZ1/RELM[alpha] is inducible by hypoxia in lung. The hypoxia-upregulated expression of FIZZ1/RELM[alpha] was located in the pulmonary vasculature, bronchial epithelial cells, and type II pneumocytes. Recombinant FIZZ1/RELM[alpha] protein stimulates rat pulmonary microvascular smooth
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Systems, Apparatus and Devices for Use in Animal Studies
Featured are various devices, apparatuses and systems for use in connection with animal studies or experimentation as well as methods related thereto. Such devices, apparatuses and systems include a scalable animal enclosure that is easily customized for a given application; a scalable and easily cu
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Peroral transgastric endoscopic techniques
Methods and apparatus for accessing the peritoneal cavity and for ligation of fallopian tubes. A representative method includes using an endoscope to orally access a gastric wall. The gastric wall is punctured to provide access to a peritoneal cavity. The endoscope is advanced into the peritoneal ca
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Cells for Increased Protein Expression Comprising One Or More Release Factors and Methods of Use
The invention provides recombinant cells or recombinant restrictive cells for overexpressing one or more proteins comprising one or more release factors. The invention also provides methods for producing a recombinant protein comprising culturing the cells of the present invention under conditions s
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Annexina2 As Immunological Target
AnnexinA2 (ANXA2), a member of the Annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. AnnexinA2 is abundantl
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Compositions and Methods for Treating Hepatic Neoplasia
The present invention provides compositions and methods featuring miR-26 microRNA polynucleotides for the diagnosis, treatment or prevention of hepatic neoplasia.
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Compositions and Methods for Diagnosing and Treating Inflammatory Bowel Disease and Related Disorders
The present invention features biomarkers capable of diagnosing inflammatory bowel disease and methods of using such biomarkers to diagnose and selecting treatments for inflammatory bowel diseases.
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Biocompatible Polysaccharide-based Hydrogels
Modified polysaccharides and crosslinked modified polysaccharide compositions are described. Methods of using the crosslinked modified polysaccharide compositions to deliver proteins, oligonucleotides, or pharmaceutical agents are also disclosed.
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A System and Method for Patient Self-assessment Or Treatment Compliance
A system and method for transmission of alphanumeric messaging between mobile subscribers and an external system to send messages directly to the mobile subscriber's existing mobile phone to query them, for example, on the psychometric scale of interest. The resulting daily assessments may then be s
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Detecting and Sorting Methylated Dna Using a Synthetic Nanopore
Provided are methods for detecting, characterizing or separating DNA based on methylation. Heterogeneous DNA populations are separated based on DNA methylation by providing a membrane having a nanopore through which an electric field is applied. DNA of interest is introduced, and for a given thresho
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Compositions for Promoting Epigenetic Dna Demethylation and Methods of Use Therefore
The invention features compositions and methods for modulating the expression of Gadd45 and the use of such compositions and methods as neuroprotectants, to enhance neurogenesis, and for the treatment of mood disorders.
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Inhibitors of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto
The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
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Immunotherapy for Contact Dermatitis Using Co-signal Regulation
Compounds, compositions and methods for immunotherapy in contact dermatitis. Compounds and compositions (e.g. monoclonal antibodies) that stimulate the LAIR-1 expression pathway in LAIR-1 expressing immune cells and are useful for preventing or treating contact dermatitis are provided.
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A System for Registration and Information Overlay on Deformable Surfaces from Video Data
A surgical system including an optical imaging device arranged to image an internal structure of a subject under observation, a processor in communication with the optical imaging device, and a visual display in communication with the processor. The optical imaging device provides a first image sign
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Mammalian Piggybac Transposon and Methods of Use
The present invention provides mammalian piggyBac transposons and transposases. In particular embodiments, the present inventors have identified hyperactive mammalian piggyBac variants. The mammalian piggyBac transposons and transposases can be used in gene transfer systems for stably introducing nu
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Method for the Diagnosis of Age-associated Vascular Disorders
Methods for determining if a subject has or is susceptible to having an age- associated vascular disorder are disclosed. The method includes determining if the subject exhibits altered expression of a product of one or more of the genes listed in Table 1 relative to a control level of expression of
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A Novel in Vitro Hiv-1 Latency Model for Screening Reactivation Agents of Hiv-1
In one aspect, the present invention provides an isolated Bcl-2-transduced cell that comprises, integrated into the genome of the cell, a transcription-competent immunodeficiency virus or a transcription-competent immunodeficiency virus-based retroviral vector. Under basal in vitro culture condition
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Piggybac Transposon Variants and Methods of Use
The present invention provides hyperactive piggyBac transposons, in particular hyperactive piggyBac transposons from Trichoplusia ni (cabbage looper moth) that transpose at a higher frequency than wildtype. The invention also features integration defective piggyBac transposons. The piggyBac transpos
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Compositions and Methods for Ex Vivo Hepatic Nucleic Acid Delivery
The invention provides compositions and methods for delivery of nucleic acids to the liver ex vivo. The method includes slow, low pressure infusion of the nucleic acid into the liver to efficiently transduce cells with minimal cell damage.
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Phenazine Derivatives and Uses Thereof
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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N-hydroxylsulfonamide Derivatives As New Physiologically Useful Nitroxyl Donors.
The invention relates to N-hydroxylsulfonamide derivatives for formula (I), (II) or (III), in which the variables are as defined in the claims, that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or condition
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Cancer Treatment with Gama-secretase Inhibitors
Provided are methods for treating cancer in a patient, comprising administering to a patient in need thereof a therapeutically effective regimen, the regimen comprising administering a gamma-secretase inhibitor, wherein the regimen results in a reduction in the cancer cell population in the patient.
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Gas Syringe Device
PROBLEM TO BE SOLVED: To provide a unit dose, gas-filled syringe which is filled with gas and packaged in a gas barrier material prior to use to increase shelf-life, that is, to minimize gas leakage and dilution of the contents of the syringe. ; SOLUTION: The syringe (12) is filled with a selected g
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Ablation Based Laser Machining of Biomolecule Patterns on Substrates
A method for patterning a one or more biomolecules on a substrate that includes coating the substrate with a coating of the one or more biomolecules, applying a laser to the coating, and ablating a portion of the one or more biomolecules with the laser in a predetermined pattern.
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Magnetic Tweezers Method to Measure Single Molecule Torque
A system and a method for determining the torque imposed on a filament, such as a single DNA strand or macromolecule, using a magnetic probe and an imaging device.
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Use of Protein Tyrosine Inhibitor Such As Genistein in Treating Diabetic Retinopathy Or Ocular Inflammation
PROBLEM TO BE SOLVED: To provide a method for prophylactically and therapeutically treating diabetic retinopathy and a method for prophylactically and therapeutically treating ocular inflammation. ; SOLUTION: Administration of an inhibitor of the protein tyrosine kinase pathway to an animal (e.g. a
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Device and Method for Preparing and Performing Multiple Polymerase Chain Reactions
The present invention relates to methods, kits and devices with multiple open reaction chambers having multiple pre-deposited primer compositions, and a basic sample loading mechanism that utilizes an immiscible companion fluid for preparing and performing multiple Polymerase Chain Reactions
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Recognition of Cyp2e1 Epitopes
A critical epitope of human cytochrome P4502E1 (CYP2E1) associated with the development of hepatic autoimmune disease, including methods and kits for diagnosis and prognosis using the critical epitope as a biomarker for hepatic autoimmune disease.
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Ovarian Cancer Methylome
The present invention provides methods and kits for identifying a cell that exhibits or is predisposed to exhibiting unregulated growth by detecting hypermethylation of a gene or a regulatory region in at least one gene in the cell. Also provided are methods for diagnosis or prognosis of ovarian can
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Method and Kit for the Ex Vivo Evaluation of the Response of a Tumor to Conditions to Be Tested
The invention concerns a method and kit for the ex vivo evaluation of the response of a tumor to conditions to be tested, in particular a tumor treatment regime, in an isolated tumor sample. The diagnostic method is suitable for the use in medicine and in pharmacy, in particular for the pretherapeut
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Method for the Sensitive Detection of Polyamino Acids and Other Macro-molecules
The invention relates to a method for the detection of an analyte containing polyamino acid. The object of the invention is to detect polyamino acids in a highly sensitive manner. The object is achieved in that an LM is coupled to a protein after chemical activation, and is complexed using a lanthan
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Method of Generating ?0 Cells
Described is a method of the generation of ? DEG cells using a mitochondrial targeted restriction endonuclease. This method comprises (a) transfecting cells with an expression vector containing a gene encoding a fusion protein comprising a mitochondrial targeting sequence (MTS) and a restriction end
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Dynamic reconfigurable memory hierarchy
A cache and TLB layout and design leverage repeater insertion to provide dynamic low-cost configurability trading off size and speed on a per application phase basis. A configuration management algorithm dynamically detects phase changes and reacts to an application's hit and miss intolerance in ord
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Apparatus and Method for Cone Beam Volume Computed Tomography Mammography
Volume tomographic mammography is performed with a gantry frame (206) in which a cone-beam radiation source (210) and a thin-film detector (208) are mounted. The patient (P) rests on an ergonomically designed table (202) with a hole (204) to allow one breast (B) to extend therethrough such that the
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Compositions and Methods Relating to Detection of Soluble E-cadherin in Neurodegenerative Disease
Disclosed herein are compositions and methods for diagnosing, detecting, or monitoring neural disease, conditions, or disorders involving detection of soluble E- cadherin.
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High-frequency Oscillatory Ventilation Monitoring Method and System
A method of monitoring high frequency oscillatory ventilation (HFOV) wherein the oscillatory movement of the chest wall of an individual is measured. An average amplitude is determined and compared to a pre-determined baseline amplitude, which is established by using the average amplitude at a parti
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Methods of Treating Inflammatory Intestinal Disease and Managing Symptoms Thereof
Methods and products are disclosed for treating an inflammatory intestinal disease in a mammalian subject in need thereof, or preventing or reducing a symptom of inflammatory intestinal disease. These method include administering to the subject a therapeutically effective dose of (i) an isolated Avr
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Methods of Treating B-cell Cancers
The present invention is directed to methods of causing malignant B-cells and treating malignant B-cells. These methods involve the use of an inhibitor of PKK activity, whether active directly against PKK or effective to knockdown PKK expression, which when introduced into a malignant B cell (or adm
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Method for Modifying the Refractive Index of Ocular Tissues
A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) di
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Tumor Suppression Through Plexin C1
Disclosed are compositions and methods relating to Plexin C1 and diagnosing, treating, and evaluating treatment for cancer.
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Apparatus and method for cone beam volume computed tomography breast imaging
Cone beam volume CT breast imaging is performed with a gantry frame on which a cone-beam radiation source and a digital area detector are mounted. The patient rests on an ergonomically designed table with a hole or two holes to allow one breast or two breasts to extend through the table such that th
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Treating Myelin Diseases with Optimized Cell Preparations
The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.
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Enhancing Gene Transfer
Described herein are methods of improving the efficiency of gene transfer for a wide range of applications. Specifically provided are methods of increasing expression of an exogenous gene in a cell by contacting the cell with a vector comprising the exogenous gene and contacting the cell with a prot
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Fibroblast Growth Factor (fgf) Analogs and Uses Thereof
The invention relates to novel peptide comprising FGF-P and methods of use thereof.
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Transcutaneous Magnetic Energy Transfer Device
Transcutaneous magnetic energy transfer to drive a VAD or other implanted medical device can be supplied through two spinning (or otherwise moving) permanent magnets, or a moving permanent magnet and a moving ferric material, or a moving permanent magnet and a coil or an array of coils, One part is
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Thioredoxin Interacting Protein (TXNIP) As Regulator of Vascular Function
The present invention relates to screening assays for the identification of agents that can modify the interaction of thioredoxin interacting protein (TXNEP) on thioredoxin (TRX)5 preferably by inhibiting TXNIP downregulation of TXR. The use of such compounds, including the disclosed siRNA and antib
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System and Method for Hardware Acceleration of a Software Transactional Memory
In a transactional memory technique, hardware serves simply to optimize the performance of transactions that are controlled fundamentally by software. The hardware support reduces the overhead of common TM tasks-conflict detection, validation, and data isolation-for common-case bounded transactions.
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Psa and Klk2 As Therapeutic Targets and Molecules Inhibiting Psa and Klk2
Disclosed herein are compositions and methods relating to prostate-specific antigen (PSA), KLK2 and androgen receptor. Further provided are methods and compositions for inhibiting PSA and/or KLK2 activity. Further provided are compositions and methods for treating or preventing cancer.
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Robotic Localizing Aid for High Intensity Focused Ultrasound Delivery
A holding structure holds a biopsy needle and a HIFU transducer to allow smooth and accurate delivery of the HIFU beam at the interface of the liver, where bleeding will occur. This manipulator structure performs the biopsy and HIFU through the percutaneous approach. In addition, the procedure is im
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Production of Human Papillomavirus Capsid Protein and Virus-like Particles
The present invention is directed to a method of expressing the papillomavirus capsid protein coding sequence in a cell using an expression system under conditions facilitating expression of the protein in the cell. In another aspect of the invention, it has been discovered that virus-like particle(
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Respiratory Disease Monitoring System
An automated system for monitoring respiratory diseases, such as asthma, provides noninvasive, multimodal monitoring of respiratory signs and symptoms that can include wheeze and cough. Some embodiments employ a mobile device, such as a cell phone, in which raw data from a microphone and an accelero
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Compounds and Methods for Altering Lifespan of Eukaryotic Organisms
Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1
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Risk Stratification of Genetic Disease Using Scoring of Amino Acid Residue Conservation in Protein Families
Methods, databases and software for determining the risk of an adverse health event for patient by analysis of the protein sequence of the patient are described. The methods involve obtaining a protein sequence that is associated with a specific disorder from the patient. The protein sequence from t
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Enhancing the Therapeutic Effect of Acupuncture with Adenosine
The present invention relates to a method of improving the therapeutic effect of acupuncture in a subject. The method involves administering adenosine, an adenosine mimetric, an adenosine modulator, an adenosine transport inhibitor, enzymes involved in adenosine metabolism, and/or an adenosine recep
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Low-cost Device for C-scan Photoacoustic Imaging
The prostate gland or other region of interest is stimulated with laser light, resulting in ultrasound waves (photoacoustic effect) which are focused by an acoustic lens and captured by a specific 1- or 2D sensor array and subsequently displayed as a C-scan on a computer screen. The amplitude of the
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Compositions that inhibit proliferation of cancer cells
The present invention relates to compositions and methods for reducing the proliferation of cancer cells through targeted interactions with integrin.
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Photoacoustic Imaging Using a Versatile Acoustic Lens
To image various soft tissues in the body using pulsed laser optical excitation delivered through a multi-mode optical fiber to create photoacoustic impulses, and then image the generated photoacoustic impulses with an acoustic detector array, a probe includes either a mirror and an acoustic lens or
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Soluble Low-density Lipoprotein Receptor Related Protein Binds Directly to Alzheimer's Amyloid-beta Peptide
A soluble derivative of low-density lipoprotein receptor related protein-1 (sLRP-1) binds directly to Alzheimer's amyloid-[beta] peptide (A[beta]). This binding may be used to detect A[beta] or to separate A[beta] from the rest of a subject's body. In Alzheimer's disease, it may be used to provide d
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Methods of Diagnosing and Treating Fibrosis
The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibro
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Preventing and Treating Sepsis
Provided are polypeptides comprising a variant activated protein C comprising one or more amino acid substitutions selected from the group consisting of K146R, D172N, C212R, K146G, R147G, R177G and combinations thereof. Also provided are nucleic acids encoding the polypeptides, and cells, compositio
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Method and Apparatus of Cone Beam Ct Dynamic Imaging
A cone-beam scanning system scans along a half circle. The reconstruction uses a weighting function which decreases for rows farther from the scan plane to take the redundancy of the projection data into account. Another embodiment uses a circle plus sparse helical scan geometry. Image data can be t
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Mlk Inhibitors and Methods of Use
Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating dis
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Animal Model for Osteoarthritis and Intervertebral Disc Disease
Provided herein is a transgenic animal whose genome comprises a first nucleic acid sequence encoding a fusion polypeptide, wherein the fusion polypeptide comprises a Cre recombinase and a mutated ligand binding domain of human estrogen receptor (CreER), wherein the first nucleic acid is operably lin
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Systems and Methods for Enhancing Vaccine Efficacy
Pharmaceutical compositions of the invention include an antigen or a nucleic acid molecule encoding the antigen; one or both of a PPAR ligand and an RxR ligand; and a pharmaceutically suitable carrier. The pharmaceutical composition can optionally include a mitogen or other additives. Also disclosed
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Hybrid Host Materials for Electrophosphorescent Devices
Compounds (including polymers) for use in hybrid host materials which can be used in electroluminescent devices. The compounds comprise at least one electron- transporting moiety and at least one hole-transporting moiety which are joined by a flexible linker. Hybrid host materials comprising the com
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Compositions and Methods for Inhibiting G Protein Signaling
Disclosed are compositions and methods for treating diseases associated with G protein [beta][gamma] subunit activity.
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Spatially Inhomogenously Functionalized Porous Media and Method for Use in Selective Removal of Contaminants
Compositions and methods for separating double-stranded nucleic acids out of a mixture comprising single-stranded nucleic acids and/or dNTPs and/or enzymes. The method uses spatially inhomogenously functionalized nanoporous materials. For example, the compositions and methods of the present inventio
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Aberration Control By Corneal Collagen Crosslinking Combined with Beam-shaping Technique
Corneal collagen crosslinking is used to alter a characteristic of the cornea, such as thickness or refractive index, to correct wavefront aberrations, including higher-order aberrations. A scanning laser or the like is used to perform the corneal collagen crosslinking by locally altering the optica
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Semiconductor Device and Method
The present invention is directed to a semiconductor device that includes at least one p-n junction including a p-type material, an n-type material, and a depletion region. The at least one p-n junction is configured to generate bulk photocurrent in response to incident light. The at least one p-n j
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Methods of Modifying P53 Acetylation and Treating Cancer Using Avra
The present invention relates to methods and compositions for the treatment of cancer. The methods and compositions involve the use of the Salmonella effector protein AvrA, as well as variants or fragments thereof, or encoding nucleic acids. The AvrA effector protein is demonstrated to enhance p53 a
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Methods and Apparatus for Differential Phase-contrast Fan Beam Ct, Cone-beam Ct and Hybrid Cone-beam Ct
A device for imaging an object, such as for breast imaging, includes a gantry frame having mounted thereon an x-ray source, a source grating, a holder or other place for the object to be imaged, a phase grating, an analyzer grating, and an x-ray detector. The device images objects by differential-ph
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Automated Placental Measurement
A method for analyzing the placenta in two or three dimensions comprising: selecting one or more placenta! samples to be analyzed; obtaining a digital image of each placenta! sample: and performing an analysis on the digital images, wherein a mathematical algorithm is applied to the digital image, T
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Needle Shield for Injections
A needle shield for hiding a needle from a patient during an injection is disclosed. The needle shield comprises an attaching portion for attaching the needle shield to a syringe and an opaque collapsible element extending from the attaching portion, the collapsible element having an orifice extendi
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Ultrasound Technology to Control the Spatial Organization of Cells and Proteins in Engineered Tissues
The present invention is directed to methods of inducing spatial organization of cells an in vitro culture system using ultrasound technology. The invention is further directed to methods of inducing extracellular matrix remodeling and neovessel formation in an in vitro culture system and generating
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