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Carbon Nanotubes Grown on Nanostructured Flake Substrates and Methods for Production Thereof
Carbon nanotubes grown on nanostructured flake substrates are disclosed. The nanostructured flake substrates include a catalyst support layer and at least one catalyst layer. Carbon nanotubes grown on the nanostructured flake substrates can have very high aspect ratios. Further, the carbon nanotubes
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Neat Carbon Nanotube Articles Processed from Super Acid Solutions and Methods for Production Thereof
Articles comprising neat, aligned carbon nanotubes and methods for production thereof are disclosed. The articles and methods comprise extrusion of a super acid solution of carbon nanotubes followed by removal of the super acid solvent. The articles may be processed by wet- jet wet spinning, dry-jet
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Water-soluble Carbon Nanotube Compositions for Drug Delivery and Medical Applications
Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for mak
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Vertically-stacked Electronic Devices Having Conductive Carbon Films
Vertically-stacked electronic devices having conductive carbon films are disclosed. The vertically-stacked devices exhibit non-linear current-versus-voltage response over a voltage sweep range in various embodiments. The vertically-stacked devices may be assembled into arrays where the vertically-st
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Water-soluble Carbon Nanotube Compositions for Drug Delivery and Medicinal Applications
Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for mak
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Electronic Switching, Memory, and Sensor Devices from Carbon Sheets on Dielectric Materials
Electronic devices comprising a dielectric material, at least one carbon sheet, and two electrode terminals are described herein. The devices exhibit non-linear current-versus-voltage response over a voltage sweep range in various embodiments. Uses of the electronic devices as two- terminal memory d
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Treatment and Diagnostic Methods for Fibrosis Related Disorders
The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful
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Fast wavelength tuning techniques for external cavity lasers
An apparatus comprising a laser source configured to emit a light beam along a first path, an optical beam steering component configured to steer the light beam from the first path to a second path at an angle to the first path, and a diffraction grating configured to reflect back at least a portion
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Resonant Optothermoacoustic Detection of Optical Absorption
A device comprising an acoustic detector, one or more thermal sensing elements coupled to the acoustic detector, and a light source. A method comprising directing a beam of light at a wavelength at or near one or more thermal sensing elements, wherein the thermal sensing elements are coupled to an a
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Functionalized, Hydrogen-passivated Silicon Surfaces
This invention is generally related to a method of making a molecule-surface interface comprising at least one surface comprising at least one material and at least one organic group wherein the organic group is adjoined to the surface and the method comprises contacting at least one organic group p
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Measurement of pipe wall thickness using magnetic flux leakage signals
An apparatus comprising a processor configured to implement a method comprising obtaining a pipe profile comprising a diameter, a nominal thickness, and a material, receiving a magnetic flux leakage (MFL) indication for a pipe associated with the pipe profile, and determining a wall thickness for th
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Method for Nanoencapsulation
Methods of nanoencapsulation are described herein. Embodiments of the method utilize the coacervation of a cationic polyelectrolyte with an anionic polyelectrolyte to form a novel capsular matrix. In particular, the novel methods may be used to encapsulate a suspension of a hydrophobic material such
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Methods of Fabricating Enhanced Tissue-engineered Cartilage
Compositions and methods for fabricating a tissue-engineered cartilage construct comprising: providing a cell sample comprising a plurality of chondrocytes; culturing the cell sample to produce a tissue-engineered cartilage construct; and treating the tissue-engineered cartilage construct, wherein t
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Methods for Solubilizing and Separating Large Fullerenes
We have discovered that size dependent solubility of large fullerenes in strong acids is dependent on acid strength. This provides a scalable method for separating large fullerenes by size. According to some embodiments, a method for processing a fullerene starting material comprises large fullerene
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Carbon Nanotube Compositions and Methods for Production Thereof
Compositions comprising at least one type of carbon nanotube, at least one surfactant, and at least one polymer are disclosed. The compositions provide stable fluorescence over a wide range of pH in various embodiments. In some embodiments, the compositions are biocompatible. Methods for preparing t
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Therapeutic Compositions and Methods for Delivery of Active Agents Cleavably Linked to Nanoparticles
Various embodiments of the present invention pertain to therapeutic compositions that comprise: (1) an active agent (e.g., paclitaxel); and (2) a nanoparticle (e.g., gold nanoparticle). In such embodiments, the active agent is covalently linked to the nanoparticle through a cleavable linker (e.g., a
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Conformal Coating on Nanostructured Electrode Materials for Three-dimensional Applications
A fabrication process for conformal coating of a thin polymer electrolyte layer on nanostructured electrode materials for three-dimensional micro/nanobattery applications, compositions thereof, and devices incorporating such compositions. In embodiments, conformal coatings (such as uniform thickness
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Nanostructure-beta-blocker Conjugates
Nanostructure-beta-blocker conjugates are provided. Additionally, methods of synthesizing nanostructure beta-blocker conjugates and their use in the treatment and prevention of bone disease, such as osteoporosis, are also provided.
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Dendrimers for Sustained Release of Compounds
Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.
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Method of delaminating aggregated particles with a coating agent in a substantially supercritical fluid
The present invention involves a method of delaminating aggregated particles of natural silicate, nanoplatelet, nanofiber, or nanotube structures. The method comprises diffusing a coating agent in a substantially supercritical fluid between the aggregated particles and catastrophically depressurizin
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Methods and Catalysts for Making Biodiesel from the Transesterification and Esterification of Unrefined Oils
A method of forming a biodiesel product and a heterogeneous catalyst system used to form said product that has a high tolerance for the presence of water and free fatty acids (FFA) in the oil feedstock is disclosed. This catalyst system may simultaneously catalyze both the esterification of FAA and
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Anti-cancer Therapeutic Strategy to Overcome Cancer Resistance and to Enable Tailoring Treatment to Patients
A gene construct comprising a programmed-cell-death executioner gene having a nuclear localization signal, a deleted signal peptide, an actin-resistant binding site, a promoter, and an activator. A method of making a gene construct, by modifying a programmed-cell-death executioner gene by adding a n
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Compositions and Methods for Detecting and Modulating Cell Death By a Translation Regulated Gene Expression System
The technology relates to a nucleic acid expression cassette comprising a TR element encoding an mRNA molecule that is translated in stressed and/or dying cells, and a nucleotide sequence operably linked to the TR element, that is a first open reading frame (ORF) sequence and encodes a polypeptide o
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Polyclonal Bispecific Antibody Compositions and Method of Use
The invention relates to compositions and methods for treating a host infected with a pathogen. The composition comprising a population of polyclonal bispecific binding molecules that can target and eliminate a host cell infected with the pathogen. Methods for activating and arming cytotoxic immune
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A Method for the Formation of Megamitochondria
The present invention relates to an in-vitro method for the formation of megamitochondria in cells, wherein the cells are grown in a suitable fermentation medium acidulated with lactic acid to pH values between 5.3 and 6.7. The invention further concerns H+ ionophores, ionophores which catalyze the
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Transparent Rectifying Metal/metal Oxide/semiconductor Contact Structure and Method for the Production Thereof and Use
The invention relates to transparent rectifying contact structures for application in electronic devices, in particular appertaining to optoelectronics, solar technology and sensor technology, and also a method for the production thereof. The transparent rectifying contact structure according to the
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Device for Collection and Preservation of Tissue Or Stool Samples
An arrangement for collecting a tissue or stool sample has a sample vial and a source of preservative fluid. A fluid valve controls a flow of the preservative fluid from the source of preservative fluid to the sample vial. An air equalization vent tube is coupled to the source of preservative fluid
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Development of a High Strength High Toughness Bainitic Steel
A bainitic steel with simultaneous high yield strength and high fracture toughness includes at least 5 volume percent austenite as well as iron, carbon, and silicon. The silicon is present in an amount of at least 1.5 weight percent of total weight of the bainitic steel. A method of forming the stee
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Antitumor Agents
The invention provides compounds of formula I as described herein wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, inter
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Promotion of Peroxisomal Catalase Function in Cells
The molecular mechanisms of peroxisome biogenesis have begun to emerge; in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-related changes in peroxisomes of human cells and showed that aging compromises peroxisomal targetin
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New Rac1 Inhibitors As Potential Pharmacological Agents for Heart Failure Treatment
The present invention finds application in the field of medicine and, in particular, to new compounds particularly active in inhibiting Rac1 member of the Rho family. Pharmaceutical preparations containing them useful for the treatment and/or prevention of heart failure are disclosed as well.
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Process for the Preparation of Cyclodextrins Composed of More Than Eight Glucose Units
A process for the preparation of large-ring cyclodextrins (LR-CD) with a degree of polymerisation (DP) of 9 - 21 from starch is described. LR-CD are obtained in a biocatalytic process in high yields by controlling the temperature and reaction time. The LR-CD mixtures obtained are separated from gluc
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Vector(s) Containing an Inducible Gene Encoding a Cdk4/cdk6 Inhibitor Useful for Treating Neurodegenerative Disorders Or Diseases Associated with an Unscheduled Activation of the Cell Cycle
Described are vectors containing (a) a gene encoding (i) a CDK4/CDK6 inhibitor, preferably p16INK4a, or (ii) an RNA interfering with CDK4 and/or CDK6 expression and/or activity, under the control of an inducible promoter and (b) a gene encoding a transactivator protein for said promoter useful for t
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Aurora Kinase Inhibitors Compounds.
The present invention relates to novel compounds of formula (I) that inhibit cell proliferation, in particular by inhibiting selectively Aurora A kinase activity and to their use in medicine, in particular for treating, ameliorating or preventing hyperproliferative diseases. The invention further re
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Modular System of Functional Units for Mixing, Processing And/or Separating Samples for Use in Biological/medical Research and for Diagnostics
Basic steps of biological research and of diagnostics include mixing, physical and/or chemical reactions and separation. Particularly in research task-specific laboratory systems are required which are not commercially available due to small batch sizes and the specific problems to be faced. Because
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Method and Means for Activating Memory B Lymphocytes
The invention relates to a method and means for activating memory B lymphocytes, in particular for use in immunological research and in medicine. For the inventive method, the cells are treated with an activating reagent containing pokeweed mitogen, CpG oligonucleotides, IL-2 and IL-10. It is surpri
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New vaccine strains having two or three different attenuation active metabolic drift mutations, which result in smaller colonies with corresponding longer generation time and correlated attenuation de
Vaccine strains having two or three different attenuation active metabolic drift mutations, which result in smaller colonies with correspondingly longer generation times and correlated attenuation degree, with respect to reduced growth intensity, against the respective wild strains, are new. An inde
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Homogeneous distribution of cellular suspension in porous carrier material for tissue engineering under using molded body with chamber having opening, comprises introducing the carrier material provid
The process for homogeneous distribution of a cellular suspension in a porous carrier material (3) for tissue engineering under using a molded body (1) with a chamber (2) having an opening for receiving the carrier material, comprises introducing the carrier material provided for colonization into t
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Pharmaceutical Agent for the Treatment of Fertility and Gestation Disorders, Immunological Diseases, and Transplantation for Use in Veterinary Medicine, Particularly in Horses, and Methods for the Pro
The invention relates to pharmaceutical agents for the treatment of fertility and pregnancy disorders, and immunological diseases (autoimmune diseases) and transplantation, and a method for the production thereof for use in veterinary medicine, particularly in horses. According to the invention, a p
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Method for locally modifying the elasticity of a substrate designed for the growth of cells thereon
The present invention describes a method for locally modifying the elasticity of an elastic substrate (1) designed for the growth of living cells thereon and/or therein, comprising: emitting laser radiation (2a) by a laser (2), locally depositing energy in at least one designated spatial area locate
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Transmitter/receiver Antenna for Mr with Improved Decoupling Between Antenna Elements
The invention relates to a magnetic resonance tomograph having a magnetic resonance system comprising at least two high-frequency transmitting/receiving units.
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Use of the Opposite Cell Differentiation Program (ocdp) for the Treatment of Degenerated Organs in the Pathological State
The present invention relates to a method for the treatment of organs which are degenerative and /or in the pathological state by means of the use of cells, which are phenotypically stably differentiating or differentiated but not necessarily ultimately predetermined with respect to development, fro
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Cell culture medium and method for culturing stem cells and progenitor cells
The invention relates to a stem cell culture medium that is deficient in both glucose and inositol. As expected most cells die rapidly as in media deficient in both glucose and inositol. However, in particular somatic stem cells and germ line stem cells are surprisingly capable of survival and growt
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Medicament for Treating Problems Relating to Fertility and Pregnancy, and Autoimmune Diseases, and for Inducing an Immunological Tolerance in Transplant Patients, and Method for Producing Said Medicam
A medicament for treating pregnancy disorders or for inducing an immunological tolerance in patients with autoimmune diseases or transplantation processes, contains at least one each of a) a precursor hCG beta subunit of the human choriongonadotropine (hCG) selected from hCG beta6 according to SEQ I
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Extracorporeal Organ Conservation
The invention relates to an arrangement for extracorporeal organ conservation. Said type of arrangements are used to artificially preserve or to regenerate vital functions of organs, said organs also having extremities and tissue lobes. The inventive arrangement for extracorporeal organ conservation
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Arrangement for determination of intraorbital pressure, designed in shape of goggles joined to appropriate devices
When the intraocular pressure rises there is only a minimal. backwards motion possible for the socket to give way, which is not sufficient to solve the problem. A chamber with a hermetically closed expansion space at the front is connected with tubes fitted with valves (UV) to a compressor (KP), an
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Titanium Dioxide Thin Film Systems and Method of Making Same
A method for producing a thin film titanium dioxide is disclosed. The disclosed method for producing the thin film titanium dioxide includes performing a magnetron reactive sputtering process to vaporize at least portions of a titanium source in a sputtering chamber that is supplied with gaseous oxy
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Calcium and Lanthanum Solid Base Catalysts for Transesterification
In one aspect, a heterogeneous catalyst comprises calcium hydroxide and lanthanum hydroxide, wherein the catalyst has a specific surface area of more than about 10 m2/g. In another aspect, a heterogeneous catalyst comprises a calcium compound and a lanthanum compound, wherein the catalyst has a spec
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Vaccines Targeting Cellular Death Receptors
The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells within the host's body. The therapeutics are vaccine compositions, including genetic vaccines encoding dea
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Engineering Porous Particles of Water Soluble Therapeutics for Pressurized Metered-dose Inhaler Formulations
The subject matter disclosed herein relates to methods for engineering porous particles of water soluble therapeutics with enhanced physical stability and aerosol characteristics in hydrofluoroalkane (HFA)-based pressurized metered-dose inhaler (pMDI) formulations.
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Ubiad1 Gene and Hyperlipidemia
The disclosure relates to genetic mutations in UBIAD1 gene that segregate with Schnyder's crystalline corneal dystrophy. The disclosure provides methods for detecting such mutations as a diagnostic for Schnyder's crystalline corneal dystrophy either before or after the onset of clinical symptoms. Al
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GALECTIN-3 nsSNP MARKER FOR CANCER
A diagnostic biomarker including a mechanism for determining a patient's propensity to develop cancer. A diagnostic kit for determining a patient's propensity to develop cancer. A method of predicting both a patient's and a population's propensity to develop cancer, by detecting the presence of an H
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Non-Natural Peptides as Models for the Development of Antibiotics
Described herein are methods of screening one of the RNA hairpins in the small ribosomal subunit of bacteria to identify peptides that bind to it. The RNA hairpin target may be the 970 loop (aka helix 31 (h31)) or a modified version thereof. The identified peptides may inhibit protein synthesis and,
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Method for Identifying a Subpopulation of Mammalian Cells with Distinctive Ribosome Translation Profiles
The present invention generally relates to subpopulations of mammalian cells with distinctive ribosome translational profiles, i.e. translational activities. The present invention further relates to methods for identifying and isolating such cells, kits comprising the same, or methods which utilize
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Supported Catalyst Systems and Method of Making Biodiesel Products Using Such Catalysts
A heterogeneous catalyst system, a method of preparing the catalyst system and a method of forming a biodiesel product via transesterification reactions using the catalyst system is disclosed. The catalyst system according to one aspect of the present disclosure represents a class of supported mixed
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Particle-rod Nanostructures
A particle-rod nanostructure is disclosed. The nanostructure comprises an inorganic nanoparticle coated with a capping agent and an organic crystalline rod nucleated on the capped inorganic nanoparticle in a one-dimensional growth pattern.
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Polyamines Useful As Anti-parasitic and Anti-cancer Therapeutics and As Lysine-specific Demethylase Inhibitors
Polyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors of the enzyme lysine-specific demethylase-1.
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Hybrid 2-aminoterailin and aryl-substituted piperazine compounds and their use in altering CNS activity
Hybrid compounds containing an aminotetralin moiety or a heterocyclic and/or open chain analog thereof linked through an alkylene group to an aryl ring system-substituted piperidiene moiety exhibit high levels of CNS activity, in some cases exhibiting especially high relative binding efficiencies be
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Light Therapy Treatment
An exemplary method includes selecting at least one light source configured to generate light at a particular wavelength and applying the light to tissue following an ischemic event. Applying the light to the tissue inhibits cytochrome c oxidase activity. Another exemplary method includes selecting
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Thermally Stable Volatile Film Precursors
A precursor for the deposition of a thin film by atomic layer deposition is provided. The compound has the formula MxLy where M is a metal and L is an amidrazone-derived ligand or an amidate-derived ligand. A process of forming a thin film using the precursors is also provided.
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Cyclic-glur6 Analogs, Methods of Treatment and Use
A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising wherein structure (5), R is a molecular transporter with or without a linker amino acid; R1 is at least about one amino acid covalently bound; and, R2 is isoleucine, leucine, alanine, phenylalanine, or
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3d Soundscaping
A system and method for tracking and tracing motions of multiple incoherent sound sources and for visualizing the resultant overall sound pressure distribution in 3D space in real time are developed. This new system needs only four microphones (although more could be used) that can be mounted at any
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Mass Spectrometry Using Laserspray Ionization
Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 Daltons. The analysis can be solvent-ba
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Automated Video Surveillance Systems
A video surveillance system includes a plurality of video sources, at least one processing server in communication with the video sources, and at least one monitoring station viewing video from the video sources. The video sources are distributed over a target area to be monitored by the surveillanc
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Dendrimer Based Nanodevices for Therapeutic and Imaging Purposes
A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer linked to the compound via a disulfide b
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ZnO NANOPARTICLE CATALYSTS FOR USE IN TRANSESTERIFICATION AND ESTERIFICATION REACTIONS AND METHOD OF MAKING
A method of forming a product, such as a biodiesel product, and a heterogeneous catalyst system used to form said product that has a high tolerance for the presence of water and free fatty acids (FFA) in the oil feedstock is disclosed. This catalyst system may simultaneously catalyze both the esteri
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Wheel assembly with electric power generator
A wheel assembly includes a carrier and a wheel mounted adjacent to the carrier for rotation relative to the carrier. A first array of magnets is carried by one of the first side of the wheel and the carrier, and a first array of coils is carried by the other of the wheel and the carrier correspondi
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Automatic plant watering apparatus
This is an award winning product which is now fully developed for the $1.8bn plant care industry. I am looking for a manufacturer to distribute the product.
An automatic plant watering apparatus is described in which a plant's growing medium is maintained uniformly moist. A one-piece water-holdi
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Omni-directional Angular Acceration Reduction for Protective Headgear
Protective headgear includes an outer shell rotatable relative to an inner shell via a thin layer of elastically and/or plastically yielding material disposed between and secured to the inner and outer shells. The yielding material deforms continuously but non-linearly at least in the tangential or
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Modified Egfr Ectodomain
A protein that attenuates EGFR and/or EGFR family members comprises a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherei
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Multi-sensing Fuel Injection System and Method for Making the Same
A multi-sensing fuel injection system for internal combustion engines. The system includes a fuel injector for injecting fuel into the internal combustion chamber. The fuel injector is electrically insulated from an engine body of the internal combustion engine by way of a first electrically insulat
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Monophosphorylated Lipid a Derivatives
The present invention provides for monophosphorylated lipid A derivatives and carbohydrate derivatives that are useful as agents in the treatment of diseases and conditions, including cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I-IV. In addition
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Check Valve Diaphragm Micropump
A micropump device including a first wafer and a second wafer attached to the first wafer. The first and second wafers are configured to define a chamber therebetween having a predetermined volume. A third wafer is attached to the second wafer to define an inlet section and an outlet section in flui
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Therapeutic Amides
The invention provides compounds of the formula: wherein X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for prep
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Device and Method of Separating and Concentrating Microfluidic Particles
A flow unit for microfluidic particles separation and concentration is disclosed. The unit comprises a nozzle segment, a turn segment, and a diffuser segment. The nozzle segment is defined by a first member and a second member, and has an opening through which fluid and microfluidic particles enter.
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Galectin-3 cleavage as a marker for matrix metalloproteinase activity in cancer
Provided are differential antibodies recognizing the cleaved and non-cleaved forms of matrix metalloproteinases (MMPs), and methods of using the antibodies as surrogate diagnostic markers for the presence of active MMPs in cancer, such as growing breast cancers.
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Enclosed Photobioreactors with Adaptive Internal Illumination for the Cultivation of Algae
The present invention provides an enclosed, internally-lighted bioreactor apparatus, methods for growing photosynthetic microorganisms in the enclosed, internally lighted bioreactor and methods for enhancing growth of a photosynthetic microorganism culture in the enclosed internally-lighted bioreact
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Erythrocyte Atp-release Modulators
Erythrocyte ATP-release modulators and composition and methods for their use to potentiate serum glucose clearance and vasodilation; methods for prophylactic or palliative therapy of glucose processing or vascular disorders; processes for preparing the modulators and compositions comprising them; an
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Biomarkers for Diagnostic and Therapeutic Methods
Erythrocyte ATP-release modulators and composition and methods for their use as biomarkers of glucose processing or vascular disorders, as well as methods for screening to identify to modulators; methods for monitoring efficacy of therapy; and apparatus for use in such methods.
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Antibodies that Specifically Bind Hedgehog-Derived Polypeptides
The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G'CF site recognized by the autoproteolytic domain in the native protein. Also included ar
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Enhanced Surface-selective Spectroscopy Using Broad-band Heterodyne-detected Sum Frequency Generation
Method and apparatus for performing spectroscopy, include the combining of first and second light beams to form a reference beam, focusing the first and second light beams and the reference beam onto a sample, receiving a reflected light beam from the sample at a monochromator, and viewing a predete
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Method for Analyzing Biological Networks
Methods and systems for predicting the significance of a biological pathway in a disease state, the method and system comprising: (a) providing data on the expression levels of a plurality of biomolecules differentially expressed in a disease state as compared with the same biomolecules expressed in
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Nanoparticles for Imaging and Treating Chlamydial Infection
Compositions of nanoparticles and targeting moieties for imaging and treating Chlamydial infection are provided, including nanoparticles conjugated to folic acid and comprising at least one antibiotic effective against Chlamydia.
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Method of Forming Gated, Self-aligned Micro-structures and Nano-structures
Methods of forming a gated, self-aligned nano-structures for electron extraction are disclosed. One method of forming the nano-structure comprises irradiating a first surface of a thermally conductive laminate to melt an area across the first surface of the laminate. The laminate comprises a thermal
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Reduction of Flow-induced Noise in a Centrifugal Blower
A centrifugal blowing apparatus for reducing flow-induced noise is disclosed. The apparatus includes a blower housing having a scroll section formed about a rotational axis and an exhaust section extending from the scroll section. The scroll section includes an opening defining an inlet configured t
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Genus-wide Chlamydial Peptide Vaccine Antigens
Peptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to antigen-binding regions of an anti-idiotypic antibody (mAb2) specific for anti-GLXA antibody (Ab1) which
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2,2-Bis-(hydroxymethyl)cyclopropylidenemethyl-Purines and -Pyrimidines As Antiviral Agents
Compounds which are active against viruses have the following formulas: wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine), 2,6-diamino-purine, 2-amino
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Methods of Treating Cancer with Cd11b Antibodies
Methods and compositions for treating cancer with CD11b antibodies are disclosed. The antibodies may be WT.5 antibodies or compete with WT.5 antibodies, and induce apoptosis in SKOV, MDAH-2774, or BxPC-3 cells
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Method of Making 3-dimensional Neural Probes Having Electrical and Chemical Interfaces
A method of fabricating a three-dimensional neural probe includes the steps of: growing thermal oxide layer; depositing a layer of Au/Cr on the thermal oxide layer; patterning the layer of Au/Cr; depositing a layer of parylene C; etching the thermal oxide layer to release a plurality of islands; and
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Method and Composition for a Protein Transduction Technology and Its Applications
A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection from degradation of the delivered proteins from cellular proteases. A composition for treat proteins has
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Gold (iii) Complexes with Oligopeptides Functionalized with Sulfur Donors and Use Thereof As Antitumor Agents
The invention concerns Au(III) complexes of the type [AuIIIX2(Pdtc)] (X = halogen, pseudo-halogen; pdtc = peptide-/esterified peptidedithiocarbamato) which are able to both maintain the antitumor properties and the lack of nephrotoxic side-effects of the previously reported Au(lll)-dithiocarbamato c
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The Effect of Natural and Synthetic Antioxidants on the Oxidative Stability of Biodiesel
Disclosed are biodiesel fuels with improved oxidative stability. Disclosed are biodiesel fuels which comprise two or more antioxidants which increase the oxidative stability of the biodiesel fuel.
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Activated T Cells
Provided are compositions comprising activated T cells and activated T cells armed with bispecific antibodies directed at cancer antigens which are poor responders to alloantigen, and methods of using the compositions to help engraftment and improve anti-tumor effects.
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Method of Engineering Polar Drug Particles with Surface-trapped Hydrofluoroalkane-philes
The invention relates to a method of engineering polar drug particles with surface-trapped hydrofluoroalkane-philes.
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Co-polymer Stabilizers for Hydrofluoroalkane Dispersions
The use of biodegradable and biocompatible lactide-based nonionic amphiphiles to stabilize a model drug (salbutamol base) dispersion in hydrofluoroalkane (HFA) propellant is disclosed. The results have industrial applicability to the development of HFA-based dispersion pressurized metered-dose inhal
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Neoepitope Detection of Disease Using Protein Arrays
A diagnostic device for and method of detecting the presence of head and neck squamous cell carcinoma (HNSCC) in a patient including a detector device for detecting a presence of at least one marker indicative of HNSCC, the detector device including a panel of markers for HNSCC. A diagnostic device
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Photoinitiated Tissue Filler
Visible light-activated polymer cosmetic filler preparations useful in a variety of applications are provided. In some embodiments, the photo-activated polymer composition comprises a conventional polymeric material, such as HA, together with a modified, cross-linkable polymer, such as PEG or PEODA,
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Vertical Line Hydrophone Array
A hydrophone assembly includes at least four hydrophone units for converting an acoustic signal to an electrical signal, the hydrophone units being in a parallel, cylindrically symmetric spaced spatial relationship with each other, and at least one spacer element to maintain the hydrophone units fix
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Cerebral Vascular Reactivity Monitoring
A monitoring device may include logic to receive arterial blood pressure data associated with a patient and receive tissue hemoglobin data associated with the patient. The logic may also calculate a linear correlation between the arterial blood pressure data and the tissue hemoglobin data. The corre
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Nasal Airway Management Device with Inflatable Supraglottic Laryngeal Cuff
An airway management device such as, for example, an nasal airway management device with inflatable supraglottic laryngeal cuff is provided. The airway management device includes an airway tube, an inflatable cuff, and an inflation passage. The airway tube defines a lumen extending between a proxima
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