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Drug candidate for neurological stroke and septic shock

Summary Apoptosis is a genetically regulated cellular suicide mechanism that plays an important role in regulating normal development and tissue homeostasis as well as pathogenesis of diseases. This process is mediated by one of at least 14 members of the Ced-3/ICE (caspase) family of cysteine prote
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Small Molecule Arrays: a New Forefront in Drug Discovery

Summary Scientists from the laboratory of Professor Stuart Schreiber at Harvard University have developed a novel method of printing small molecule libraries on glass microscope slides. This method represents a next-generation platform for drug discovery. Small Molecule Printing is simple and ef
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High-Throughput Synthetic Platform for Natural Product Analog Libraries

Summary Background: In small molecule drug development, researchers typically develop biased libraries in which all members share a particular characteristic, such as an ability to interact with a particular target ligand or structural features designed to mimic a particular aspect of a class of nat
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Compositions and Methods for Treating Papillomavirus-Infected Cells

Summary Human papillomaviruses have been linked to widespread, serious human diseases, especially cervical carcinoma. Researchers estimate that over 90% of the 500,000 cases of cervical cancer that arise worldwide each year may be linked to HPV. In addition to cervical cancer, papillomaviruses
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Synthesis of Compounds with Peptide Characteristics

Summary Although peptides have shown some promise in clinical trials as therapeutic agents, its success has largely been limited by several factors, including rapid degradation by peptidases, poor cell permeability, and a lack of binding specificity resulting from conformational inflexibility. Over
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Novel Chemistry and Method to make Compounds Active Against Picornaviruses

Summary Picornaviruses are a large family of viruses responsible for many serious human and animal diseases, including hepatitis A, meningitis, diarrhea, summer flu, the common cold and polio. Several candidate antivirals have been shown to bind and inactivate picornaviruses. Current drugs active ag
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Methods and Reagents for Modulating TGF-beta Superfamily Signalling

Summary Harvard Medical School researchers have developed compositions and methods for modulating TGF-b signalling. TGF-b superfamily members regulate a wide range of normal and pathological biological processes, and have been implicated in a variety of developmental and immunological disorders, as
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Antisense Inhibition of Angiogenin Expression in Cancer

Summary Antisense oligonucleotides targeted to anigogenin and designed based on the known sequence of the ANG gene have been synthesized. Angiogenin is a potent positive mediator of neovascularization, a process required for both primary tumor growth and metastasis. Initial immoassay studies showed
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Liposome- Based, Intracellular Delivery of Drugs into Phagocytes, B- and T- cells and their tumor cells.

Summary Liposomes are man-made spheres, or vesicles, with an aqueous interior enclosed by one or more phospholipid bilayers. Liposomes can enhance the pharmacokinetics and efficacy of therapeutics by allowing slow diffusion of a drug through the liposomal membrane, so that the concentration of the d
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A New p53 Cell-Based Assay

Summary Harvard researchers developed a reliable, high-throughput screening assay to identify activators and inhibitors of p53. This cell-based luminescence assay measures the level of a reporter gene product under the control of a promoter containing a p53-binding site. P53 is a transcription fa
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A Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates

Summary Background: Molecular studies of the genomic organization of HIV-1 show that it encodes a number of genes common to all retroviruses, such as the gag, pol, and env genes. The env gene of HIV-1 produces a cleaved envelope glycoprotein (gp120) that is expressed on the exterior viral envelope s
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Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part and parcel of this immune response pathway are the so-called Major Histocompatibility Complex (MHC) molecules.
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Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain

Summary Background: Although peptides have shown some promise in clinical trials as therapeutic agents, their success has largely been limited by several factors, including rapid degradation by peptidases, poor cell permeability, and a lack of binding specificity resulting from conformational inflex
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Toxin-Phage Bacteriocide Antibiotic and Uses Thereof

Summary The rise of antibiotic resistant bacterial strains will necessitate the development of new strategies for treating bacterial infections. One potential alternative to conventional antibiotics is phage therapy - the use of bacteriophage viruses to specifically target and destroy disease-causin
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Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host’s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part and parcel of this immune response pathway are the so-called Major Histocompatibility Complex (MHC) molecu
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Calcipressins: Lead Targets for Autoimmune, Inflammatory, and Cardiovascular Disease

Summary The development of more selective immunosuppressive agents to mitigate transplant rejection and autoimmune diseases requires effective strategies of blocking signaling pathways in T cells. Current immunosuppressive strategies use cyclosporin A (CsA) or FK506 to inhibit calcineurin, which dep
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High-Throughput Synthetic Platform for Natural Product Analog Libraries

Summary Background: In small molecule drug development, researchers typically develop biased libraries in which all members share a particular characteristic, such as an ability to interact with a particular target ligand or structural features designed to mimic a particular aspect of a class of nat
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Synthesis of Compounds with Peptide Characteristics

Summary Although peptides have shown some promise in clinical trials as therapeutic agents, its success has largely been limited by several factors, including rapid degradation by peptidases, poor cell permeability, and a lack of binding specificity resulting from conformational inflexibility. Over
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Purification of a Smooth Muscle Cell Mitogen from Beta Tumor Cell Conditioned Me

Summary This invention describes a novel human growth factor, sometimes referred to as "BTC-GF". BTC-GF is a mitogen for smooth muscle cells, 3T3 fibroblasts, and retinal pigment epithelial cells, but has no such effect on endothelial cells. Applications -smooth muscle replication in hypertension
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A microfluidic differential manometer for cellular-scale hydrodynamics

Summary Background: The development and application of microfluidic systems have increased dramatically in recent years. The systems that typically involve controlled fluid flow through a number of microfluidic channels can provide unique platforms useful in both research and production. Flow thr
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"'Armored"' Bubbles and Droplets

Summary Background: Colloidal particles absorbed on liquid interfaces have long been reported to stabilize emulsions and foams. Recently, individual droplets densely covered with small particles have been proposed as a possible means of obtaining a variety of composite particles and hollow locked
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Generation of Monodisperse Particles using Microfluidics: Control over Size, Shape and Composition

Summary The invention constitutes microfluidic methods of forming particles that are substantially monodisperse. The technology builds on the technology disclosed in Harvard Case: 2215 – "Method and Apparatus for Fluid Dispersion", which creates monodisperse fluid droplets in a microfluidic flow f
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A Microconcentrator and Microfilter for Suspensions such as Blood

Summary Background: In healthcare, chemical analysis, environmental testing and other fields it is useful to separate particulate substances that are suspended in a fluid. For example separating cells from body fluids. So far, these techniques have typically required substantial capital equipment
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Next Generation Pulmonary Malarial Vaccine

Summary Scientists encounter difficult obstacles in attempting to develop vaccines against malaria. For example, malaria parasites of the same species but isolated from different geographic locations may be genetically and immunologically distinct, so vaccines that protect against one geographic iso
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Keratinocytes Derived from Human Embryonic Stem Cells

Summary The investigator has discovered a method for isolating and propogating keratinocytes from human embryonic stem (ES) cells. Production of an isolated keratinocyte culture proceeded step-wise from ES cell implantation in scid mice, followed by colony fragmentation of the embryoid body, circumf
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Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")

Summary Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrices (see Harvard Case No. 1438). The present invention extends the polony technology to provided minia
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Multiplexing long DNA syntheses

Summary The invention enables multiplex gene synthesis in a single reaction, using very low concentrations of oligonucleotides. The method, which employs a unique temporary tagging strategy, offers significant advantages in terms of speed and economy over existing methods for building genes, and eve
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Method and Apparatus for Forming Multiple Emulsions

Summary Everyday emulsions have drops of one liquid dispersed in an immiscible continuous liquid. A multiple emulsion has immiscible droplets dispersed in drops dispersed in an immiscible continuous liquid (double emulsion). The IP describes a simple apparatus that can make multiple emulsions with a
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Electrostatic Steering of Charged Droplets in Microfluidic Devices

Summary The invention consists of means of charging droplets and then using that charge to choose which channel a droplet will enter at a bifurcation. There is a need to have fast, accurate means of precisely sorting and directing materials in an automated way on a microfluidic device. Examples o
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Method and Apparatus for Fluid Dispersion

Summary The invention is a microfluidic device for focusing and/or breaking fluid sections and drops. The subject fluid flows in the device's central channel as the dispersing fluid flows in the two outer channels. The outer fluid exerts pressure and viscous stresses that focus the inner fluid into
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Electric Field Mediated Emulsification in a Flow Focusing Microfluidic Device

Summary This invention describes a microfluidic electro-flow focusing device. The essence of the device is the application of an electric field at a flow focusing junction between two immiscible fluids. The electric field creates charged drops and large forces necessary for emulsification, while the
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MicroArray Spot LINEar Regression (MASLINER) software

Summary Signal intensities between samples on a microarrary typically vary by as much as three to four orders of magnitude, frustrating efforts at comparative analysis of samples assayed in parallel. At any given laser power or photomultiplier tube gain (PMTG), some signals will be below detection t
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Microscale Electromagnetic Device

Summary This invention concerns devices and methodology to control the positioning and movement of magnetic and non-magnetic nanoparticles in a fluid with nanometer precision. The devices allow for the independent and simultaneous control of many particles. The devices utilize a grid of current carr
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Method of Creating Self-Assembled, Selectively-Permeable Colloidosome Structures

Summary Colloidosomes are spherical shells of micron-sized particles made by the simple technique of self-assembly onto emulsion droplets. These hollow, elastic capsules are ideal for efficiently encapsulating active agents for selective and timed release because they are highly controllable in stre
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Surface-Bound Double-Stranded DNA Protein Arrays

Summary Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions between proteins and nucleic acid molecules. Intermolecular analyses enabled by this technology are advan
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Rational Design of Anxiolytic and Anticonvulsant Drugs

The balance between neuronal excitation and inhibition is critical for information processing in the brain. When this balance is disrupted, epilepsy and anxiety disorders may result. This balance depends on inhibitory neurotransmission mediated primarily through GABAA receptors. These receptors c
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Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistance and low absorption rates. This thermoplastic’s many qualities make it an exceptional candidate for
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Continuous Production of Microcellular Fibers

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final plastic. The pores are small enough that clarity of the plastic is unaffected, and because of the po
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Novel Antihemophilic (AHF) Formulations: Surface Coated Dispersion Systems as a Delivery Vehicle for AHF and its Fragments

Liposome technologies were developed to circumvent the problems associated with delivering therapeutic proteins into the human body. By encapsulating the protein of interest, the liposome allows the protein to remain in the circulation long enough t o have a pharmacological effect. While liposomes c
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Polymer Solar Cells using Self-Assembled Monolayer modified Zinc Oxide/Metal as Cathodes

Introduction Conjugated polymer-based organic solar cells are considered an essential source of inexpensive renewable energy due to their advantages of being fabricated by low-cost and large-area printing and coating techniques on light-weight flexible substrates. Bulk heterojunction (BHJ) solar cel
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Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re
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Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact strength of any thermoplastic, has a high resistance to corrosion, moisture, and abrasion, and has
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Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only millimeters in size while manipulating liquid volumes of picoliter size or less. In order to effectively
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Biomarkers for Cardiovascular Disease

Introduction Cardiovascular disease (CVD) is the leading cause of death among both men and women in the United States and, as such, is associated with high costs in terms of health care, morbidity, and mortality. An important aspect of the fight to reduce CVD is the development of diagnostic tests t
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DNA Binding Compounds for Genetic Regulation and Medical Diagnosis and Therapy

Compounds that bind to DNA could be used to target drugs to DNA and to regulate expression of genes. Indeed, many compounds have been discovered (e.g. Distamycin) which bind to the minor groove of DNA, but the bond is too weak for reliable medical application. Scientists at the University of Cal
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Method for Obtaining Oxide Catalysts on the Base of Exfoliated Layered Aluminosilicates

The subject of the offer is a novel, affordable and environmentally friendly method of synthesis of oxide catalysts with high surface area dispersed on aluminosilicate supports. The method may be applied in the production of catalysts for many processes, such as dehydrogenation and oxidation of hydr
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Method of Detecting, Characterizing, and Quantifying Bulk, Light-Element Materials Using High-Energy, Penetrating X-Rays

Introduction X-rays have long been used in the characterization of a wide variety of materials. However, conventional techniques for dealing with light-element (or low-Z) materials, such as those containing nitrogen and carbon, are too low in energy to penetrate significant distances into enclosing
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Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic Imaging

Introduction Gadolinium (Gd3+) is chelated with diethylenentriaminepentaacetyl (DTPA) to provide contrast in magnetic resonance (MR) imaging to identify pathogenic tissues. Unfortunately, the Gd3+-DTPA complexes approved for clinical use are cleared within a few minutes and do not provide sufficient
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Dual Drive Planetary Mill

There are many industrial fields today that require finely ground powder. The production of sub-micron size powder is receiving increased attention because of the increasing demand for structural ceramics, magnetic materials, electronic packing materials and metal-ceramic composites. At present, suc
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Novel Adsorbent Systems for Water Purification Using Metal Oxide Bound to Substrate and Heated Metal Oxide Particles

Introduction There is an ever increasing need for potable water. Improvements in conventional purification technologies allow for savings in both time and money and ensure that clean water is available in areas that need it. Technology Description Professor Benjamin at the University of Washington h
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Inductive Salinometer with Data Logging Capabilities and Toroidal Sensor

Introduction Salinity levels in seawater are not constant and can vary dramatically both temporally and spatially due to phenomena such as temperature, precipitation, deep-water upwelling, and tidal action. These variations are especially pronounced in coastal and estuarine waters where seawater int
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Redesigned third leg

Introduction Ladder injuries are among the most common injuries among orchard workers in Washington state. Ladders tipping over, sliding of the third leg, worker falling off the ladder, and worker missing the last rung were the most common sources of injuries. Due to the resistance in the industry t
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Safe last step

Introduction A common cause of injury among orchard workers in Washington state occurs when the user dismounts the ladder. The user often cannot accurately gauge the last step of the ladder because the line of sight is obscured by the apple bag when descending the ladder, with their back facing the
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Smart Ladder

Introduction A leading cause of worker injury in the fruit tree industry involves orchard ladder stability and the level of awareness of the user when climbing and dismounting the ladder. Due to cultural and economic reasons, industry acceptance of all-new designs has been low. Rather than radically
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A Retrofit Automobile Head Restraint for Whiplash Injury Prevention

Introduction Head restraints were introduced in US vehicles in 1969 with the aim of reducing the frequency and severity of neck injury in rear-end motor vehicle collisions. However, whiplash injuries of the cervical spine still continue to be the single most expensive medical claim to insurers. The
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Enhancing Occupant Protection in Side Impact Automobile Crashes

Introduction Pelvic fractures account for about 12% of injuries suffered in side impact motor vehicle accidents. The direct mechanism of the crash and resulting injury involves the door of the vehicle on the impacted side being punched into the occupant's pelvis and thorax. Pelvic fracture and rib d
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New GFT NMR Experiments for Complete Resonance Assignment of Proteins

This invention describes a set of new GFT NMR experiments for the assignment of backbone and side-chain resonances of proteins. The invention applies a Gaussian Matrix to the data acquisition and processing methods, creating the ability to adjust th e investments of NMR sampling time to the actual d
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Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic Imaging

Introduction Gadolinium (Gd3+) is chelated with diethylenentriaminepentaacetyl (DTPA) to provide contrast in magnetic resonance (MR) imaging to identify pathogenic tissues. Unfortunately, the Gd3+-DTPA complexes approved for clinical use are cleared within a few minutes and do not provide sufficient
...

Smart Ladder

Introduction A leading cause of worker injury in the fruit tree industry involves orchard ladder stability and the level of awareness of the user when climbing and dismounting the ladder. Due to cultural and economic reasons, industry acceptance of all-new designs has been low. Rather than radically
...

Safe last step

Introduction A common cause of injury among orchard workers in Washington state occurs when the user dismounts the ladder. The user often cannot accurately gauge the last step of the ladder because the line of sight is obscured by the apple bag when descending the ladder, with their back facing the
...

Application of Grating Light Reflection Spectroscopy in Analytical Sensors

Introduction There are a number of methods for measuring bulk fluid compositions in statics and flow by visible light reflection characteristics from the optically inhomogeneous wall of a vessel. Surface Plasmon Spectroscopy (SPS) on gratings and randomly rough surfaces has proven to be especially s
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Colloid and Interface Science

Objective/function The laboratory is active in the field of investigation of colloidal systems and applications of new colloids, with a focus on formation and characterization of dispersed systems, ranging in size from nanoparticles and nanocapsules through microparticles and microcapsules, up to
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The Center for Process Development

Objective/function The Center for Process Development of the Hebrew University of Jerusalem is the leading independent contract R&D facility of its kind in Israel. Its areas of activities are process development, scale-up, and custom synthesis specifically focused to the pharmaceutical, fine chem
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Surface Chemistry, Colloids and Emulsions Laboratory

Objective/function The laboratory is active in the fields of synthetic organic chemistry of surfactants; physical chemistry; surface and colloid science - emulsion technology, crystallization phenomena, extraction processes; nutraceuticals; drug delivery vehicles - nanosized self-assembled liquid
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Electro-chromic Effects for Window Glasses

Highlights Application for both building and automotive glass Sol-gel method provides simplified application procedure Optimum conditions for the electro-chromic device operation were established Darkens within seconds, blanches within 1-2 minutes No deterioration of the glass’ optical properties
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Industrially Rugged Ultrasonic Sensing, Signal Analysis and Control System

This technology describes an industrially rugged ultrasonic sensing, signal analysis, and control system. It contains two ultrasonic pulser/receiver channels connected to high speed analog to digital converters that are controlled by a digital signal processor. Two additional high speed analog to di
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Evanescent Wave Coupling Sensor for Shear/Pressure Measurement

Introduction Lower limb complications associated with diabetes include the development of plantar ulcers that can lead to infection and subsequent amputation. Several authors have postulated that shear stress is an important component of ulcer development. While it is known from force plate analyses
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End-Specific Antibody to Detect Apoptosis

BACKGROUND: Programmed cell death or apoptosis is a critical event in normal cellular differentiation and development as well as in degenerative diseases, cancer and aging. Currently, the most widely used assay for detecting apoptosis is DNA fragmentation. However, since DNA fragmentation can occu
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Method to Diagnose Giant Cell Arteritis

BACKGROUND: Giant cell arteritis is an inflammatory disease that primarily affects arteries in the head and neck. In the U.S. alone, it is estimated that 200 per 100,000 people over the age of 50 develop giant cell arteritis. If not diagnosed and treated immediately, this disease can rapidly cause b
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A New Method to Enhance Nerve Growth

BACKGROUND: Stroke and CNS injuries together cost Americans an estimated $75 billion a year in medical and rehabilitation expenses and lost productivity. Currently, there are no effective, clinically approved methods that promote nerve regeneration and subsequent restoration of CNS function. New r
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Production of Palladium Nanostructures with Shape Selection by Adding Bromide

Introduction Single-crystal, one-dimensional nanostructures of palladium are attractive as interconnects for fabricating nanoscale electronic devices. Polycrystalline, mesoscopic wires made of palladium have been utilized for resistance-based detection of hydrogen gas. However, polycrystalline wires
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Respiratory Detection System (RDS)

Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventional techniques have significant drawbacks: for instance, electrochemical techniques have low sensiti
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Method of Detecting, Characterizing, and Quantifying Bulk, Light-Element Materials Using High-Energy, Penetrating X-Rays

Introduction X-rays have long been used in the characterization of a wide variety of materials. However, conventional techniques for dealing with light-element (or low-Z) materials, such as those containing nitrogen and carbon, are too low in energy to penetrate significant distances into enclosing
...

Inductive Salinometer with Data Logging Capabilities and Toroidal Sensor

Introduction Salinity levels in seawater are not constant and can vary dramatically both temporally and spatially due to phenomena such as temperature, precipitation, deep-water upwelling, and tidal action. These variations are especially pronounced in coastal and estuarine waters where seawater int
...

Design of Spring Actuators Based on Ferromagnetic Shape Memory Alloys and Composites

Introduction Shape memory alloys (SMA) and ferromagnetic shape memory alloys (FSMA) have shown tremendous promise for a wide variety of applications because of their ability to “remember” a previous state when either heat or a magnetic field is applied, respectively. This is especially important fo
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Lycopene/phospholipids Powders Preparation

The present invention is based on a novel method for encapsulating in liposomes substantially water immiscible carotenoids. Therefore, there are provided by the present invention formulations comprising liposomes loaded with an amount of at least one water immiscible carotenoid, pharmaceutical compo
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Improved Cache Performance with Reduced Energy

Highlights Cache design improves performance by ~10% Win-win situation: design that improves performance also reduces power consumption Consists of a main cache structure preceded by a small, highly associative filter Blocks inserted into the cache are far more likely to be frequently reused, re
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Compiler Aided Ticket Scheduling (cats)

Highlights Today’s personal computers (PCs) are rapidly becoming heterogeneous multi-core computing environments with PC cards having their own CPUs. Few applications really take advantage of all the available processing power. Currently there is no generic programming model and corresponding run
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System and Method for Providing Multi-sensor Super-resolution

A super-resolution enhanced image generating system is described for generating a super-resolution-enhanced image from an image of a scene, identified as image g.sub.0, comprising a base image and at least one other image g.sub.i, the-system comprising an initial super-resolution enhanced image gene
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New View Synthesis from Plural Images Using a Trifocal Sensor Data Structure in a Multi-view Parallax Geometry

The invention is embodied in a process for synthesizing a new image representing a new viewpoint of a scene from at least two existing images of the scene taken from different respective viewspoints. The process begins by choosing a planar surface visible in the at least two of the existing images a
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Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only millimeters in size while manipulating liquid volumes of picoliter size or less. In order to effectively
...

A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analys
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Computerized Medical Record for Labor, Delivery, Postpartum, & Nursery

This invention, nicknamed OB.exe, comprises a computerized medical record and a database system that actively manages information on normal laboring women and term newborns. The database captures 800 data elements representing more than 90% of the patient�s clinical data (excluding fetal monitoring
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Steroid-saponins from Fenugreek Seeds

Highlights Fenugreek seed extract, containing steroid saponins, is a natural foaming agent. Reduces the interfacial surface tension between two immiscible liquids, stabilizes emulsions of oil in water and foams Outperformed other known emulsifying agents in stabilising oil-in-water emulsions Surf
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Catalysts for the Production of Small Molecules

Highlights Method for the general synthesis of robust C(sp3)-metalated transition metal complexes as catalysts for transfer hydrogenation of ketones Catalysts enable hydrogen-free hydrogenation Efficient catalysts for the production of small molecule building blocks for the chemical industry Our
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Synthetic Spider Silk

Highlights Spider silk is about three times as strong and twice as elastic as silkworm silk but spider behaviour precludes its production by spiders in captivity. Dragline silk, the strongest spider silk, is one of seven types produced by orb-weaving spiders, is 25 times as tough as high-tensile
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Smart Ladder

Introduction A leading cause of worker injury in the fruit tree industry involves orchard ladder stability and the level of awareness of the user when climbing and dismounting the ladder. Due to cultural and economic reasons, industry acceptance of all-new designs has been low. Rather than radically
...

Design of Active Materials and Structures based on Composites of Shape Memory Alloy and Shape Memory Polymer

Introduction Shape memory alloys (SMA) and shape memory polymers (SMP) have shown tremendous promise for a wide variety of applications because of their ability to “remember” a previous state when heated. However, they can only remember a single shape. The ability to remember two shapes would make t
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Plants Transformed with a Potato Virus Y Gene

Plants transformed with a potato virus Y gene Abstract The invention relates to chimeric plasmids comprising at least one non-sttural potyvirus gene or fragment thereof, which gene is capable of being expressed in a plant transformed with the chimeric plasmid, the thus transformed plant being
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New Fungi to Control Plant Mites and Powdery Mildew

Highlights Naturally occurring, unmodified fungi as biological pesticides No associated health or environmental problems Trials demonstrate control of citrus mites and grape powdery mildew, resulting in better quality and yields Environment-friendly alternative to chemical pesticides Our Innovati
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Genetically Controlled Carotenoid Production

Highlights Carotenoid-associated proteins (CHRC and CHRD) were isolated from cucumber flowers From these, new genes, promoters and their nucleotide sequences were derived that can be used to produce, accumulate, and sequester high levels of carotenoids in cells. Enables the production of large qu
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Sustained-release Treatment System for Oral Disorders in Pets

Highlights Novel system for coating animals’ teeth with long-lasting varnish capable of sustained delivery of therapeutic ingredients Overcomes problems of compliance with veterinary medications for oral diseases Development of the system in very advanced stage and advanced clinical trials Our In
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Drought-tolerant Trees

Highlights Molecular breeding, routine in agriculture, has not been widely applied to forest-trees, leaving a need for biotechnology solutions to create superior genotypes and direct introduction of specific traits via genetic engineering. Methods for efficient identification of molecular and met
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A Method for Generating Plant Variability

Highlights Method enhances the generation of a spectrum of new variants in a specific plant Creates a high rate of variability that allows subsequent selection of phenotypes with improved traits, e.g., increased resistance to disease or environmental factors or for biofuel production When tested
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Iodine Veterinary and Agricultural Applications

Highlights Iodine is a powerful bactericide and fungicide and is active against viruses. Iodine and iodine complex preparations are widely used as disinfectants in veterinary medicine, particularly in the post-milking disinfection of udders. These new preparations are more potent antiseptics than
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Viability of Microorganisms Entrapped in Dried Cellular Hydrocolloid Carriers Under Ultraviolet Radiation

Highlights There is a need for a method to protect live biological control agents that have been deposited on the ground or sprayed on plants against UV radiation Viable micro organisms are entrapped in dried solid hydrocolloid carriers The hydrocolloid beads are porous, allowing release of produ
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Outer Membrane Protein B1 of Moraxella Catarrhalis

The present invention includes a method for the isolation and purification of outer membrane protein B1 as well as B1 peptides from Moraxella catarrhalis, and the resulting compositions. The method involves growing the bacteria in iron-depleted medi um to enhance the expression of the B1 protein, ha
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Inhibition of Obesity-induced Lipotoxicity

Highlights Nutritional supplement reduces cellular damage caused by exposure to high levels of fat Lipotoxicity inhibition in obese people effective without requiring weight loss Proof of effectiveness was demonstrated using a combination of three antioxidant compounds, already approved for human
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Novel emulsifier for food industry without organic solvents and detergents

Highlights Phospholipids influence the interfacial surface tension between water and oil so can be used by the food industry for emulsifying, dispersing, instantising and similar tasks Phospholipids can be substituted for egg yolk as emulsifier in “all natural” products – lower cost, do not cause
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Temperature-stable Liquid Droplets

Highlights Capsules with liquid-containing core suited to variety of purposes encapsulate liquids such as coffee, wine, or juice within droplet core for taste sensations include pharmaceutical ingredients for use as medication Membrane withstands heat treatment in pasteurization, also withstands
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