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Microscopy Control System and Method

A method for controlling laser scanning microscopy of a probe comprising at least one cell is disclosed. The method comprises the steps of acquiring at least one initial image of the probe and identifying at least one cell within an initial probe image. Using a pre-defined grammar, a first set of sc
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Viral Encoded Pellino Protein and Its Uses

This invention relates to a pharmaceutical composition. In particular, it relates to a virally encoded form of a Pellino protein and its use in the regulation of signalling pathways that are associated with immune disorders.
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Monitoring Target Endogenous Species

An electrode comprising a conducting substrate for detecting species such as nitric oxide (NO), carbon monoxide (CO), oxygen (O2) and hydrogen (H2) and a polymer matrix formed from a first layer only or first and second layers with the second layer applied to the first. The matrix forms a permselect
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Method for Detecting Phosphopantetheinyl Transferase Activity

The invention provides a method for detecting 4 -phosphopantetheinyl transferase (4 PPTase) activity, the method comprising the steps of: (a) immobilising a carrier protein domain or a functional fragment thereof on a solid support suitable for this purpose; (b) reacting the immobilised carrier prot
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Non-auxotrophic Selection Marker

A non-auxotrophic selection marker located in a gene cluster encoding a metabolite for an organism, such as a fungus, lacking said marker is provided. The selection marker gene can be used to detect and confirm the introduction of foreign genes without the use of exogenous drug-resistant genes to fa
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Nitrogen Heterocycle Derivatives As Proteasome Modulators

The instant invention relates to the use of at least one nitrogen heterocycle derivative of formula (I): as proteasome activity modulator in the manufacture of a pharmaceutical composition intended to prevent and/or treat a disease condition mediated by the proteasome activity.
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Tyrosine Kinase Receptor Tyro3 As a Therapeutic Target in the Treatment of Cancer

The present invention concerns new methods for treating cancer by using TYRO3 inhibitors and methods for identifying new molecules of interest for treating cancer.
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Device for Generating Clock Signals for Asymmetric Comparison of Phase Errors

The invention relates to a device for generating clock signals, comprising a phase locked loop (100) including: - a controlled oscillator (101) capable of outputting a clock signal, - a plurality of phase comparators (102.1-102.4) capable of comparing a clock signal output by the controlled oscillat
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Nanoscale Cubic Boron Nitride

The invention relates to a method of manufacturing nanoscale cubic boron nitride and to the nanoscale cubic boron nitride thus obtained. The method according to the invention of manufacturing nanoscale boron nitride of cubic structure is characterized in that it comprises the following steps: a) com
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Method for Optimizing Blood Cell Transplants

The invention relates to the use of allogenic T lymphocytes for the preparation of a composition intended to be injected into a recipient patient as conditioning for a hematopoietic stem cell transplant, said allogenic T lymphocytes expressing a molecule enabling the specific destruction thereof.
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A Stimulatable Asymmetrical Polymersome

The invention relates to a polymer vesicle with an asymmetrical unilamellar membrane, said membrane being constituted by two distinct layers, a layer (A) and a layer (B), said layers comprising respective amphiphilic block copolymers with layer (A) comprising, in contrast to said layer (B), an effec
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Programmable Gate Array, Switch Box and Logic Unit for Such an Array

A switch box (2) for a programmable gate array including input ports grouping a plurality of inputs (I, I') and output ports grouping a plurality of outputs (O, O'), with the inputs and the outputs being connected to a downstream connection tree structure from the inputs toward the outputs and inclu
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Treatment of Mood and Anxiety Disorders

The invention relates to a selective inhibitor of EIk-1 or MSK-1 activation for use in the prevention and/or treatment of mood and anxiety disorders.
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Nucleic Acid Molecules and Methods for Exchanging Exon(s) By Transsplicing

The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messen
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Dipyrannylidene Derivatives As an Anode Interfacial Layer in Electronic Devices

The present invention relates to substrates coated with films including compounds having the following generic formula (I): formula (I) as well as the manufacturing method thereof and the use of same as an anode interfacial layer in electronic devices. The present invention also relates to organic l
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Device for Measuring the Activity of the Spinal Cord of a Vertebra

The invention relates to a device for measuring the activity of the spinal cord of a vertebra, characterized in that the device comprises at least one main probe (1) shaped so as to be attached to a spinous process (2) of a vertebra (3) and to maintain in position, on either side of the vertebra, at
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Compounds for Preventing and Treating Plasmodium Infections

The present invention relates to the use of at least one compound of formula (I) for the manufacture of a medicament intended for preventing or treating infections by a Plasmodium parasite in an individual, by inhibiting the pre-erythrocytic development stage of said Plasmodium parasite.
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Leptin Antagonists

The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequence are substituted with different amino acid residues such that the site becomes less hydrophobic, a
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Method for Detecting a Circularized DNAa, and Use of Said Method for Detecting Mutations

The present invention relates to a method for detecting a circularized single-stranded DNA by means of the isothermal hyperbranched rolling circle amplification technique, in which the primers used comprise a detectable barcode sequence and, optionally, a spacer which blocks polymerization by DNA po
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Hybrid Material, and Method for the Production Thereof

The invention relates to a material in the form of a cellular solid monolith consisting of an inorganic oxide polymer. Said monolith comprises macropores which have an average size dA of 4 [mu]m to 50 [mu]m, mesopores that have an average size dE of 20 to 30 AA, and micropores which have an average
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Flying Device with Flapping Wings

The invention relates to a flying device with flapping wings, the device comprising a chassis on which two pivots are pivotally mounted about two parallel articulation axes (X), each of the pivots bearing a wing, the device comprising a first oscillation generator in order to oscillate the pivots so
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Device for Reconstructing Speech By Ultrasonically Probing the Vocal Apparatus

The invention relates to a portable device for speech recognition and/or reconstruction by ultrasonically probing the vocal apparatus, wherein the device comprises at least one ultrasonic transducer (20) for generating an ultrasonic wave and receiving a wave reflected by the vocal apparatus of the u
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Adjustable Catheter Or Endoscope Structure

The structure e.g. catheter (27), has a resiliently deformable longitudinal body (28) including a memory shaped actuator e.g. yarn (38), integrated longitudinal to the body that is in the form of an elongated cross-sectional blade. A heating unit longitudinally contracts the actuator by Joule effect
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Method and Device for Reading an Emulsion

The present invention relates to a method for reading an emulsion (3) comprising drops and a continuous phase surrounding the drops, wherein said method comprises: two-dimensional scanning of the emulsion (3), and construction of a two-dimensional image of the emulsion (3) on the basis of said scann
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Method for Longitudinally Stabilizing an Optical Cavity

The invention relates to a method for stabilizing, along the distance (L) between two mirrors (3, 4), an optical cavity (2), wherein said method comprises the steps of: injecting, into the cavity, an incident light beam in the form of a frequency comb; observing the spectrum of the light transmitted
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Spectrograph with an Elliptical Mirror

The invention relates to a spectrograph comprising a means (3) for focussing radiation emitted by a sample illuminated by a source of radiation, and a means (4) for diffracting the focussed radiation, in which, according to the invention, the diffraction means includes a flat diffraction network wit
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High-frequency Receiver with Multiple-channel Digital Processing

In the receive subsystem, the analogue-digital converter (40) works on the output of the low-noise amplifier (33), at a chosen rate (F), which corresponds to a bandwidth sampling. The processing stages comprise a custom circuit (5), with * an input memory (510) arranged to contain N successive digit
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Device for Quickly Generating a Torque on an Extended Dynamic Range with Low Inertia

The invention relates to a device for generating a torque on an output member (3) in response to a torque setpoint, comprising: a first driving member comprising at least one motor (1) with a first power, or small motor, with a shaft (2) onto which the output member is connected; a second driving me
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Analogs of Temporin-sha, and Uses Thereof

The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions including said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said n
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Peptides Modulating the Activity of IGF-1 and the Applications of Said Peptides

The invention relates to peptides that can modulate the activity of IGF-1, to a pharmaceutical composition containing said peptides, and to the applications thereof as medicaments and agents for the in vitro modulation of cellular proliferation.
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Surgical Instrument

The invention relates to a surgical instrument (1) comprising: an elongated arm (11; 307) according to a longitudinal axis and having a distal end (2; 305) mounted with a pivot joint on the elongated arm according to an axis substantially orthogonal to the longitudinal axis; a drive shaft (3) substa
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Tumour-cell-fixing Cells

The present invention relates to an isolated cell capable of fixing tumour cells, expressing the CD10 protein and expressing at least one MDR protein, and to the use of this cell for screening for anti-tumour compounds. Figure: none.
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4S-iota-carrageenan Sulfatase and Use Thereof to Obtain Alpha-carrageenan

The present invention relates to 4S-iota-carrageenan sulfatase and to the use thereof for partially or totally converting the iota-carrageenan into iota-/alpha-carrageenan or alpha-carrageenan. The invention also relates to the method for extracting said enzyme from a Pseudoalteromonas bacteria popu
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Geolocation of a Mobile Station of a Wireless Telephony Network

The invention relates to a method for locating a mobile station inside an area covered by a wireless telephony cellular network in which the mobile station operates. The method comprises using the mobile station to measure the received power (PLX) on at least seven different communication channels o
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Method for Changing the Direction of Magnetization in Ferromagnetic Layer

The invention relates to a method for changing the direction of magnetization in a top layer (2) including a ferromagnetic material, characterized in that: a) the top layer (2) is placed over a bottom layer (3) that is not magnetically coupled to the top layer (2), the bottom layer (3) including a m
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Method for Determining the Susceptibility of a Cell Strain to Drugs

The present invention relates to a method for determining the susceptibility of a cell strain to a compound intended for controlling the growth of said cell strain, comprising: - growing the cell strain in a first compound-free culture medium and in at least a second culture medium comprising the co
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Use of Interfering RNA for Treating an HIV Infection

The present invention relates to interfering RNA, in particular miRNAs capable of specifically blocking the replication of an HIV virus strain resistant to an antiretroviral compound, and to the use thereof for treating infections by said type of virus.
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Method and System for Deploying At Least One Virtual Network on the Fly and on Demand

The invention relates to a method for generating, on the fly and on demand, at least one virtual network (402, 404, 406), adapted for a specific use, on a physical network (200), referred to as an infrastructure network, including physical nodes (204, 206, 208, 210), each of said physical nodes (204
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Method and System for the Efficient and Automated Management of Virtual Networks

The invention relates to a method for the automated management of the performance of at least one virtual network (214, 216, 218) consisting of a plurality of virtual nodes installed on physical nodes (202, 204, 206, 208) selected from among a set of physical nodes forming an infrastructure network
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Method for Synthesizing Polyesters in an Acidic Ionic Liquid Medium

The present invention relates to a method for synthesizing polyesters or copolyesters having a mean molar mass, in mass MW, greater than 10000, by means of a direct polyesterification reaction between a diacid, diester, hydroxyacid, or hydroxyester and a diol, or between hydroxyacids or hydroxyester
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Amphiphilic Block Copolymer and Method for Preparing Same

The invention relates to an amphiphilic block copolymer, to the preparation thereof, and to the use thereof in the form of a self-stabilizing latex. The copolymer has the formula R5O-[-CH2CH2-O-]n-C(=O)-CR3R4-[CH2CR6R7]m-S-C(=S)-S-R1 where: R1 is a straight or branched alkyl group, an alkenyl group
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Method of Identifying Micro-organisms and their Species in Blood Culture

The invention relates to a method of identifying micro-organisms and their species in a blood culture by mass-spectrometry and to a device for implementing such a method.
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Treatment of Tumours Using T Lymphocyte Preparations

The invention relates to the treatment of a tumour in a patient, by injecting T lymphocytes depleted of regulatory T lymphocytes, and expressing a molecule enabling the specific destruction thereof, wherein the patient receives, beforehand, a non-myeloablative or myeloablative lymphopenia-inducing t
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Thermoreversibly Crosslinked Elastic Bituminous Composition

The invention relates to a bituminous composition comprising at least one bitumen and at least one organogelling molecule taken alone or as a mixture, said organogelling molecule being represented by the following general formula (I): where: A represents an acyclic, cyclic or polycyclic, saturated o
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Methods and Systems for Expanding AC133+ Cells and Directing Differentiation

The invention provides, among other things, methods and systems for expanding CDl 33+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and
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Use of Centrifugal Partition Chromatography for Purifying Galanthamine

The invention concerns the use of centrifugal partition chromatography in displacement mode for implementing a process for purifying galanthamine or its derivatives, from a starting composition, containing at least 20% of galanthamine or its derivatives. Said method comprises a step of centrifuging
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C4d/C4b Standard for Quantitative Flow Cytometry of Humoral Transplant Rejection

The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d complement bound to a carrier consisting of erythrocytes or microparticles. The invention also conc
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Bacteria Having Protecting Activity Against Botrytis Cinerea

The invention relates to bacteria having protecting activity against Botrytis cinerea: said bacteria are selected from the strains Acinetobacter, Bacillus, Pantoea and Pseudomonas. Application in the biological control of Botrytis cinerea.
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Method and Device for Taking Shots Using a Plurality of Optoelectronic Sensors

The method of the invention can be used for taking shots using a plurality of optoelectronic sensors (Oi to O'i) in order to create a final sequence of combined images that can be displayed on screens adapted to this image combination. It comprises the physical or virtual distribution of the optoele
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Device and Method for Monitoring the Vibratory State of a Rotating Machine

The present invention relates to a device for monitoring the vibrations generated by a bearing of a machine formed by two coaxial races, an outer race and an inner race, with one fixed with respect to the frame of a machine and the other rotating, between which races is trapped at least one rolling
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Communication Device and Method

The present invention relates to a communication and interoperability device with at least one electronic peripheral apparatus (2), wherein the device includes a electronic processing circuit (6) connected to at least one connection interface (5) for at least one peripheral apparatus, characterised
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Therapeutic Peptides and Method

A polypeptide comprising one or more sequences derived from CDR2 or CDR3 of a TREM-1 protein, characterised by the ability to treat, ameliorate, or lessen the symptoms of sepsis, septic shock or sepsis-like conditions.
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Casein-Derived Peptides having Anxiolytic Activity

The invention relates to peptides and, in particular, heptapeptides derived from milk casein [alpha]s1 and having anxiolytic activity. The invention also relates to pharmaceutical and food compositions containing said peptides and to the preparation methods thereof.
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Peptide useful as an antimicrobial agent has a defined sequence of 14 amino acids

Antimicrobial peptide (I) has a defined sequence of 14 amino acids. Peptide (I) with antimicrobial activity has the amino acid sequence Lys Lys Lys Lys Pro Leu Phe Gly Leu Phe Phe Gly Leu Phe. INDEPENDENT CLAIMS are also included for: (1) polypeptide (II) comprising the above sequence; (2) polynucle
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Sensor for Non-contact Electric and Magnetic Field Measurements

The present invention relates to a probe and a sensor for measuring electric fields, more specifically to a probe that in combination with an electrometer allows measurement of an electric field with high sensitivity, large bandwidth and low frequencies without making electrical contact. Thereto the
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A novel waste water purification method and a process for use therefor

This invention relates to the needs of life and namely to the purification and treatment of waste waters. This invention specifically relates to a method for treating effluents having a high concentration of organic substances which comprises using an anaerobic biological reactor with fixed cells an
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Method and System for Processing a High-resolution Image

The invention relates to a method for processing a high-resolution image (HRI) including: - a step (E30) of decimating said high-resolution image into wavelets to obtain an lower-resolution image; - a step of creating a binary mask making it possible to locate at least one object in the lower-resolu
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Generation of a Pseudorandom Data Sequence

The invention relates to a generator (1) of a pseudorandom data sequence (3) comprising searching means (5) for searching at least one search pattern (7) in an initial data sequence (9) of N bits.
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New Intermetallic Compounds, their Use and a Process for Preparing the Same

The present invention relates to new intermetallic compounds having a crystalline structure of Ni3Sn2 type for the magnetic refrigeration, their use and a process for preparing the same. The present invention further relates to new magnetocaloric compositions for the magnetic refrigeration and their
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Mutated Hyperthermophilic Phosphotriesterases and Uses Thereof

A subject of the present invention is mutated hyperthermophilic phosphotriesterases (PTEs) possessing a lactonase activity, and their uses as bioscavengers within the context of the decontamination of the surfaces of materials, of the skin or mucous membranes, contaminated with organophosphorus comp
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Natural Fiber and Resin Composite Material

The invention relates to a natural composite including a non-woven fabric reinforcement made of natural fibers and a natural matrix selected from among mixtures of tannins and lignin pre-reacted with a low molecular-weight aldehyde, the resin being between 20 and 50 wt % of the total weight of the c
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Stambomycin and Derivatives, their Production and their Use As Drugs

The present invention relates to Stambomycin compounds, their derivatives and their pharmaceutically acceptable salt thereof.
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Intermetallic Compounds, their Use and a Process for Preparing the Same

The present invention relates to new intermetallic compounds having a crystalline structure of Ni3Sn2 type for the magnetic refrigeration, their use and a process for preparing the same. The present invention further relates to new magnetocaloric compositions for the magnetic refrigeration and their
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Cellular Differentiation Process and Its Use for Blood Vessel Build-up

The present invention relates to the use of specific oxygen concentrations for implementing a process of differenti-ation of stem, provided that said stem cells are not humanembryonic stemcells, and seeded on a support, in an appropriate culture medium, wherein said differentiation leads to: -either
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ANXIOLYTIC COMPOSITION CONTAINING ALPHAs-CASEIN -DERIVED PEPTIDES

The invention relates to pharmaceutical compositions and food products containing peptides derived from the as1-casein in milk and having benzodiazepine-type activity and particularly, anxiolytic activity.
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Novel Compounds, Use Thereof As Medicaments, and Method for the Preparation Thereof

The invention relates to novel compounds having the following formula (I) in which: n is an integer from 1 to 12, in particular from 1 to 8, m and m' are, independently of one another, integers from 0 to 8, - q and q' are, independently of one another, integers from 0 to 2, p and p' are, independent
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Method for making biochips

A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method.
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Nanometric Emitter/receiver Guides

The invention relates to a nanoprobe comprising a silica fiber (2) with an end opening having a diameter of less than 100 nm, and a metallic sheath (11). The total diameter of the silica part and the metallic sheath (11) is less than 300 nm. The invention also relates to a method for producing one s
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Macroporous and Highly Resorbable Apatitic Calcium-phosphate Cement

The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting fro
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Injectable Calcium-phosphate Cement Releasing a Bone Resorption Inhibitor

The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
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Method of generating digital test objects

The method involves defining a three dimensional scene in a continuous three dimensional space. The three dimensional scene is discretized by volume elements i.e. voxel, using a balancing mechanism i.e. binary mechanism. The discretized three dimensional scene is segmented by creating two dimensiona
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Modified phosphocalcic compound, injectable composition containing same

A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth
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Piperidine derivatives, process for their preparation and pharmaceutical compositions containing them

Phenyl-carbamic acid piperidin-3-yl ester compounds (I) and their enantiomers, and addition salts with an acid or a base are new. Phenyl-carbamic acid piperidin-3-yl ester compounds of formula (I) and their enantiomers, and addition salts with an acid or a base are new. R 1> : H or methyl group; and
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Novel Melanoma Antigen Peptide and Uses Thereof

The present invention relates to novel melanoma antigen peptides and specific T lymphocytes directed to said peptides and the use thereof for treating melanoma.
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Biological Protection Device Against the Electromagnetic Waves Emitted By a Mobile Telephone

The present invention concerns the field of individual biological protection devices against emissions of electromagnetic pollution, more particularly a biological protection device against the electromagnetic waves emitted by a mobile telephone. The device includes a frame (3) and a screen (4) made
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Radiation Detectors and Autoradiographic Imaging Devices Comprising Such Detectors

The invention relates to a radiation detector through which flows a gas mixture of rare gas and carbon dioxide and which comprises an amplifying structure (7) including an input electrode (8) and an output grid (9) separated from one another by at least 500 [mu]m.
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Thin-layer Photobioreactor with High Volume Productivity

The invention relates to a photobioreactor (1) for the culture of cells, comprising a runoff substrate (2) having a surface inclined at an average slope along a direction of inclination (I-I) on which a solution flows and including an upstream side (21) and a downstream side (22), said solution comp
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Energy Conditioner

Electrical circuitry comprising a load (3) able to be powered by an electricity network (2), said electrical circuitry comprising an energy conditioner (1) positioned between said electricity network (2) and said load (3), characterized in that said conditioner (1) comprises a first converter (6), c
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Method for Synthesizing Hydroxy-bisphosphonic Acid Derivatives

The present invention relates to a method for preparing a hydroxy-bisphosphonic acid derivative or a salt thereof, from the corresponding carboxylic acid, comprising the following steps: - activation of the carboxylic acid function in the form of the boronate derivative thereof through the action of
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Hydroxy-bisphosphonic Acid Derivatives As Vector for Targeting Bone Tissue

The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: - n and m denote, independently of one another, an integer ranging from 1 to 4, - X denotes an oxygen atom or an N-R3 group, - R1 and R3 denote, independently of one another, a lin
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Method for the Silanisation of Polysaccharides

The invention relates to a method for the silanisation of polysaccharides in a homogenous medium and in the presence of ionic liquids.
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Gallium-doped Phosphocalcic Compounds

The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7, wherein 0 < x < 1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and t
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Method of Preparing Surface Chemical Gradients

The present invention relates to a method of functionalizing a substrate, comprising the bringing into contact of at least a part of the surface of said substrate, comprising aldehyde functions, with a solution comprising at least two compounds bearing an amine function and having different pKas, in
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Method of Preparing an Adduct

A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, said molecular structure(s) each comprising one nucleotide chain onto which is hybridized at least one PNA-encoded molecule.
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Calcium/sodium Salt of Inositol Tripyrophosphate As an Allosteric Effector of Hemoglobin

The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amo
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Methods and Compositions for Treating Cancer

The present invention relates to uses or methods for treating proliferative diseases, in particular cancer, implementing ruthenium compounds, as well as to compositions containing same.
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Method of Reducing Multi-drug Resistance Using Inositol Tripyrophosphate

Inositol trisphosphate (ITPP) causes normalization of tumor vasculature and is a particularly effective cancer therapy when a second chemotherapeutic agent is administered following partial vascularization. ITPP also treats, alone or in combination, multi-drug resistant cancers. ITPP can also be use
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Oral Galenic Form, Polymer Production Method and Use of Same

The polymers according to the invention comprise a polysaccharide block (17) and several hydrophobic polyacrylic blocks (18) enabling the polymer to remain intact until it reaches the colon. The polysaccharide block is degraded by the colonic microflora irrespective of the pH, while the polyacrylic
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Synthesis of Resorcylic Acid Lactones Useful As Therapeutic Agents.

Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and
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Irreversible Inhibitors Useful for the Treatment of Kinase-related Pathologies

The present invention provides new compounds (I) having a kinase inhibitory activity and useful for treating cancer.
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Apparatus and Processes for Generating Variable Concentration of Solutes in Microdroplets

The present invention relates to systems and methods for generating microdroplets with varying concentrations of a particular solute from a solution at fixed concentration.
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Labelled Silica-based Nanomaterial with Enhanced Properties and Uses Thereof

The present invention relates to labelled silica-based nanoparticles with enhanced properties, to process for preparing them and to uses thereof.
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Polycyclic Molecules Discriminating Neutron and Gamma Radiation

The invention relates to a novel molecule family discriminating neutron and gamma radiation and to a method for the preparation thereof. Said molecules are also useful for detecting radiation (X, gamma, electrons, protons, ions), and thus for manufacturing radar and industrial or medical dosimetry i
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Three-dimensional Foam Photocatalysts Structured with Carbon Or Carbonated Material

L'invention concerne un photocatalyseur comportant une mousse alvéolaire sélectionné parmi la mousse de carbone et la mousse d'un matériau carboné, tel qu'un polymère, et une phase photocatalytiquement active, déposée directement sur ladite mousse alvéolaire ou sur une phase intermédiaire déposée su
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Preparation of Graphene By Mechanically Thinning Graphite Materials

The invention relates to a method for producing a dispersion of graphene particles or flakes in a liquid medium L, including the following steps: (a) providing a bar or block (5) of solid graphite material M; (b) rubbing said material M against the surface S (2) of a substrate so as to create a rubb
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Monoclonal Anti-claudin 1 Antibodies for the Inhibition of Hepatitis C Virus Infection

The present invention provides monoclonal antibodies that specifically bind to the extracellular domain of human Claudin-1 on the cell surface, thereby inhibiting HCV entry into susceptible cells and preventing HCV infection of these cells; and hybridoma cell lines which produce such monoclonal anti
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Catalytic Phosphination Method

The invention relates to a double or triple catalytic phosphination method, essentially performed in a single step of injecting phosphine groups on a di-, tri- or tetra-halobiaryl compound.
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Tocopherol Derivatives with a Long Hydroxylated Chain, which Can Be Used As Neurotrophics

La présente invention a pour objet tout composé isolé ou synthétique, et en particulier les composés de formule (I), provoquant la différentiation de cellules précurseurs d'oligodendrocytes, ainsi que la modulation de l'activation de la microglie. Elle concerne également les méthodes de préparation
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Biologically Active Compositions, Methods for Producing the Same and Biological Applications

Use of a product from plants comprising extracts, fractions and/or molecules as G-protein coupled receptor (TGR5) specific agonist, having minimum effective concentration (EC50) of greater/equal to TGR5 natural ligand comprising litocholic acid, not activate the farnesoid X receptor (FXR) nuclear re
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Cyclitols and their Derivatives and their Therapeutic Applications

The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate deriva
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