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Detection of Short Rna Sequences
An assay for detection of short sequences of RNA in a synthetic or clinically isolated sample is presented herein. Particular reference is made to detecting RNA based pathogens, such as H5 influenza.
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Intein-based Fluorescent Bio-circuit for Vitamin D Detection
This invention is directed to an intein-based vitamin D fluorescent biosensor that accurately and rapidly measures la,25-hydroxyvitamin D3. Measurement at picomolar quantities is noted. Particular reference is made to the use of Escherichia coli (E. coli) as a sensor organism, although yeast and mam
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Enhanced Ultra-high Resolution Acoustic Microscope
An optical-acoustic transducer structure includes at least one metal or semiconducting film in which a part of a pump light pulse is absorbed to generate a sound pulse; and at least one dielectric film. The thicknesses and optical properties of the at least one metal or semiconducting film and the a
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Nanostructured Sorbent Materials for Capturing Environmental Mercury Vapor
The present invention is a method and material for using a sorbent material to capture and stabilize mercury. The method for using sorbent material to capture and stabilize mercury contains the following steps. First, the sorbent material is provided. The sorbent material, in one embodiment, is nano
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Long Term Potentiation with Cyclic-glur6 Analogs
This invention discloses CN2097-like compositions that facilitate the induction of long-term potentiation (LTP). In one embodiment the method comprises inducing long-term potentiation in a subject by the method of administering a therapeutically effective dose of a CN2907-like compound.
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Serum-based, Diagnostic, Biological Assay to Predict Pregnancy Disorders
The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum samples from such subjects exhibit an ability to disrupt the architecture involving fetal trophoblasts and
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Apparatus, Methods, and Computer Program Products Providing Dynamic Provable Data Possession
In one exemplary embodiment, a method includes: storing data for a file, organized as blocks, each having a portion of the file (301); and maintaining a skip list for the data (302). The skip list is an ordered tree structure having a root node, internal nodes and leaf nodes. Each leaf node correspo
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Fe3o4-m(au-like)-nanoparticles for Antibody-conserving Target-specific Platin Delivery
An antibody-conserving method for linking a therapeutic platinum compound to nanoparticles comprising Au Iike-Fe3O4, which is used for both drug delivery and tumor diagnosis.
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Method and Apparatus for Model-based Detection of Structure in Projection Data
In one aspect, a method and apparatus for determining a value for at least one parameter of a configuration of a model associated with structure of which view data has been obtained including detecting at least one feature in the view data, and determining the value for the at least one parameter of
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Method for Producing Nanostructures on a Surface of a Medical Implant
A method for treating a surface of a medical implant to create nanostructures on the surface that results in increased in-vivo chondrocyte adhesion to the surface. Further, disclosed is a method to fabricate a drug delivery system. The drug delivery system includes a medical implant that has undergo
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Method and Apparatus for Estimating Body Shape
A system and method of estimating the body shape of an individual from input data such as images or range maps. The body may appear in one or more poses captured at different times and a consistent body shape is computed for all poses. The body may appear in minimal tight-fitting clothing or in norm
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Fuel Cell, Membrane Electrode Assembly
An acid resistant composite catalyst comprising dumbbell-shaped composite nanoparticles each comprising a noble metal nanoparticle epitaxially conjugated to a ferrite particle, and/or flower-shaped composite nanoparticles each comprising a noble metal nanoparticle epitaxially conjugated to at least
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Magneto-optoelectronic switch and sensor
A Magneto-Optoelectronic Device MOD (10) includes a magnetic sensing device (12), such as a magnetoresistive device or a magnetic tunnel junction device, that is combined with a semiconductor light emitter (14), such as a LED or a laser diode, to create a compact integrated device where changes in a
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Fluorogenic Substrates for Protein Phosphatases and Assays Incorporating the Substrates
Provided is a class of fluorogenic protein phosphatase substrates. These fluorogenic substrates comprises a carbamate moiety having a carbamate functional group other than hydrogen bonded to the carbamate nitrogen, a fluorophore containing a fluorophore functional group able to covalently bond to th
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Methods for Identifying Nucleotide Ligands
Methods of identifying associations between nucleotide ligands and target molecules include amplifying a pool of non-random oligonucleotides to form libraries of oligonucleotides, contacting the library with a target molecule and separating the non-random oligonucleotides that associate with the tar
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Methods and Apparatus for Model-based Detection of Structure in View Data
In one aspect, a method and apparatus for determining a value for at least one parameter of a configuration of a model associated with structure of which view data has been obtained including detecting at least one feature in the view data, and determining the value for the at least one parameter of
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System, Method, and Apparatus for Sorting At Least Partially Dynamic Data
Embodiments of methods, apparatuses, devices and systems associated with sorting candidate values are disclosed.
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Gap Reduction Techniques for Stochastic Algorithms
In one exemplary embodiment of the invention, a method includes: receiving, by an input, input data descriptive of a stochastic scheduling optimization problem; generating, by a processor, at least one solution to the stochastic scheduling optimization problem using a one-step anticipatory algorithm
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Improved Techniques for Stochastic Combinatorial Optimization
In one exemplary embodiment, a method includes: modeling, by at least one processor, a problem as an approximated exogenous Markov decision process (X-MDP); converting, by the at least one processor, the approximated X-MDP into a Markov decision process (MDP); solving, by the at least one processor,
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Psoriatic Phenotype Mice, Cell Lines, Treatments, and Methods
A genetically-modified, non-human animal, ES cells and methods for diagnosing and identifying agents useful in the treatment of psoriasis, and psoriatic conditions or disorders is provided.
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Treatment and Prophylaxis of Epilepsy and Febrile Seizures
Provided are methods for treatment and prophylaxis of convulsive disorders and seizures, such as epilepsy and febrile seizures, by modulating TRPVl channel activation.
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Improved Apparatus and Method for Assessing Visual Learning
An improved test apparatus and method for assessing visual learning in mammals is provided. The stimuli presented to the mammal are disposed and arranged on the floor of the test apparatus instead of on the walls.
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Medical Implants, Prostheses, Prosthesis Parts, Medical Instruments, Devices and Auxiliary Contrivances Made of a Halogenide-modified Magnesium Substance
The use of a magnesium substance, whose corrosiveness is altered as a result of modification with halogenides, enables medical implants, prostheses or prosthesis parts and medical instruments, devices and auxiliary contrivances, especially surgical instruments or tools, for use in and on the human o
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Electromagnetic Microsystem for Manipulating Magnetic Micro- Or Nanopearls
The invention relates to an electromagnetic microsystem for manipulating magnetic micro- or nanopearls in a fluid. Based on this, possibilities for specific manipulation of such micro- or nanopearls are specified. For this purpose, the electromagnetic microsystem comprises at least one microelectrom
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Novel Ansamitocin Derivatives
Provided are among other things ansamitocin derivatives, pharmaceutical compositions comprising these novel ansamitocin derivatives, methods for the production of the ansamitocin derivatives and their use for the treatment of cancer.
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Means for Treating Myosin-related Diseases
This invention relates to a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin.
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Novel ansamitocin derivatives
This invention relates to the field of biologically active compounds and specifically to novel ansamitocin derivatives, pharmaceutical compositions comprising these novel ansamitocin derivatives, methods for the production of the ansamitocin derivatives of the general formula (I): and their use for
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Process and Apparatus for Ion Channel Characterization
The present invention provides a process and an apparatus for performing the process, for ion channel characterisation, especially for determination of the impact of effector compounds onto the ion channel activity. For measuring, ion channels are comprised in lipid membrane vesicles. For detection,
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Laser Device Comprising a Diffraction Grating and Coupled Laser Resonators
The present invention provides a laser device wherein one diffraction grating (1) and at least two reflectors (4, 2) are arranged such that two coupled resonators (A, B) are formed for the light path. This laser device is an arrangement forming a first optical resonator (A) comprising a first (4) an
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Method for Characterization of Objects
A method for characterization of objects has the steps of: a) describing an object with an elliptical self-adjoint eigenvalue problem in order to form an isometrically invariant model; b) determining eigenvalues of the eigenvalue problem; and c) characterizing the object by the eigenvalues.
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Method and Apparatus for Enhanced Video Coding
Standard video compression techniques apply motion-compensated prediction combined with transform coding of the prediction error. In the context of prediction with fractional-pel motion vector resolution it was shown, that aliasing components contained in an image signal are limiting the prediction
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Medical implant and method of its manufacture
The implant has an outer mantle layer consisting of a set of coils (10) movably arranged to each other in a longitudinal direction. A hollow space is provided between the coils, which exhibit conicity and differ in rotational directions. The spirals differ in its starting point and/or direction of t
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Method for Producing Phosphate-bridged Nucleoside Conjugates
The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method a nucleophile is first dissolved in a non-aqueous solvent and dried, and a cyclosaligenyl phosphate compound is subsequently added to the solution.
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Method for Braking an Internal Combustion Engine
The invention relates to a method for braking an internal combustion engine having a non-flammable fluid, wherein the non-flammable fluid is injected into the combustion chamber of the internal combustion engine, and the injection occurs around the time of the highest pressure within the combustion
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Di- und Triphosphat-Prodrugs, insbesondere Nukleosiddi- und -Triphosphat-Prodrugs
The invention relates to a propharmaceuticals useful compounds, pharmaceutical compositions produced therefrom, and drug and pharmaceutical dosage forms and a process for preparing the compounds of the invention. The invention provides bioreversible masked nucleoside diphosphates (NDP) and triphosph
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Method for the Stereoselective Synthesis of Phosphorus Compounds
The present invention relates to a method for the stereoselective synthesis of phosphorus compounds, wherein in the first reaction step a chiral auxiliary is covalently bound to the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride, the product from the first
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Bonding agent
Binder (11) comprises a particulate body (12), which forms a solid phase while contacting with a liquid medium (13), where each body is encapsulated with at least a first agent and then formation of solid phase can takes place, and the quantity of the encapsulated body (14) is so loaded that the enc
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Geothermal heat assembly
The method involves producing a forced ground water circulation at the underground (U) at a region of an earth heat exchanger (12) by blowing of gas i.e. air (L), into a well (2) provided at the underground. The air is blown near a well bottom (28) in the ground water (G) in the well, and a wellhead
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Spatial structure, especially for using galleys
The spatial structure (1) comprises a support structure with lateral, bottom and roof walls (6) for a room structure. The support structure comprises a frame (3) whose rod elements (4) are connected over a rod node point (5), such that the course of the rod element is provided for a force path of th
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Process and Apparatus for the Microbial Production of a Specific Product
The process according to the invention for the microbial production of a specific product and methane comprises the following steps: a) the production in a bioreactor (2, 10) of a specific product from a specific substrate using a specific organism, the producer, wherein during the production of thi
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Inhibitors of the Myelin-associated Glycoprotein (mag)
The invention relates to a composition having the general structure (formula), wherein R1 is a hydrophobic group, R2 is hydrogen (H), a cation or an alkyl ester, R3 is hydrogen (H) or a group that can be converted into the hydroxy group under physiological conditions, R4 is a hydrophobic group, R5 i
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System to handle samples taken under pressure has a sealed transfer mechanism into a vessel to maintain the pressure and temperature conditions of the sampling point
The system is for handling and/or study of samples gathered under pressure, to maintain the pressure conditions of the sample environment. The holder for the test object has a ball valve (3) for a fluid- and pressure-tight sealing of the sample holding zone. A coupling (6) gives a gas- and pressure-
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Flame Ionization Detector
The flame ionization detector, which has a feed and an ignition device (7) for the fuel gas, a feed for the sample gas, a combustion chamber (4) in which the sample gas is ionized by the flame, and electrodes (8, 1) to which a voltage is applied in order to generate and measure the ion current, is d
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Electromagnetic field distribution determining robot system for gigahertz transverse electromagnetic cell, has sensor suspended at flexible clamping elements that are connected with drive for specifyi
The system has a positioning device with a drive for positioning a sensor. The sensor is suspended at two flexible clamping elements e.g. wire. The clamping elements are connected with the drive in a region of ends of the drive for specifying effective element length, where the ends turn towards the
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Lightweight wood-based board and process for producing it
The invention relates to a process for producing a sandwich board, comprising the following steps: providing an upper covering layer, providing a lower covering layer, providing an intermediate layer arranged between the upper and lower covering layers, compressing the upper and lower covering layer
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Method for the Determination of Intra- and Intermolecular Interactions in Aqueous Solution
The present invention relates to the determination of intra- or intermolecular interaction between molecules in aqueous solution, said method comprising the steps of: (a) determining the dehydration ([Delta]Gdehydration) of all atoms in the intermolecular interface, (b) adding the vacuum hydrogen bo
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Surface-modified structures, useful e.g. in optical or catalytic applications, comprise substrate, e.g. of glass, silicate primary coating and secondary coating, e.g. of metal
A novel surface-modified structure (I) comprises (a) a substrate, (b) a silicate primary coating and (c) a secondary coating and/or particles containing element(s) other than silica and oxygen. The chemical composition of (b) differs from that of (a) and (c). Either (b) is located between (a) and (c
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Hollow waveguide used in medicine and in structural analysis comprises a channel structure having an inner coating with a specified thickness
Hollow waveguide comprises a channel structure having an inner coating with a thickness of less than 50 nm. An independent claim is also included for a method for the production of the hollow waveguide.
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Multilevel laser medium has layer that is made of laser material, which is excited to stimulate emission on laser wavelength, and has another layer that is made of absorber material that works to abso
The multilevel laser medium has a layer (3) that is made of a laser material, which is excited to stimulate emission on a laser wavelength, and has another layer (1) that is made of an absorber material that works to absorb the same wavelength. The two layers are optically coupled together directly
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Systems and Methods of Blood-based Therapies Having a Microfluidic Membraneless Exchange Device
The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. I
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Piscine Reovirus Immunogenic Compositions
The invention is directed to immunogenic compositions and methods for inducing an immune response against Piscine reoviruses in an animal. In another aspect, the invention relates to antibodies that bind Piscine reovirus poplypeptides. In yet another aspect, the invention relates to methods for prev
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Bioreactor, Devices, Systems and Methods
Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation
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Agents for preventing and treating disorders involving modulation of the RyR receptors
The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds
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Novel Anti-arrythmic and Heart Failure Drugs That Target the Leak in the Ryanodine Receptor (ryr2)
The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for using these novel compounds to limit or prevent a decrease in the level of RyR2-bound FKBP12.6 in a su
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Novel anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
The present invention provides methods for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject. The present invention further provides methods for treating and preventing atrial and ventricular cardiac arrhythmias, heart failure, and exercise-induced sudden cardiac dea
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Human Notch3 Based Fusion Proteins As Decoy Inhibitors of Notch3 Signaling
This invention provides a fusion protein comprising a signal peptide, EGF repeats 1-X of the extracellular domain of human Notch3 receptor protein wherein X is any integer from 12 to 34, and an Fc portion of an antibody bound thereto. This invention also provides a method for treating a subject havi
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Nucleic acids for inhibiting hairless protein expression and methods of use thereof
The present invention provides DNAzymes and ribozymes that specifically leave Hairless Protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of Hairless Protein mRNA. The invention also provides various methods of inhibiting the expression
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Device, Apparatus and Method for Providing Photostimulation and Imaging of Structures
According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds
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Ngal-binding Siderophores and Use Thereof to Treat Iron Deficiency and Iron Overload
The invention provides compositions comprising a lipocalin, such as NGAL, and a mammalian siderophore that are useful as iron chelators and iron donors. The invention also provides mammalian siderophore compounds of Formula (I): The invention further provides, methods of treatment and methods of dia
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Histone Acetyltransferase Activators and Uses Thereof
The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or
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Methods for predicting pregnancy outcome in a subject by HCG assay
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular iso
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Method for assaying protein-protein interaction
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein, a cleavage site for a proteol
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Rage Fusion Proteins and Methods of Use
Disclosed are RAGE fusion proteins comprising RAGE polypeptide of soluble human sRAGE fragment with the certain amino acid sequence and non-RAGE polypeptide linked thereto. Said protein is used for treatment of diabetes and complications connected with diabetes.
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Methods, Devices, and Systems for On-demand Ultrasound-triggered Drug Delivery
Injectable or implantable drug delivery systems providing on-demand ultrasound- triggered drug release and methods for controlling the release of drug in a patient are provided herein. The on-demand drug delivery systems contain a drug depot and a drug encapsulated in an encapsulating material, wher
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Systems and Methods for Non-Periodic Pulse Sequential Lateral Solidification
The disclosed systems and method for non-periodic pulse sequential lateral solidification relate to processing a thin film. The method for processing a thin film, while advancing a thin film in a selected direction, includes irradiating a first region of the thin film with a first laser pulse and a
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Methods for fabricating nanoscale electrodes and uses thereof
The present invention relates to methods for fabricating nanoscale electrodes separated by a nanogap, wherein the gap size may be controlled with high precision using a self-aligning aluminum oxide mask, such that the gap width depends upon the thickness of the aluminum oxide mask. The invention als
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Asynchronous Digital Circuits Including Arbitration and Routing Primitives for Asynchronous and Mixed-timing Networks
Asynchronous digital circuits are described, including arbitration and routing primitives for asynchronous and mixed-timing networks. An asynchronous arbitration primitive has two data inputs and one data output. A mutual exclusion element is used to select the first-arriving data request from one o
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Compensating for Atrioventricular Block Using a Nucleic Acid Encoding a Sodium Channel Or Gap Junction Protein
A method of increasing the velocity of AV conduction in a mammal that may be in heart block or at risk of heart block by causing, in an AV node and/or His bundle having less than normal conduction speed, the expression of a sodium channel or gap junction protein, such as the SkM-I channel, Cx43 or C
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Hierarchical Assembly of Nanostructured Organic Heterojunctions for Photovoltaic Devices
Systems and methods for hierarchical assembly of nanostructured organic heterojunctions for photovoltaic devices are described. Particularly, an apparatus for converting light energy to electrical energy is provided. An apparatus includes one or more organic photovoltaic devices. Photovoltaic device
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Confocal Double Crystal Monochromator
A monochromator is adapted to select at least one band of wavelengths from diverging incident radiation. The apparatus includes a first crystal and a second crystal. A band of emitted wavelengths of the first crystal is adapted to the at least one band of wavelengths. A surface curvature of the firs
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Spectral and Temporal Laser Fluorescence Analysis Such As for Natural Aquatic Environments
An Advanced Laser Fluorometer (ALF) can combine spectrally and temporally resolved measurements of laser-stimulated emission (LSE) for characterization of dissolved and particulate matter, including fluorescence constituents, in liquids. Spectral deconvolution (SDC) analysis of LSE spectral measurem
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System and Method for Dynamically and Interactively Searching Media Data
The disclosed subject matter is directed to systems and methods for searching a database of media content wherein the user can dynamically and interactively perform searches and navigate search results. One or more search anchors are received, and at least one of the search anchors is associated wit
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Peristaltic Pump Devices, Methods, and Systems
A peristaltic pump with a removable pump race module has guiding channels for receiving at least a portion of a flexible fluid-carrying tubing and an adjusting device for displacing a flexible inner portion of the removable pump race module to change the compression on the fluid-carrying tubing. The
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Devices and Methods for Providing Stimulated Raman Lasing
Devices and methods for providing stimulated Raman lasing are provided. In some embodiments, devices include a photonic crystal that includes a layer of silicon having a lattice of holes and a linear defect that forms a waveguide configured to receive pump light and output Stokes light through Raman
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Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/melanoma
This invention provides an isolated nucleic acid molecule which encodes immunoglobulin receptor, Immunoglobulin superfamily Receptor Translocation Associated, IRTA, protein. Provided too, are the IRTA proteins encoded by the isolated nucleic acid molecules, IRTA1, IRTA2, IRTA3, IRTA4 or IRTA5 protei
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Anti-drug Vaccines
The present invention relates to anti-drug vaccines based on conjugates between the drug and a non-immunogenic carrier protein. In preferred embodiments, it provides for anti-cocaine vaccines and their use to diminish the effects and/or use of cocaine in a subject.
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Control of Spore Germination
Provided is a method of stimulating germination of a spore of a Gram-positive bacterium. Also provided is a method of inhibiting germination of a spore of a Gram-positive bacterium. Additionally provided is a composition comprising (i) a preparation of cell walls from a Gram-positive bacterium or (i
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Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under conditions that permit the expression of the gene so as to thereby reverse the cancerous phenotype of
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Turkey Viral Hepatitis Virus and Uses Thereof
The invention is directed to a isolated a Turkey Viral Hepatitis picornavirus-like viruses associated with Turkey viral hepatitis, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to antibodies against antigens from Turkey Viral Hepatitis picornavirus-like vi
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Dental Diagnostic and Dental Restoration Methods, Systems, Apparatuses, and Devices
Devices, methods, and systems for the design, fabrication, modification, and implantation of dental prostheses. An implant is created that has a shape closely or precisely conforming to the natural shape of a modified or unmodified tooth socket. The implant is used to anchor any of a variety of dent
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Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) in brain and uses thereof
The present invention provides for a transgenic non-human animal whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter; and (b) a DNA sequence which encodes a receptor for advanced glycation endproducts (RAGE), wherein the promoter and the DNA sequence which encodes the
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Cancer Stem Cells, Kits, and Methods
The present invention provides a cancer stem cell that has, inter alia, the properties of asymmetrical cell division, tumor initiating capacity, and metastatic competence. This cancer stem cell population is phenotypically characterized by the lack of major histocompatibility antigens and differenti
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Delivery of Dna or Rna Via Gap Junctions from Host Cells to Target Cells and a Cell-Based Delivery System for Antisense or siRna
A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap ju
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Systems, Methods, and Devices for Microbubbles
A suspension of gas-filled microbubbles can be synthesized by sonicating a lipid solution and a first gas in a reaction volume. The resulting microbubble suspension can be stored for later use, for example, for infusion into a patient for gas delivery thereto. Various techniques can improve the shel
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Rage Regulates Rock Activity in Cardiovascular Disease
A method is provided for treating a RAGE-related disorder in a subject afflicted therewith comprising administering to the subject a therapeutically effective amount of an antagonist of rho-associated protein kinase 1 (ROCK1) so as to thereby treat the RAGE-related disorder. A method is also provide
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Universal Methylation Profiling Methods
This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransf erase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. This invention also provides neo
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Use of Urinary Ngal to Diagnose Sepsis in Very Low Birth Weight Infants
Methods for diagnosis of sepsis very low birth weight (VLBW) infants are disclosed. The diagnostic methods for sepsis are based on determining whether a bodily fluid sample, such as a urine sample, contains an amount of neutrophil gelatinase-associated lipocalin (NGAL) protein that exceeds or is les
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Compounds and Methods for Inhibiting Serotonin Synthesis
Compounds having the structures below that are TPH1 inhibitors are provided: The compounds are useful for lowering serum serotonin levels in a patient in need thereof, e.g., to increase bone mass. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease s
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Fluid Separation Devices, Systems and Methods
A membraneless separation device can be applied to a variety of treatments, such as the ultrafiltration of blood for a patient with end stage renal disease. An ultrafiltration device can include a membraneless separation device, which separates an incoming blood flow into a substantially cytoplasmic
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Substrate Laser Oxide Removal Process Followed By Electro Or Immersion Plating
Method of ablating the surface of a substrate including providing a dry substrate and an electrolyte source, ablating the surface of the dry substrate to at least partially remove a native oxide layer, and immersing the ablated dry substrate in the electrolyte source, in which the dry substrate is a
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Methods, Apparatus and Systems for Magnetics Stimulation
A coil suitable for tissue stimulation and especially for transcranial magnetic stimulation (TMS) may be used in conjunction with a pulse generator to induce electric field in the brain with less attenuation in depth compared to existing TMS coils. In an example, a coil winding is formed in a soleno
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Ligand Binding Site of Rage and Uses Thereof
The present method provides for an isolated peptide having an amino acid sequence corresponding to the amino acid sequence of a V-domain of a receptor for advanced glycation end product (RAGE). The present invention also provides for an isolated peptide having an amino acid sequence A-Q-N-I-T-A-R-I-
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Compounds and Methods for Treating and Preventing Exercise-induced Cardiac Arrhythmias
The present invention provides a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject, a method for treating or preventing exercise-induced cardiac arrhythmia in a subject, and a method for preventing exerciseinduced sudden cardiac death in a subject. Also pr
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Methods and Compositions for Treating T-cell Leukemia
The present invention relates to compositions and methods that may be used to diagnose and treat cancer, particularly T-cell leukemia. According to one preferred embodiment of the present invention, methods are provided for determining whether reducing or blocking NOTCH-1 activation will be effectiv
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Inhibiting Staphylococcus Epidermidis Infections
The invention relates to Staphylococcus epidermidis peptides, antibodies and nucleic acids that can inhibit Staphylococcus epidermidis infection of a mammalian subject and colonization of a medical device in the mammal.
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Systems and Methods for Displaying Three-dimensional Images
Systems and methods for displaying three-dimensional (3D) images are described. In particular, the systems can include a display block made from a transparent material with optical elements three-dimensionally disposed therein. Each optical element becomes luminous when illuminated by a light ray. T
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Apparatus and Methods for Processing Compression Encoded Signals
Apparatus and methods for processing compression encoded signals are provided. In some embodiments, a signal processing method is provided that includes receiving a subband of a compression encoded signal at a subband processor, generating envelope information regarding the subband of the compressio
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Systems and Methods for Wirelessly Receiving Data
In accordance with some embodiments,, receivers for receiving a wireless data transmission are provided, the receivers comprising at least one amplifier that receives an RF input signal and produces at least one amplified signal; a mixer that mixes the at least one signal to produce a mixed signal;
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Systems, Methods, and Media for Identifying Matching Audio
System, methods, and media that: receive a first piece of audio content; identify a first plurality of atoms that describe at least a portion of the first piece of audio content using a Matching Pursuit algorithm; form a first group of atoms from at least a portion of the first plurality of atoms, t
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Systems, Devices, and Methods for Continuous-time Digital Signal Processing and Signal Representation
Systems, devices, and methods for continuous-time digital signal processing and signal representation are disclosed. This includes a continuous-time analog-to-digital converter that is configured to receive an analog signal and convert it to a continuous-time digital signal without using a clock or
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