PATENTS
For Sale or License
Notify me of New Entries
Receive an email whenever a new patent is added.
You can unsubscribe at any time.
Solid State Device
A system that incorporates teachings of the present disclosure may include, for example, a solid-state selector having a vessel for carrying a liquid medium with one or more molecules surrounded by ions, a solid state conductive structure doped with impurities having one or more through-holes extend
...
Electrically Small Antenna Devices, Systems, Apparatus, and Methods
The utilization of small antennas for mobile devices and for low frequency (long wavelength) applications is desired. Further, efficient use of transmission power is desirable, especially in mobile applications. For this purpose, a system is provided that includes one or more of: a multiple-resonato
...
A Drawing Process for the Continuous Fabrication of Nanofibers Made of a Variety of Materials
Direct-write techniques are provided for the high speed (up to millimeter per second) and continuous fabrication of elongated nanostructures such as nanofibers. The nanofibers may be of an ionic solid, a hydrated salt, a molecular solid, or aggregated colloidal particles such as semiconductor partic
...
Interwoven Wire Mesh Microcavity Plasma Arrays
Embodiments of the invention provide for large arrays of microcavity plasma devices that can be made inexpensively, and can produce large area but thin displays or lighting sources Interwoven metal wire mesh, such as interwoven A1 mesh, consists of two sets of wires which are interwoven in such a wa
...
Process for Continuous Solvent Production
A continuous process for production of solvents, particularly acetone-butanol-ethanol (ABE) using fermentation of solventogenic microorganisms and gas stripping is provided. The solventogenic microorganisms are inoculated in a nutrient medium containing assimilable carbohydrates (substrate) and opti
...
Co-doped Titanium Oxide Foam and Water Disinfection Device
A quaternary oxide foam, comprises an open-cell foam containing (a) a dopant metal, (b) a dopant nonmetal, (c) titanium, and (d) oxygen. The foam has the advantages of a high surface area and a low back pressure during dynamic flow applications. The inactivation of Escherichia coli (E. coli) was dem
...
Imaging of Anatomical Structures
A system that incorporates teachings of the present disclosure may include, for example, an imaging device having a Magnetic Resonance Image (MRI) scanner to generate MRI data associated with soft tissue of a patient, and supply said MRI data to diagnostic equipment that selects one or more normativ
...
Minimally-invasive Measurement of Esophageal Inflammation
The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embo
...
Anticoagulant Antagonist and Hemophilia Procoagulant
A method for treating a coagulation deficient patient comprises administering an amount of polyP to the patient sufficient to reduce the PT Test value or Dilute PT Test value of the plasma of the patient.
...
Anti-Antiogenic Fragments of Pigment Epithelium-Derived Factor (PEDF)
The present invention provides anti-angiogenic derived from pigment epithelium-derived factor (PEDF) pharmaceutical compositions comprising the peptides, and methods of preventing angiogenesis. Such methods are useful in treating angiogenesis-associated disorders and diseases.
...
Altered Intracellular Localization of BRK/Sik Protein Tyrosine Kinase in Human Prostate Tumors
The invention provides methods for detecting abnormal prostate conditions, such as benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), and adenocarcinoma, in an animal by comparing the amount of the Breast Tumor Kinase (BRK) tyrosine kinase in the nuclei of prostate lumina
...
Methods, Compositions and Articles of Manufacture for Contributing to the Treatment of Cancers
Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic
...
System and Method for Ultrasonic Image Processing
A system that incorporates teachings of the present disclosure may include, for example, an ultrasonic (US) imaging system having a transducer, and a controller managing operations of the transducer. The controller can be operative to cause the transducer to transmit a coded ultrasound signal to an
...
Recognition Via High-dimensional Data Classification
A method is disclosed for recognition of high-dimensional data in the presence of occlusion, including: receiving a target data that includes an occlusion and is of an unknown class, wherein the target data includes a known object; sampling a plurality of training data files comprising a plurality o
...
Large Format High Resolution Interactive Display
An interactive display device of a preferred embodiment includes a display surface and a touch interface associated with the display surface. A first LCD layer generates a dynamic parallax barrier and a second LCD layer generates stereoscopic images in cooperation with the first LCD layer. A light s
...
Self-Healing Laminate System
A laminate material may include a first flexible layer, and a self-healing composite layer in contact with the first flexible layer. The composite layer includes an elastomer matrix, a plurality of first capsules including a polymerizer, and a corresponding activator for the polymerizer. The laminat
...
Label-free Biosensors Based Upon Distributed Feedback Laser
A biosensor based upon a vertically emitting, distributed feedback (DFB) laser is disclosed. In one configuration, the DFB laser comprises a replica-molded, one- or two- dimensional dielectric grating coated with a laser dye-doped polymer as the gain medium. A sensor is also described in which the g
...
Microchannel Laser Having Microplasma Gain Media
The invention provides microchannel lasers having a microplasma gain medium. Lasers of the invention can be formed in semiconductor materials, and can also be formed in polymer materials. In a microlaser of the invention, high density plasmas are produced in microchannels. The microplasma acts as a
...
Mri Involving Replacement of an Antenna By Another Antenna
A system that incorporates teachings of the present disclosure may include, for example, a Magnetic Resonance Imaging system comprising a Magnetic Resonance (MR) scanner to selectively couple to one among a plurality of antennas without compromising spatial alignment with an anatomical sample during
...
Method of Dispersion Controlled X-ray Amplification in Laser System
A method for controlling amplification of coherent tunable radiation in the x-ray region of the electromagnetic spectrum through dispersion control has a step of generating pulsed laser radiation having a selected power, pulse width, wavelength, and leading edge velocity of propagation v?. The metho
...
Electron Injection-controlled Microcavity Plasma Device and Arrays
An embodiment of the invention is a microcavity plasma device that can be controlled by a low voltage electron emitter. The microcavity plasma device includes driving electrodes disposed proximate to a microcavity and arranged to contribute to generation of plasma in the microcavity upon application
...
METHODS FOR DIAGNOSING AND TREATING SQUAMOUS CELL CARCINOMA UTILIZING miRNA-205 AND INHIBITORS THEREOF
Disclosed are diagnostic and therapeutic methods related to squamous cell carcinoma. In particular, the diagnostic methods relate to detecting miRNA-205, thereby diagnosing an aggressive form of squamous cell carcinoma. The therapeutic methods relate to inhibiting the function of miRNA-205, thereby
...
Microelectromechanical Device and System
A microelectromechanical device for electromechanical testing a specimen having a nano-scale dimension is formed on a multi- layered semiconductor substrate (chip) and includes an electrothermal or electrostatic actuator for applying a displacement load (force) to the specimen, a load sensor for sen
...
Compositions and Methods for Imaging Cells
A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety and the second reporter moiety form a signaling complex that produces a detectable signal when the firs
...
Haptic Device with Controlled Traction Forces
A haptic device includes a substrate that is subjected to lateral motion such as lateral oscillation with one or more degees of freedom together with modulation of a friction reducing oscillation in a manner that can create a shear force on the user's finger or on an object on the device.
...
Vaccine Compositions and Uses Thereof
The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems comprising an antigen and a dendritic cell-targeting peptide. Such compositions target vaccines to dendr
...
Self-assembling peptide amphiphiles and related methods for growth factor delivery
The invention provides peptides that are capable of binding growth factors, as well as peptide amphiphiles comprising certain of these peptides, micellar assemblies of such amphiphiles and related methods of use.
...
Nanomolar [beta]-lactamase inhibitors
New carboxyphenyl-glycylboronic acid transition-state analog inhibitors, representative of a class of compounds effective against class C [beta]-lactamase AmpC. The new compounds improve inhibition by over two-orders of magnitude compared to analogous glycylboronic acids, with Ki values as low as 1
...
Surface-immobilized Antimicrobial Peptoids
Immobilizable antimicrobial compounds incorporating antimicrobial and/or antifouling components, as can be adhered to various device structures and components.
...
Nanoarrays of single virus particles, methods and instrumentation for the fabrication and use thereof
A novel coordination chemistry or metal ion binding approach to controlling the site-isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography including Dip Pen Nanolithography. By using the surface chemistry that is inherent in many viruses, metal-i
...
A Direct-write Nanolithographic Method
An atomic force microscope (AFM) having a tip coated with hydrophobic compounds, which is performed as dip pen nanolithography (DPN), for transporting molecules from the atomic force microscope tip (AFM) to a gold substrate (AU) to write patterns on the gold substrate (AU).
...
"Click" Nanoparticle Conjugates
Modified nanoparticles are disclosed. More specifically, nanoparticles modified with an agent through a triazole linkage are disclosed. Also disclosed are methods of preparing modified nanoparticles and methods of using these modified nanoparticles.
...
Thermoelectric Compositions Comprising Nanoscale Inclusions in a Chalcogenide Matrix
Composites comprising a continuous matrix formed from compounds having a rock salt structure (represented by the structure "MQ") and inclusions comprising chalcogenide compounds having a rock salt structure (represented by the structure "AB") are provided. Composites having the structure MQ-ABC2, wh
...
High-Throughput Imaging of Graphene Based Sheets by Fluorescence Quenching Microscopy and Applications of Same
A method for imaging a graphene-based film. In one embodiment, the method includes the steps of providing a graphene-based film on a surface of a medium; forming a fluorescent coating over the graphene-based film to form a sample; illuminating the sample with light of a specific wavelength or wavele
...
Solid phase host compositions
A new family of silicon-based polymers has been prepared in which organic host components are bound covalently. The polymer is a polysilsesquioxane matrix comprising, for example, hosts such as cyclodextrins (CD) or calixarenes (CX).
...
Self-assembling Poly(diol Citrates)-protein Hydrogels
The present invention can be directed to poly(diol-citrate)-based copolymers, compositions thereof comprising protein components and methods of use and assembly.
...
Apparatus and methods for water treatment
An apparatus and method for treatment of water borne oxidized contaminants, using hydrogen as an electron donor for denitrification and reduction of other oxidized contaminants. Preliminary results reported here show that a biofilm of autotrophic denitrifiers accumulates rapidly in the wastewater se
...
Use of ECDI-fixed Cell Tolerance As a Method for Preventing Allograft Rejection
The present invention provides methods, systems, and compositions for inducing donor-specific tolerance. In particular, the present invention provides methods of administering ECDI-treated cells before, during, and/or after administration of donor transplant cells or a donor allograft in order to in
...
Zinc-activated contrast agents
The present invention relates to contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to MRI contrast agents that are activated in the presence of zinc(II) (e.g., resulting in a brighter image).
...
Polymer-graphite nanocomposites via solid-state shear pulverization
Polymer-graphite compositions and related methods of using solid-state shear pulverization as can be used to affect one or more physical properties thereof.
...
Primary Carbon Nanoparticles
The present invention provides monodisperse primary carbon nanoparticles, and methods of preparation and use thereof. In particular, the present invention provides surface-modified monodisperse primary carbon nanoparticles, and methods of preparation and use thereof.
...
Delivery of Therapeutic Agents Using Oligonucleotide-modified Nanoparticles As Carriers
Disclosed are drug delivery compositions comprising an oligonucleotide-modified nanoparticle and a therapeutic agent. Specifically, disclosed are compositions comprising a number of oligonucleotide molecules in a ratio to therapeutic agent molecules to allow a sufficient transportation of the therap
...
Methods for Total Nitrogen Removal from Waste Streams
A method and related apparatus for oxidation and reduction of a reduced aqueous nitrogen contaminant.
...
Nanostructures Suitable for Sequestering Cholesterol
Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a
...
Cyclohexane-1,3-diones for Use in the Treatment of Amyotrophic Lateral Sclerosis
The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the pro
...
Short Duplex Probes for Enhanced Target Hybridization
The present disclosure is directed to compositions and methods for detecting or associating with a target polynucleotide.
...
Compositions and Methods for Treating Lymphoma
Provided are compositions comprising PX-478, or metabolites, analogs or derivatives thereof for treatment of lymphoma.
...
Electrode Material Comprising Graphene-composite Materials in a Graphite Network
A durable electrode material suitable for use in Li ion batteries is provided. The material is comprised of a continuous network of graphite regions integrated with, and in good electrical contact with a composite comprising graphene sheets and an electrically active material, such as silicon, where
...
Methods for Scar Prevention
Provided herein are compositions and methods for preventing or reducing scar formation (e.g., hypertrophic scars). For example, provided herein are methods of administrating HMG-CoA-inhibiting agents for preventing or reducing scar formation.
...
Templated Nanoconjugates
The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.
...
Magnetic Nanostructures As Theranostic Agents
The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (
...
Method of using group III-V ferromagnetic/non-magnetic semiconductor heterojunctions and magnetodiodes
Methods of use of ferromagnetic Group III-V semiconductor/non-magnetic Group III-V semiconductor heterojunctions, with a magnetodiode device, to detect heterojunction magnetoresistance responsive to an applied magnetic field.
...
Layer by layer self-assembly of large response molecular electro-optic materials by a desilylation strategy
The preparation of robust, thin film materials with large second-order optical nonlinearities through the covalent self-assembly of chromophoric compositions and innovative use of silyl chemistry.
...
Oligonucleotide Specific Uptake of Nanoconjugates
Disclosed are nanoparticles functionalized with an oligonucleotide and a domain, wherein the domain increases cellular uptake of the nanoparticles. The domain is a sequence of nucleobases or phosphate groups, such as a poly thymidine (polyT) sequence or a phosphate polymer (C3 residue) and may be lo
...
Allelic Disorders Caused By Mutations in TRPV4
The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and heredita
...
Method for Reducing Scarring During Wound Healing Using Antisense Compounds Directed to CTGF
This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit
...
Generation of Combinatorial Patterns By Deliberate Tilting of a Polymer-pen Array
The disclosure relates to a method of forming a pattern having pattern elements with a plurality of sizes on a substrate surface with a tilted pen array that includes choosing a tilt geometry for a pen array with respect to a substrate, inducing the tilt geometry between the pen array and the substr
...
Biodegradable Nitric Oxide Generating Polymers and Related Biomedical Devices
Disclosed herein is a biodegradable nitric oxide-generating polymer comprising a nitric oxide-releasing N2O2- (NONOate) functional group. The polymer can be applied to various medical devices for the treatment of various diseases such as thrombosis and restenosis.
...
Polymer Pen Lithography
The disclosure relates to methods of printing indicia on a substrate using a tip array comprised of elastomeric, compressible polymers. The tip array can be prepared using conventional photolithographic methods and can be tailored to have any desired number and/or arrangement of tips. Numerous copie
...
Devices for Material Delivery, Electroporation, and Monitoring Electrophysiological Activity
The invention relates generally to devices for material delivery, electroporation and monitoring electrophysiological activity. In particular, the present invention provides devices and systems configured to deliver therapeutic compositions, to provide electroporation to increase therapeutic efficie
...
Force Feedback Leveling of Tip Arrays for Nanolithography
A method of leveling a polymer pen array includes contacting a pen array with a surface and measuring a total force exerted on the surface by the pen array, the pen array being disposed at a first angle with respect to a first axis of the surface and a second angle with respect to a second axis of t
...
Block Copolymer-assisted Nanolithography
In accordance with an embodiment of the disclosure, a method for forming submicron size nanostructures on a substrate surface includes contacting a substrate with a tip coated with an ink comprising a block copolymer matrix and a nanostructure precursor to form a printed feature comprising the block
...
Detection of Maternal Alcohol Exposure
The present invention provides methods, compositions, and systems for detecting in utero alcohol exposure by detecting expression level changes in certain biomarkers (e.g., in placental tissue). In certain embodiments, the biomarkers are selected from glucocorticoid receptor (GR), thyroid hormone re
...
Silicon Pen Nanolithography
Disclosed are methods of lithography using a tip array having a plurality of pens attached to a backing layer, where the tips can comprise a metal, metalloid, and/or semi-conducting material, and the backing layer can comprise an elastomeric polymer. The tip array can be used to perform a lithograph
...
Surface Independent, Surface-Modifying, Multifunctional Coatings and Applications Thereof
The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA. The treated surface is thus rendered less susceptible to fouling of the surface.
...
Nanodiamond Particle Complexes
The present invention provides various functionalized nanodiamond particles. In particular, the present invention provides soluble complexes of nanodiamond particles and therapeutic agents, for example insoluble therapeutics, anthracycline and/or tetracycline compounds, nucleic acids, proteins, etc.
...
Chiral Pyrrolidine Core Compounds En Route to Inhibitors of Nitric Oxide Synthase
Diastereomeric pyrrolidine compounds and methods of preparation, as can be used en route to the preparation of a range of nitric oxide synthase inhibitors.
...
Compositions and Methods for Treating Conditions Associated with Neuronal Dysfunction
The present invention relates to compositions and methods for the treating and empirically investigating conditions associated with neuronal dysfunction (e.g., chronic pain, epileptic neuronal activity). In particular, the present invention provides compositions and methods for using flufenamic acid
...
Live-attenuated Compositions for Bacterial Infections
The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration
...
Metastable Nanoparticle Ink Compositions and Images Made Therefrom
Self-erasing inks in which both the printing and self-erasure of color images can be controlled by the dynamic/non-equilibrium aggregation of photoresponsive surface-coated nanoparticles contained in a carrier film are provided. The aggregation is a reversible aggregation that is triggered by a phot
...
Pyrimidine-2,4,6-triones for Use in the Treatment of Amyotrophic Lateral Sclerosis
The present invention relates to the identification of inventive pyrimidine-2,4,6- triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the
...
Organic Photovoltaic Device with Interfacial Layer and Method of Fabricating Same
An organic photovoltaic device and method of forming same. In one embodiment, the organic photovoltaic device has an anode, a cathode, an active layer disposed between the anode and the cathode; and an interfacial layer disposed between the anode and the active layer, the interfacial layer comprisin
...
Multiplexed Scanometric Assay for Target Molecules
The present invention is directed to compositions and methods of use of a functionalized nanoparticle having a catalytic metal deposit.
...
Self-assembled Organic Monolayers on Graphene and Methods of Making and Using
Self-assembled organic monolayers on epitaxial graphene are described. The organic molecules are perylene derivatives including 3,4,9,10-perylene-tetracarboxylic dianhydride (PTCDA) molecules arranged in a herringbone phase and/or molecules are of the following formula: wherein R1 and R2 are alkyl g
...
Method of forming a film of graphite oxide single layers, and applications of same
A method for forming a film of graphite oxide single layers. In one embodiment, the method includes the steps of preparing a solution of graphite oxide to allow a plurality of graphite oxide single layers to be formed and dispersed in the solution; and applying the solution of graphite oxide onto an
...
Delivery of Oligonucleotide-Functionalized Nanoparticles
The present invention relates to compositions and methods for delivering an oligonucleotide-functionalized nanoparticle.
...
Matching with a Large Vulnerability Signature Ruleset for High Performance Network Defense
Systems, methods, and apparatus are provided for vulnerability signature based Network Intrusion Detection and/or Prevention which achieves high throughput comparable to that of the state-of-the-art regex-based systems while offering improved accuracy. A candidate selection algorithm efficiently mat
...
Systems, Methods, and Apparatus for Equalization Preference Learning
Systems, methods, and apparatus are provided for equalization preference learning for digital audio modification. A method for listener calibration of an audio signal includes modifying a reference sound using at least one equalization curve; playing the modified reference sound for a listener; acce
...
Compositions and Methods for Urinary Bladder Regeneration
The present invention provides compositions and methods for the regeneration of tissue. In particular, the present invention provides mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) for bladder regeneration.
...
Self-Assembly of Peptide-Amphiphile Nanofibers Under Physiological Conditions
Peptide amphiphile compounds, compositions and methods for self-assembly or nanofibrous network formation under neutral or physiological conditions.
...
Digital Image Compression By Resolution-adaptive Macroblock Coding
Disclosed is an image encoder that divides a digital image into a set of "macroblocks." If appropriate, a macroblock is "downsampled" to a lower resolution. The lower-resolution macroblock is then encoded by applying spatial (and possibly temporal) prediction. The "residual" of the macroblock is cal
...
Non-enzymatic Detection of Bacterial Genomic DNA
The present invention relates to methods for detecting for the presence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes blocking strands to inhibit target rehybridization to detect double stranded genomic DNA.
...
Antifouling Hydrogels, Coatings, and Methods of Synthesis and Use Thereof
The invention provides an antifouling hydrogel comprising an effective amount of antifouling polymer modified with a compound containing catechol functional groups to yield a modified antifouling polymer comprising at least one catechol functional end group; and an effective amount of at least one o
...
Scanning Near Field Thermoelastic Acoustic Holography (SNFTAH)
A system and method for analyzing a sample is described. The system may include, for example, a light source and a scanning probe microscope probe. The light source may generate a coherent laser beam that is modulated by a waveform of a lower frequency. The modulated laser beam is absorbed by the sa
...
Scanning Near-Field Ultrasound Holography
A high spatial resolution phase-sensitive technique employs a scanning near field ultrasound holography (SNFUH) methodology for imaging elastic as well as viscoelastic variations across a sample surface. SNFUH uses a near-field approach to measure time-resolved variations in ultrasonic oscillations
...
Click Chemistry, Molecular Transport Junctions, and Colorimetric Detection of Copper
Click chemistry is used to construct molecular transport junctions (MTJs) through assembly of a molecular wire across a nanogap formed between two electrodes. Also disclosed are methods of using click chemistry and oligonucleotide-modified nanoparticles to detect the presence of copper in a sample.
...
Separation of Carbon Nanotubes in Density Gradients
The separation of single-walled carbon nanotubes (SWNTs), by chirality and/or diameter, using centrifugation of compositions of SWNTs in and surface active components in density gradient media.
...
Methods for Nucleic Acid Transfer Into Cells
The present invention provides methods for increasing the transfer of nucleic acids into cells. In particular, the present invention provides for the use of inhibitors of HDAC6, a cytoplasmic histone deacetylase present in mammalian cells by, for example, small molecules or siRNA treatment, in incre
...
Biomarkers for Prostate Cancer
The present invention relates to compositions and methods for the detecting, treating, and empirically investigating the prostate. In particular, the present invention provides compositions and methods for using neuroligin biomarkers (e.g., NLGN-4Y) in the diagnosis, treatment, and empirical investi
...
Methylation Profile of Neuroinflammatory Demyelinating Diseases
The present invention relates to compositions and methods for diagnosing neuroinflammatory demyelinating diseases, including but not limited to, multiple sclerosis. In particular, the present invention provides methods of identifying methylation patterns in genes associated with neuroinflammatory de
...
Polyvalent Polynucleotide Nanoparticle Conjugates As Delivery Vehicles for a Chemotherapeutic Agent
The present invention is directed to compositions and methods of delivering a chemotherapeutic agent via a polynueleotide-functionalized nanoparticle (PN-NP).
...
Sorting Two-dimensional Nanomaterials By Thickness
The present teachings provide, in part, methods of separating two-dimensional nanomaterials by atomic layer thickness. In certain embodiments, the present teachings provide methods of generating graphene nanomaterials having a controlled number of atomic layer(s).
...
Intracellular Delivery of Contrast Agents with Functionalized Nanoparticles
The present invention is directed to compositions and methods for intracellular delivery of a contrast agent with a functionalized nanoparticle.
...
Localized Delivery of Nanoparticles for Therapeutic and Diagnostic Applications
The present invention is directed to compositions and methods of localized delivery of a functionalized nanoparticle.
...
Sealants for Membrane Repair
The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four-armed catechol-terminated polyethylene glycol (cPEG) and a biocompatible oxidant, hi one embodiment
...
Cardioprotective Role of Hepatic Cells and Hepatocyte Secretory Factors in Myocardial Ischemia
The present invention provides methods, compositions, and systems for treating a subject at risk for, with, or suspected of having, myocardial ischemia using hepatocyte secretory factors (e.g., AGP2, BMPER, FGF21, NRG4, and/or TFF3) or using factors that promote liver cell migration to ischemic myoc
...
Interpenetrating Biomaterial Matrices and Uses Thereof
The present invention relates to matrices (e.g., fibrin-alginate matrices; fibrin-alginate-matrigel matrices) for culture of cells, organs (e.g., ovary or fragment thereof), cells and cell aggregates (e.g., ovarian follicles, embryoid bodies), and tissues. In some embodiments, protease inhibitors e.
...
System and Method for Leveraging Human Physiological Traits to Control Microprocessor Frequency
A system and method for leveraging physiological traits to control microprocessor frequency are disclosed. In some embodiments, the system and method may optimize, for example, a particular processor-based architecture based on, for example, end user satisfaction. In some embodiments, the system and
...
Multiplexed Biomolecule Arrays Made By Polymer Pen Lithography
Methods of patterning multiple biomolecules on a surface are disclosed. The method includes inking a polymer pen array, where tips are inked with selected inks comprising the biomolecules, and transferring the biomolecules to a surface using a polymer pen lithography technique. Methods of using the
...
Novel Peptide-based Scaffolds for Cartilage Regeneration and Methods for their Use
Disclosed herein are novel peptide amphiphile molecules and compositions composed of a peptide sequence that non-covalently binds the growth factor TGF-ss1. Also disclosed are methods of using these peptide amphiphiles to create a gel scaffold in situ that enhances articular cartilage regeneration w
...
Page: 1 - <100 - <10 - 103 104 105 106 107 108 109 - 10> - 118 Next»