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Kynurenine-aminotransferase Inhibitors
Compounds of formula (I) : prodrug derivatives and/or pharmaceutically acceptable salt thereof, selectively inhibit the enzyme kynurenine aminotransferase, thereby reducing the synthesis of kynurenic acid. The compounds are used for the treatment of psychiatric and neurological diseases which benefi
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Synthesis Methods of Histone Deacetylase Inhibitors (HDACIS)
Simple and efficient procedures for the synthesis of histone deacetylase inhibitors. The procedure may provide MS-275 in 72% overall yields.
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Quantitative Real-time 4d Stress Test Analysis
Stress test analysis is facilitated through the acquired and manipulated use of a sequence of volumetric data regarding the heart (and may particularly comprise the left ventricle) for the assessment of the health state of the heart. Several provided and illustrated examples specifically relate to u
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Methods of Diagnosis and Prognosis for a Muscular Dystrophy
The invention relates to the treatment, diagnosis, and prognosis of a muscular dystrophy or myopathy. The present inventors have found that the quantity of mu-crystallin is increased in a muscular dystrophy. In particular, the inventors have found that mu-crystallin is increased in facioscapulohumer
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Arc-Sequencing Technique for Intensity Modulated Arc Therapy
The invention is directed to a radiation therapy method, and in particular, to a method of conducting an intensity modulated arc therapy (IMAT). The invention provides a planning technique that translates traditional static fixed-field IMRT plans into deliverable IMAT plans and allows IMAT to be rea
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Genetic Variants in a Hypertension Susceptibility Gene STK39 and Uses Thereof
The present invention is drawn to diagnosis and treatment of essential hypertension. In this regard, the present invention discloses genetic variants in a hypertension susceptibility gene Stk39 and its use in the diagnosis and treatment of essential hypertension.
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Compositions and Methods of Inducing Endoplasmic Reticulum Stress Reponse
The present invention provides methods of inducing cell cycle arrest and/or cell growth inhibition, with the methods comprising administering to the cells an effective dose of the compounds of the present invention.
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Metal-enhanced Fluorescence for Polarization-based Affinity Assays
A method and kit for determining the quantity of an analyte include providing a functionalized substrate and a reagent. The functionalized substrate includes metallic nanoparticles and a plurality of substantively identical bioactive target molecules affixed to a substrate. The bioactive target mole
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P53 Activator Peptides
The present invention relates to novel polypeptides that activate p53, and the polynucleotides encoding these p53 activator peptides. The present invention also relates to pharmaceutical compositions comprising the p53 activator peptides as well as methods of treating abnormal conditions, such as ma
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Compositions and Methods for the Innate Immune Response Pathway
Autoimmune diseases are the consequence of complex interactions between a mosaic of host genetic factors and etiologic elements. Celiac disease (CD) is an autoimmune disease prevalent in 1% of the general population, but is unique on two accounts; a) the majority (90%) of individuals with CD have th
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Embolectomy Stroke Device
Devices and methods for removing an obstruction from a blood vessel are described. The devices are deployed in a collapsed condition and are then expanded within the body. The devices are then manipulated to engage and remove the obstruction. A system for removing an obstruction from a blood vessel
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Aminde Detection Method and Materials
Compounds linked to a solid support through a divalent linker moiety are disclosed. In particular, compounds such as 1-hydroxybenzotriazole-6-carboxylic acid are directly linked to the support under mild conditions (i.e., in aqueous or organic solvents at neutral pH and at room temperature). The pol
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Novel Human Androgen Receptor Alternative Splice Variants As Biomarkers and Therapeutic Targets
The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to ident
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Step Trainer for Enhanced Performance Using Rhythmic Cues
A person's step length and rate may be measured, for example, through sensors that collect spatial and temporal gait parameter data. The measurements are then used to determine the rate of a rhythmic auditory cue to improve the person's gait. For example, a system links sensors to detect step rate a
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Factor VIII Compositions and Methods
The present invention provides methods of increasing the half-life and/or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and/or specific activity of factor VIII by substituting one or more amino acids in the A2 domain. It further provi
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Conjugates of 19F MR Imaging Tracers for Use in Multi-chromic MRI Imaging
Compositions for producing multi-chromic ("color") magnetic resonance images (MRI). The compositions for use as MRI imaging agents include a magnetic resonance imaging tracer having a signal emitter, such as a 19F imaging tracer (19FIT), conjugated with a magnetic signal modulator, such as a paramag
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Methods for Regulating Urinary Potassium
The internalization sequence at the C-terminal end of the ROMK protein has been identified and sequenced. It has been discovered determined that endocytosis is triggered by binding of the ROMK internalization sequence to ARH protein, which is co-localized and expressed with ROMK. New methods of trea
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Blood Coagulation Inducing Polymer Hydrogel
The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of
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Rapid Expression Cloning of Human Monoclonal Antibodies from Memory B Cells
The present application provides methods for producing human monoclonal antibodies without using hybridoma technology, antibodies produced used the described methods, and methods for using the antibodies to treat or prevent disease conditions (e.g., infection by pathogens such as the Human Immunodef
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Prognostic Tools to Predict the Efficacy of Drug Treatment Targeting Chromatin DNA Or Enzymes Acting on DNA
Disclosed are methods of predicting cell response to drug-based therapy using both PCR-Stop assays and real time PCR assays. Methods herein may be used for assessment of drug effect, evaluation of regimen suitability for a given patient, and/or for determination of an optimal drug dose. Also provide
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Immunoglobulin Constant Region Fc Receptor Binding Agents.
IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are se
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Mutual Prodrugs and Methods to Treat Cancer.
Mutual prodrugs comprising retinoids and histone deacetylase inhibitors, methods for production of the mutual prodnigs, and methods of treatment comprising administration of the mutual prodrugs. The retinoids include all-trans retinoic acid, 13-cis retinoic acid, and retinoic acid analogs that have
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Potent Inhibitory Effect of Zinc in Combination with Sulforaphane on Cancer Cell Growth
This invention relates to compositions comprising zinc and sulforaphane which can be used in the treatment or prevention of cancer. The invention also relates to methods of treating or preventing cancer, including prostate cancer, which comprises the administration of zinc and sulforaphane to a pati
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Broad Spectrum Vaccine Against Non-typhoidal Salmonella
The present invention is drawn to attenuated Salmonella serovar strains S. Typhimurium and S. Enteritidis, conjugate vaccines derived from these attenuated strains of S. Typhimurium and S. Enteritidis, comprising an O polysaccharide covalently linked to a flagellin protein, and methods for inducing
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Novel Antiproliferative Factor and Methods of Use
A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis an
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Breast cancer resistance protein (BCRP) antibodies
The Breast Cancer Resistance Protein is described, as well as the cDNA encoding said protein. This protein has been found to confer resistance to cancer chemotherapeutic drugs.
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Microcin H47 Plasmid Selection System
The present invention relates generally to stabilized expression plasmid systems. The stabilized expression plasmid systems comprise an expression vector that includes a plasmid maintenance system (PMS) and, optionally, one or both of a polynucleotide encoding a selected antigen under control of a p
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Vaccines and Immunomodulatory Therapies for Tularemia
The present invention relates to attenuated strains of Francisella tularensis from which genes in the guanine nucleotide biosynthetic pathway have been deleted and to methods for making the mutants. The invention further relates to the use of the attenuated strains to make vaccines.
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Compositions and Methods of Use of EPB1, and ErbB3 Binding Protein
Inhibition of the proliferation of hormone refractory prostate cancer cells is achieved by administering EPB1, an ErbB3 binding protein, in combination with another anti-proliferation therapy such as administration of antiandrogens, other anticancer agents, radiation therapy, or surgery. Administrat
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Inhibitors of NCCa-ATP Channels for Therapy
Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular NCca-ATP channel and
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Methods and Devices for the Detection of Biofilm
The present invention provides methods and kits for biofilm detection.
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ERG-1 Peptides and Polynucleotides and their Use in the Treatment and Diagnosis of Disease
The present invention relates to peptide and polynucleotide fragments of ERG-1, and in particular, human ERG-1a (HERG-1a) and its isoforms, and their use in the treatment and diagnosis of disease, especially cardiac diseases, such as arrhythmias, and cancer.
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Small Molecule Inhibitors of Lck SH2 Domain Binding
The present invention provides, materials and methods for modulating an immune response. The materials and methods may be used to treat diseases associated with an aberrant immune response. In some embodiments, materials and methods of the invention may be used to treat autoimmune diseases, for exam
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ZAP-70 As Predictor and Modulator of Effector Function of T Cells
In this application is described a novel, multiparameter analysis of TCR-coupled signaling and function in resting and activated naive and memory CD4 T cells, revealing a biochemical basis for immunological recall. Results reveal a novel biochemical signature imparted to memory CD4 T cells enabling
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Methods of Treating a Microbial Infection By Modulating RNase-L Expression And/or Activity
The invention relates to methods and compositions for treating a microbial infection. In the present invention, RNase-L activity has been shown to play an integral role in innate immunity and for defense against invading microbes. The present invention is drawn to exploiting the role of RNase-L in i
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Compositions and Methods Utilizing Fibrin Beta Chain Fragments of the Bbeta Chain of Fibrinogen
A composition including a peptide sequence of the formula ssX1-X2, the peptide sequence corresponding to an amino acid sequence of a fibrin beta chain fragment of a Bbeta chain of fibrinogen, wherein X1 represents an N-terminal end of the peptide sequence, and X2 represents a C-terminal end of the p
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Determination of Site of Origin for a Natural Electrical Pulse in a Living Body
Techniques include determining a first vector of temporal changes in electrical data measured at multiple electrical sensors positioned at corresponding locations on a surface of a living body due to a natural electrical pulse. A different vector of temporal changes in electrical data measured at th
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Novel Compositions and Methods for Stimulating Erythropoiesis in a Mammal
The present invention relates to compositions comprising an agent which activates herpes virus entry mediator (HVEM). The present invention also relates to compositions comprising an agonist of HVEM. The present invention also relates to methods of stimulating erythropoiesis in a mammal, comprising
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Apparatus and Method for Use in Analyzing a Patient's Bowel
An apparatus and method are provided for use in studying a patient's bowel which combines recording and analysis of physiologic parameters and patient sensory perception. A pain input detector, a pain transducer, and a processor are provided. A gas pressure transducer and flow meter may also be prov
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Aminoflavone (nsc 686288) and Combinations Thereof for Treating Breast Cancer
Disclosed are methods of treating breast cancer by administering to a mammal aminoflavone, and optionally one or more additional anti-cancer agents. According to example embodiments, the methods include methods of treating cancers resistant to endocrine therapy.
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Methods and Compositions for Facilitating Tissue Repair and Diagnosing, Preventing, and Treating Fibrosis
Compositions and methods for facilitating tissue repair by enhancing the actions of BIGH3 or at least one of its downstream effector molecules in injured tissue, and for the diagnosis, prophylactic and therapeutic treatment of fibrosis by inhibiting the actions of BIGH3 or at least one of its downst
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Methods and Compositions for the Diagnosis of Crohn's Disease
The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain em
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Biosensors
Methods for detecting a biological interaction comprising administering a substrate comprising a ligand attached to the substrate wherein the ligand binds to a receptor and wherein a signal is produced. Also disclosed is a biosensor comprising a substrate and a ligand wherein the ligand is attached
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Allylic Oxidations Catalyzed by Dirhodium Catalysts under Aqueous Conditions
The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The invention concerns the use of dirhodium (II,II) "paddlewheel complexes, and in particular, dirhodium carboximat
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Methods for the Treatment of Viral Conditions
The invention is directed to a method of stimulating PRF in a viral cell by administering an aminoglycoside antibiotic to said cell. In another embodiment, the invention is directed to a method of inhibiting viral replication by administering an aminoglycoside antibiotic to a viral cell. The inventi
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Process for Preparation of Polyolefins Via Living Coordinative Chain Transfer Polymerization
Disclosed is a method of producing a polyolefin composition comprising contacting a metallocene pre-catalyst, co-catalyst, and a stoichiometric excess of a metal alkyl; adding a first olefin monomer; and polymerizing the first monomer for a time sufficient to form the polyolefin. The method allows f
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A Novel Composition of Matter and Method for Stimulating the Growth of Beneficial Microorganisms
The invention describes a novel composition of matter obtained from the leaves of green plants, which is useful in promoting the growth of beneficial microorganisms. Specifically, that the invention describes a hydrolysate prepared from plant leaf biomass (leaf biomass hydrolysate or 'LBH') which dr
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Methods and Systems for Using Therapeutic, Diagnostic or Prophylactic Magnetic Agents
Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treat
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Probes and Methods for Detecting Analytes
Embodiments disclosed herein relate generally to probes, methods, and kits for detecting the presence of a target analyte. The probe generally comprises two strands that have regions of complementarity and do not associate with each other at the reaction temperature. In the presence of an analyte, t
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Process for Producing Lower Alkyl Alcohols from Cellulosic Biomass Using Microorganisms
At least one isolated microorganism, which converts at least 10% by weight, and preferably 50% by weight, of cellulosic biomass to a lower alkyl alcohol by direct digestion, and which produces at least 4% by volume of the lower alkyl alcohol in an aqueous-based digestion medium.
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Method for Fast Roaming in a Wireless Network
A roaming service method for a fast and secure wireless network is provided. In an embodiment of the present invention, an AP, which an STA associates with, transmits proactive keys needed for roaming to neighbor APs of the AP. When the STA moves to one of the neighbor APs, a reassociation is carrie
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Practical Method for Resource Allocation for QOS in OFDMA-based Wireless Systems
A data communication resource allocation for OFDMA based wireless systems supporting heterogeneous traffic is provided by allocating the rates to users subject to power/bandwidth constraints, according to a user selection metric and rate allocation based on traffic requirements and channel condition
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Approach to contacting nanowire arrays using nanoparticles
An in situ approach toward connecting and electrically contacting vertically aligned nanowire arrays using conductive nanoparticles is provided. The utility of the approach is demonstrated by development of a gas sensing device employing the nanowire assembly. Well-aligned, single-crystalline zinc o
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System and Method for Spatio-temporal-context Aware Interaction of Users with an Entity of Interest
A multifunctional interaction system which is capable of spatio-temporal context localization of users and of communication of audio/video streams to an entity of interest defined by the user, includes a communication domain supporting a predefined localization service, a server associated with the
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Wireless Communication Method and System for Transmission Authentication At the Physical Layer
The subject authentication scheme encompasses a large family of authentication systems which may be built over existing transmission systems. By superimposing a carefully designed secret modulation on the waveforms, authentication is added to the signal without requiring additional bandwidth. The au
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Lateral Two-terminal Nanotube Devices and Method for their Formation
An apparatus, system, and method are provided for a lateral two- terminal nanotube device configured to capture and generate energy, to store electrical energy, and to integrate these functions with power management circuitry. The lateral nanotube device can include a substrate, an anodic oxide mate
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Compressive Sensing System and Method for Bearing Estimation of Sparse Sources in the Angle Domain
Compressive Sensing (CS) is an emerging area which uses a relatively small number of non-traditional samples in the form of randomized projections to reconstruct sparse or com not pressible signals. Direction-of-arrival (DOA) estimation is performed with an array of sensors using CS. Using random pr
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High-powered Electrochemical Energy Storage Devices and Methods for their Fabrication
The present invention relates to electrochemical storage devices, such as supercapacitors, batteries, etc., and more particularly to such devices that comprise an electrochemically active coaxial nanowire. The invention particularly concerns such devices in which the coaxial nanowire comprises an in
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Low Temperature Polymer Bonding Using UV/Ozone Surface Treatment
The present invention relates to a method for bonding two surfaces to one another. The invention particularly pertains to the use of such method in which one of the surfaces is a polymeric plastic (and more preferably a polymeric thermoplastic (especially poly-(methyl methacrylate) ("PMMA") or cycli
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F-inverted Compact Antenna for Wireless Sensor Networks and Manufacturing Method
An F-inverted compact antenna for ultra-low volume Wireless Sensor Networks is developed with a volume of 0.024lambdax0.06lambdax0.076lambda, ground plane included, where lambda is a resonating frequency of the antenna. The radiation efficiency attained is 48.53% and the peak gain is -1.38 dB. The a
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High Temperature Solder Materials
A solder material is formed utilizing a transient liquid phase sintering process, where a precursor material is first formed. The precursor material comprises a plurality of metal particles including a first metal having a first melting point temperature and a second metal having a second melting po
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Thin Flexible Rechargeable Electrochemical Energy Cell and Method of Fabrication
A thin, rechargeable, flexible electrochemical energy cell includes a battery cell, or a capacitor cell, or a battery/capacitor hybrid cell that can be stackable in any number and order. The cell can be based on a powdery mixture of hydrated ruthenium oxide particles or nanoparticles with activated
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Method and Implementation for Information Exchange Using Markov Models
The replacement of secret keys is a central problem in key management. Typical solutions exchange handshaking messages, involve complex computations, or require the cooperation of trusted third parties. Disclosed herein is a key replacement method that exploits the randomness of Markov models to eff
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Method of Designing Magnetorheological Fluid Energy Absorbing Device Using Hydromechanical Analysis
A method of designing a magnetorheological (MR) fluid energy absorbing damper is provided that uses hydromechanical analysis with lumped parameters to allow a determination as to whether a potential damper design will provide predetermined characteristics, such as a desired dynamic force range and m
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Use of Hat Inhibitors and TMPRSS2 Inhibitors As Medicaments
The invention relates to the use of inhibitors of the general formula (I) where R1 is a substituent, P3 is a mono- or polysubstituted or unsubstituted, natural or unnatural a-amino acid or a-imino acid in the D configuration, P2 is a mono- or polysubstituted or unsubstituted, natural or unnatural a-
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Method for Producing Metal-containing Nanoparticles Enveloped with Polymers and Particles That Can Be Obtained Therefrom
The present invention discloses a method for producing metal-containing nanoparticles enveloped with polymers and to particles that can be obtained therefrom. In the method according to the invention, at least one anionic polymerizable monomer is polymerized at room temperature in the presence of an
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Method for Producing Photo-crosslinkable Nanoparticles in a Continuous Reactor
The present invention relates to a method for producing photo-crosslinkable polymer nanoparticles having diameters less than or equal to 100 nm and polymer nanoparticle dispersions that can be obtained therefrom. For this purpose, monovinyl compounds are radically copolymerized with divinyl compound
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Non-viral Transfection Agent
The invention relates to a non-viral transfection agent comprising polymer/nucleic acid complexes and nanofibers, wherein the polymer/nucleic acid complexes are composed of at least one nucleic acid and at least one cationic polymer. The nanofibers carry the polymer/nucleic acid complexes, wherein t
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Means for Separating Microorganisms on the Basis of Electrospun Fibers
The invention relates to composite filters for separating microorganisms from liquids that are contaminated therewith. Composite filters of the invention comprise at least one porous, liquid-permeable support material and at least one nonwoven made from electrospun fibers. The support materials are
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N-terminally Modified Tetrapeptide Derivatives Having a C-terminal Arginine Mimetic
The invention relates to multi-base, N-terminally modified tetrapeptide mimetics having a C-terminal P1 arginine mimetic, to a method for producing the same and to the use thereof in the therapy and prophylaxis of diseases that are caused by bacterial pathogens or viruses, and in the therapy and pro
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Distinguishing an Enantiomers with the Aid of Broadband Femtosecond Circular-dichroism Mass Spectrometry
The present invention provides an apparatus and a method for distinguishing enantiomers with the aid of broadband femtosecond circular-dichroism laser-ionization mass spectrometry. In this case, an fs laser system is used, the laser pulse duration (t) of which is less than or equal to 200 fs, with r
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Hydrolytically Decomposable Ionic Copolymers
The present invention provides novel hydrolytically decomposable ionic copolymers. These ionic copolymers are made up of a cyclic ketene acetal A, an anionic or cationic methacrylic acid derivative B selected from 2-methyl-methacrylate, [2-(2-methyl-1-methylen-allyloxy)-ethane sulfonate, [2-(2-methy
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Laser-based Terahertz and Millimeter Wave Source
The invention relates to a method and a device for generating electromagnetic radiation in the terahertz and millimeter range, using a non-linear medium generating the indicated radiation by differential frequency generation within the laser resonator of a suitable laser, such as a VECSEL or a disc
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Producing metal-containing nanoparticles coated with polymers, useful e.g. for producing inks, comprises preparing anionic macro-initiator solution, adding monomer, polymerizing, and adding sulfide an
Producing metal-containing nanoparticles coated with polymers, comprises: preparing a solution of an anionic macro-initiator in an aprotic organic solvent; adding at least one anionic polymerizable monomer to the above solution; anionic polymerizing the above resulting solution at room temperature;
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High performance electrospun nanofibers from polyaniline/polyamide
The invention relates to a method of producing a electrospun conductive polymer fibre by coating a non-conductive polymer fibre with conductive polymer. This can be done by a batch or a continuous process.
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Producing polymer coated metal containing nanoparticles, comprises forming anionic macroinitiators solution in solvent, adding polymerizable monomer, polymerizing, adding sulfide, metal salt and homog
Producing polymer coated metal containing nanoparticles comprises: preparing a solution of anionic macroinitiators in an aprotic organic solvent; adding at least one anionically polymerizable monomer to the solution; anionically polymerizing at room temperature; adding aliphatic or aromatic sulfide;
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Ortho-metalated, Chelate-stabilized Benzylamines of the Rare Earth Elements (RE)
The present invention describes homoleptic, ortho-metalated complexes of rare-chelatstabilisierte benzylamine. The rare earth metals are selected from Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu. In the novel complexes at least one benzylic proton of the benzylamine ligand by a
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CYCLOPENTADIENYLPHOSPHAZENE COMPLEXES (CpPN COMPLEXES) OF METALS OF THE THIRD AND FOURTH GROUP AND OF THE LANTHANOIDS
The present invention relates Cyclopentadienylphosphazen complexes (CPPN complexes) of Group III. and group IV and the lanthanides with the exception of lutetium. The novel complexes are too isolobal and isoelectronic [(CpSiN) TiR2] complexes. In the novel there is exactly one complex CPPN unit. In
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Use of an Ozone/oxygen Mixture As Primary Anticancer Therapy Through Intraperitoneal Insufflation
Squamous cell carcinomas of the ENT area (HNSCC) are a group of metastatic tumors with a high mortality rate in humans and animals. Since then discovered that the biomolecule ozone inhibits the growth of various cancer cells in vitro, we here applied the highly aggressive and lethal VX2 carcinoma HN
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Glycosylation Engineered Antibody Therapy
The instant invention is drawn to methods of generating a glycosylation- engineered antibody, and using the glycosylation-engineered antibody for treating a patient, particularly a cancer patient or a patient with an immune disease or disorder. The instant invention is also drawn to methods of gener
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Plants with Reduced Expression of Phosphatase Type 2C Gene for Enhanced Pathogen Resistance
The present invention relates to a method for down regulating an Arabidopsis protein phosphatase type 2C gene, referred to as "defense-associated protein phosphatase type 2C one" (DAPP1) that functions as a negative regulator of a plant defense pathway by contacting the gene or gene mRNA with an int
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Microwave Trigger Metal-enhanced Chemiluminescence (MT MEC) and Spatial and Temporal Control of Same
The present invention relates to a method of imaging structures and features using plasmonic emissions from metallic surfaces caused by chemiluminescence based chemical and biological reactions wherein imaging of the reactions is enhanced by the use of microwave energy and further enhanced by using
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Voltage-gated Metal-enhanced Fluorescence, Chemiluminescence Or Bioluminescence Methods and Systems
In the present invention, it is demonstrated for the first time, the influence of electrical current on the ability of surface plasmons to amplify fluorescence signatures. An applied direct current across silver island films (SiFs) of low electrical resistance perturbs the fluorescence enhancement o
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Conversion of Just-continuous Metallic Films to Large Particulate Substrates for Metal-enhanced Fluorescence
The present invention relates to a method of producing silver films having large nanoparticles caused by cracking during anaerobic annealing to provide surfaces that exhibit increased metal enhanced fluorescence. Preferably the annealing process is conducted on a silver film having a thickness from
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Radiation-resistant Mutants of a Halophilic Archaeon and Uses Thereof
The present invention relates to variants of the model halophile Halobacterium sp. NRC- 1 that have been exposed to cycles of irradiation with high doses of 18-20 MeV electrons. These novel isolated halobacterium exhibit increased resistance to radiation and may be used for bioremediation of toxic a
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Fluorescence Microscope in a Microwave Cavity
The present invention relates to an optical imaging system communicatively connected to a microwave energy producing source wherein the combination provides for increases in chemical reaction times and the ability to monitor the reactions in real time with sufficient resolution to view the location
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Method and Assay for Early Diagnosis of Prostate Cancer
A method and assay are described for determining prostate cancer and the general stage of progression of such cancer by quantifying levels of promoter methylation of gal-3, optionally in combination with the quantification of the level of GSTP1 promoter methylation, where the method and assay are no
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Biosynthetic Pathway and Genes Required for Tropodithietic Acid Biosynthesis in Silicibacter TM1040
Production and use of a sulfur-containing compound, tropodithietic acid (TDA), from the roseobacter Silicibacter sp. TM1040 is described. Specifically, a biosynthetic and regulatory pathway for TDA biosynthesis in roseobacters is described. The TDA produced from roseobacters, specifically Silicibact
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Fibrous Assemblies for Antibody Presentation, and Multiplexed Antigenic Analysis Using Same
Biofunctionalized fibers including a fiber platform and a histidine-tagged protein and, optionally, an antibody. Chitosan is a fiber useful as the fiber platform. The fiber platform may be treated with nickel or may be directly linked to the histidine-tagged protein e.g., histidine-tagged streptococ
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Improved Folding of Recombinant Proteins Via Co-expression of Archaeal Chaperones
The present invention relates to recombinant protein production, and more specifically, to methods for recovery of properly folder bioactive proteins by expressing chaperone genes from extremophilic Archaea, during recombinant protein synthesis in a host cell thereby significantly improving recovery
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Targeted Delivery of Imaging Probes for in Vivo Cellular Imaging
The present invention relates to imaging probes comprising immunoliposomes that encapsulate self-quenching concentrations of stable free radicals or high-relaxivity contrast agents, such as nitroxides or trityl radicals, wherein the immunoliposomes comprise a targeting ligand, positioned on the surf
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Recombinant Double-Stranded RNA Phage, and Use of the Same
A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restricted to, vaccine antigens, bioactive proteins, immunoregulatory prote
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Proteins Containing Expanded Polyglutamine Tracts Induce Mitochondrial Fragmentation By Disrupting Mitochondrial Fusion
Expanded polyglutamine tracts are shown to be a cause of disturbance of mitochondrial function and therefore a cause of cell toxicity and cell death and a cause of various diseases or disorders related to such effects. Such diseases and disorders may include neurodegenerative diseases or disorders,
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Methods for the Conversion of Fish Waste from Aquaculture Systems to Methane Via a Modified Uasb Reactor.
A process for treatment of sludge made up of saline organic solids or organic waste produced in a saltwater or brackish aquaculture system is described. The process includes use of a modified reactor, operating under anaerobic conditions, which yields methane from the digestion of the saline organic
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Genetically engineered co-expression DNA vaccines, construction methods and uses thereof
The present invention relates to co-expression DNA vaccines and methods for vaccinating animals against viral, bacterial and parasitic pathogens. In particular, the present invention relates to DNA vaccines that co-express antigens in combination with biologically-active components, such as adjuvant
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Ubiquilin Regulation of Presenilin Endoproteolysis, and Suppression of Polyglutamine-induced Toxicity in Cells
Use of ubiquilin is described, including utilization for reducing fragmentation of presenilin 1 and 2 and to modulate [gamma]-secretase components, Pen-2 and Nicastrin, as well as utilization for inducing increased levels of ubiquilin to reduce aggregation of polyglutamine expansion proteins known t
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Electroaddressing and In-film Bioprocessing Using Stimuli-responsive Hydrogel-forming Polymers
Methods for the generation of hydrogels formed by electrodeposition of an electroaddressable polymer are described. The hydrogels may contain one or more cell populations electroaddressed or electroaddressable to a location within the hydrogel and where the cells of the cell populations are entrappe
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Generating Electrical Power By Coupling Aerobic Microbial Photosynthesis to an Electron-harvesting System
The present invention relates to an aerobic single-chamber photosynthetic microbial fuel cell (PMFC) that does not depend on organic substrate as an energy source but instead powered only by the energy of light. Its operation is CO2-free and does not require buffers or exogenous electron transfer sh
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Engineering Broad-spectrum Disease Resistance Against Haustorium-forming Pathogens Using RPW8 As a Delivery Vehicle
The present invention relates to the increased expression of RPW8 proteins causing an increased level of the RPW8 proteins at extrahaustorial membrane with subsequent induction of pathogen inhibition reactions against haustorium forming pathogens.
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Deuterium Isobaric Tag Reagents for Quantitative Analysis
Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more 2H in each reagent. Generally, the reagents are described by the formula: reporter group - balancer group - reactive group, wherein the reporter gr
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