Microscopy Patents for Sale or License

3D Optical Microscope

An optical system is used in a microscope which is provided to observe a sample or in a light emitting device which applies a beam of light such as a laser beam onto a sample. The optical system can form an oblique path of light so that without shifting the sample or the position of the eyes of the observer can observe not only a vertical top side the sample but also a front, rear, left or right side of the sample.
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3D Optical Microscope - Optical System for Forming Optical Path of Oblique Angle and Method Thereof

An optical system is used in a microscope which is provided to observe a sample or in a light emitting device which applies a beam of light such as a laser beam onto a sample. The optical system can form an oblique path of light so that without shifting the sample or the position of the eyes of the observer (or the position of a light source of the light emitting device), the observer can observe (in the case of the light emitting device, it can apply light onto) not only a vertical top side the
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Lateral Molecular Force Microscope - Easy Access IP

Detection techniques currently used in scanning force microscopy impose limitations on the geometrical dimensions of the probes and, as a consequence, on their force sensitivity and temporal response. The University of Bristol invention is a scanning probe microscopy system based on a probe detection method that uses scattered evanescent electromagnetic waves. The patented detection system senses where the probe tip actually is in relation to the specimen and also the actual movement of the
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Method and Device for Cell Sample Diagnosis

The invention relates to a method for cell sample diagnosis on a cell sample or cell culture. In addition, the invention relates to a computer program product, a data storage medium with a computer program product stored or written thereon according to the invention, and a device for cell sample diagnosis on a cell sample or cell culture. The method according to the invention is characterized in that a) at least one extract from the cell sample or cell culture is captured by video microscopy ove
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Multi-photon Microscopy Via Air Interface Objective Lens

The present disclosure provides an optical system for depth-resolved imaging of a specimen such as living tissue in vitro (e.g., brain tissue). The optical system comprises a confocal and multi-photon microscope having an objective with adjustable glass correction and a gas between the objective lens and a specimen. The optical system also comprises an incubation chamber having a first housing with a glass aperture and a second housing enclosed by the first housing, said second housing having a
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Total internal reflection holographic microscope

The present invention provides for a digital holographic microscope using a holographic interferometer and incorporating a TIR sample mount and microscopic imaging optics. The microscope uses phase shifting from frustrated internal reflection within a prism to measure nanometric distances. The invention also provides for a numerical reconstruction algorithm of an inclined surface of the object/prism.
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Apparatus and Method for the Detection of Forces in the Sub-micronewton Range

A force microscope (1) for the detection of forces in the sub-micronewton range has a measurement head (3) which is used to carry out a relative movement with respect to a sample holder (4) and to which a carrier molecule (9) is attached on which probe molecules (10) are placed.
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Radiolabeled Monomeric and Multimeric Cyclic Oligopeptides Binding to the CXCR4 Receptor for Cancer Imaging and Treatment

A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p - L - (S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me) Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; S1 and S2 are spacer groups, which may be the same or different; L is a linker moiety containing at le
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CYCLOPENTADIENYLPHOSPHAZENE COMPLEXES (CpPN COMPLEXES) OF METALS OF THE THIRD AND FOURTH GROUP AND OF THE LANTHANOIDS

The present invention relates Cyclopentadienylphosphazen complexes (CPPN complexes) of Group III. and group IV and the lanthanides with the exception of lutetium. The novel complexes are too isolobal and isoelectronic [(CpSiN) TiR2] complexes. In the novel there is exactly one complex CPPN unit. In all, the novel complexes of cyclopentadienyl CPPN a monodentate anionic ligands of the metal atom dar.The metal atom is also bound to other anionic ligands. In a preferred embodiment, binding within C
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Means for Separating Microorganisms on the Basis of Electrospun Fibers

The invention relates to composite filters for separating microorganisms from liquids that are contaminated therewith. Composite filters of the invention comprise at least one porous, liquid-permeable support material and at least one nonwoven made from electrospun fibers. The support materials are selected from among fiber-oriented nonwovens, matted nonwovens, porous solids, tissues, paper filters, plastic filters, metal screens, and membrane filters. The electrospun fibers can be water-stable
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High-Throughput Imaging of Graphene Based Sheets by Fluorescence Quenching Microscopy and Applications of Same

A method for imaging a graphene-based film. In one embodiment, the method includes the steps of providing a graphene-based film on a surface of a medium; forming a fluorescent coating over the graphene-based film to form a sample; illuminating the sample with light of a specific wavelength or wavelengths, which is absorbed by the fluorescent coating to cause the fluorescent coating to emit light of wavelengths longer than that of the absorbed light, which is quenched by the graphene-based film s
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A Direct-write Nanolithographic Method

An atomic force microscope (AFM) having a tip coated with hydrophobic compounds, which is performed as dip pen nanolithography (DPN), for transporting molecules from the atomic force microscope tip (AFM) to a gold substrate (AU) to write patterns on the gold substrate (AU).
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Jones phase microscopy of transparent samples

Methods for displaying anisotropic properties of an object. The object is illuminated with a first test beam characterized by a first polarization that, after traversing the object, is combined with a reference beam. The combined light of the first transmitted test beam and the reference beam is analyzed by a first pair of polarization analyzers, and interference created between the first transmitted test beam and the reference beam as analyzed by the first pair of analyzers is detected to deriv
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Method and Device for the Production of a Grid with Chirp

The present invention relates to a method for the production of a grid with chirp, wherein a grid structure is inscribed in a carrier in that the carrier is exposed in a diffraction field of a diffraction grid (3), wherein the diffraction grid (3) is deformed into a state with a local and/or time-dependant relative change in length for the exposure of the carrier. The invention further relates to a corresponding device for the production of a grid with chirp.
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Enhanced Ultra-high Resolution Acoustic Microscope

An optical-acoustic transducer structure includes at least one metal or semiconducting film in which a part of a pump light pulse is absorbed to generate a sound pulse; and at least one dielectric film. The thicknesses and optical properties of the at least one metal or semiconducting film and the at least one dielectric film are selected so that a returning sound pulse results in a measurable change in the optical reflectivity and/or some other optical characteristic of the transducer structure
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Optical Fiber Microscopy Launch System and Method

A sample slide, launch system, and method for microscopy having two optical fibers positioned proximate a sample slide with optical fiber mounting elements to deliver EMR to a surface of the sample slide at a critical angle for total internal reflection microscopy. In one exemplary embodiment, the EMR from the first optical fiber and the EMR from the second optical fiber may have different polarization states and/or wavelengths.
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Systems, Compositions and Methods for Nucleic Acid Detection

The invention relates to stretch measurements of nucleic acids and correlating those measurements to the extent of double- and single-stranded content of a nucleic acid of interest, and to compositions, systems, and devices related thereto. In preferred embodiments, one performs the stretch or elasticity measurements under conditions such that one can determine a nucleic acid sequence or the presence of an oligonucleotide in a sample.
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Ultrafast Microscopy of Surface Electromagnetic Fields

System(s) and method(s) to probe electromagnetic fields at the surface of a solid-state material are provided. The technique combines ultrafast (e.g., less than 10 fs) optical excitation and electron microscopy to generate electronic excitations and image the ensuing electromagnetic fields with nanometer-scale spatial resolution and femtosecond time-scale resolution. In addition, time-of-flight energy analysis facilitates imaging of relaxation a generated electronic excitation. The dynamics of t
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Nanoscale optical microscope

Nanoscale optical probes for use with nanoscale optical microscopy are disclosed herein. A nanoscale optical probe for use with a near-field scanning optical microscope includes an inner conductor having a top end, a bottom end, and a body; a dielectric material engaging the inner conductor; and an outer conductor engaging the dielectric material, wherein the inner conductor is longer at a tip surface of the probe than the dielectric material and the outer conductor.
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Graphite Layers

The present invention relates to a process for preparing graphite layers, comprising the step of heating at least one monolayer with low molecular weight aromatics and/or low molecular weight heteroaromatics crosslinked in the lateral direction under reduced pressure or inert gas to a temperature of > 800 K, and to graphite layers which are obtainable by this process.
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Layer system based on a high magnetic field or semiconductor-hybrids, comprises layers of a half-metallic ferromagnet, in an alternating arrangement, and a semiconducting compound, or a semiconducting

Layer system based on high magnetic field/semiconductor-hybrids, comprises one or more layers of a half-metallic ferromagnet, in an alternating arrangement, and a semiconducting compound, or a semiconducting non-stoichiometric compound. Layer system based on a high magnetic field/semiconductor-hybrids, comprises one or more layers of a half-metallic ferromagnet with Heusler structure of formula (X 2Y1Z) (I) or (XY1Z) (II), in an alternating arrangement, and a semiconducting compound with Heusler
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Fully Crosslinked Chemically Structured Monolayers

The present invention relates to a structured monolayer, which is composed of low molecular weight aromatics and in the lateral direction of fully networked, with the mono-layer on one of the two surfaces of a pattern of functional groups, a method for producing such a structured monolayer and their use.
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Spectroscopic Imaging Microscopy

Disclosed herein are systems that include: (a) an objective lens system configured to collect light from a sample; (b) a first aperture positioned to allow a portion of the collected light received from the objective lens system to pass as input light; (c) a first lens positioned to transmit the input light received from the first aperture; (d) a dispersive element configured to spatially disperse the input light received from the first lens in a first plane; (e) a second lens positioned to tran
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Method for Imaging on Thin Solid-state Interface Between Two Fluids

Described herein is a fluid cell for an optical microscopy tool having a solid state membrane having a first side and a second, opposing side; a first fluid chamber comprising a first fluid having a first refractive index located on the first side of the membrane; and, a second fluid chamber comprising a second fluid having a second refractive index located on the second side of the membrane, the second refractive index being different than the first refractive index. Also described herein is a
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Production of polyazol composites

Producing polyazole-composite (I) from polyazole homopolymers and/or polyazole-copolymers by a polycondensation reaction of a monomer A comprising hydrazine and/or its derivative and monomer B comprising dicarboxylic acid and/or its derivatives with a filler, comprises: (a) functionalizing the filler in a condensation agent, preferably phosphoric acid by heating under inert gas atmosphere; (b) mixing the monomers (A) and (B) with a mixture of step (a) to a solution; (c) heating the solution unde
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Automated System and Method for Obtaining Fully Focused Images with High-magnification Microscopes

Automated system and method for obtaining fully focused images with high-magnification microscopes. The methodology and instrumentation for obtaining images with high-magnification microscopes, focused throughout the focal range of interest, independently of the objective used and maintaining the chromaticity of the observed object completely stable. A methodology is used that makes it possible to obtain partially focused images at different objective/object distances for subsequent extraction o
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Microscopy Device with Tuning Fork and Rectilinear Tip

The device has a tuning fork and a rectilinear tip attached to one tine of the fork, a surface for supporting objects to be analysed and means for holding and moving the fork, said means being positioned so that the tip is inclined with respect to the support surface, at an angle that enables exploration with a rectilinear tip without the fork coming into contact with the objects or the liquid in which said object may be submerged, at the same time allowing visual access to the position of the e
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Method of and Device for Preparing Samples for Microscopy

The invention relates to a method of and device for preparing samples for microscopy, in particular for cryo-electron microscopy. The method comprises the following steps, which steps are carried out at a temperature below the melting temperature of water: partially or wholly covering the sample with a liquid solution of an encapsulant in a solvent, and evaporating the solvent thus partially or wholly encapsulating the sample.
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System and Method for Performing Microscopy with Light Exhibiting an Orbital Angular Momentum

A microscopy system is provided comprising a light source for generating a first light beam, a sample area for accommodating a sample to be examined, a detector for detecting a second light beam generated by the sample in response to the first light beam and an optical assembly for focusing the first light beam on the sample area and for focusing the second light beam on the detector. The light source is arranged for generating the first light beam with an orbital angular momentum. The system ma
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MRFM method

A method of magnetic resonance force microscopy for which spins are flipped of nuclei or electrons in several discrete volumes of the sample simultaneously. This is accomplished by superposition of different radiofrequency components, each one associated with a specific volume. The method relies on the proportional excitement of the resonance frequency in different hemispherical volumes having differen field strengths depending on distance from the cantilever tip.
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Method for Imaging an Object

The invention relates to a method for imaging an object, comprising the illumination of the object, and the detection of light coming from an area where the object is located and, based on the detected light, forming the image, with the illumination of the object taking place by distinguishing image elements in an imaging plane or space, and by separately illuminating the object parts corresponding with these image elements, while simultaneously registering the applied illumination dose of these
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Atomic Force Microscopy Probe

A probe for atomic force microscopy (SM) comprising a micromechanical resonator (RMM) and a tip for atomic force microscopy (P1) projecting from said resonator, the probe being characterized in that: it also includes means (EL1) for selectively exciting a volume mode of oscillation of said resonator (RMM); and in that said tip for atomic force microscopy (P1, P1') projects from said resonator substantially in correspondence with an antinode point (PV1) of said volume mode of oscillation. An atom
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Microscopy Control System and Method

A method for controlling laser scanning microscopy of a probe comprising at least one cell is disclosed. The method comprises the steps of acquiring at least one initial image of the probe and identifying at least one cell within an initial probe image. Using a pre-defined grammar, a first set of scanning mode parameters for monitoring the cell(s); a first set of trigger parameters including at least one physiological parameter defining an event in the cell(s); and a second set of scanning mode
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Linear Mode-locked DFB-fiber Laser with Repetition Rate Control

An embodiment of the invention relates to a multi-segment all-fiber laser device (10). The device includes a first active fiber laser segment (20), a first grating (25), a second grating (35), and a gain-phase coupling fiber segment (40) arranged between the first and second gratings, said gain-phase coupling segment providing coupling of gain and phase between said first and second gratings. The second grating may be provided in a second active fiber laser segment (30) and the phase may be adju
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Archaeal Plasmid Vector System

The present invention relates to an archaeal plasmid vector system comprising: I) one or more selectable marker gene(s) for selection in archaea, and II) at least one component selected from the group consisting of: a) an archaeal origin of replication, b) a homology region to an archaeal chromosome, c) a gene coding for a molecule conferring the ability to integrate the vector into an archaeal chromosome, and d) the gene orf904; wherein the genes of the plasmid vector do not allow an assembly o
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Bubbles and Method for Producing and Manipulating Bubbles

The invention relates to a bubble (2), particularly a vesicle or fluid cell, having a sheath (4), at least one liquid (6) trapped in the sheath (4), and at least one magnetic particle (8) trapped in the sheath (4), preferably a plurality of trapped magnetic particles (8). The invention also relates to a method for producing and manipulating the bubbles (2), and a device for this purpose.
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Digital Staining for Histopathology

Background 99.9 % of cancer cases are diagnosed and monitored by histopathological assessment of a biopsy sample. The presence, concentration and distribution of biological molecules (such as nucleic acid, protein or lipids for example) can be determined by selecting a specific combination of chemical stains and fixatives. A commonly used stain in histopathology is hematoxylin and eosin (H&E) which detect nuclei and cytoplasmic components of tissue, respectively (Figure 1). A well-trained hist
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Confocal Microscope with 2-D Array of LEDs

Background Confocal microscopes can provide 3-dimensional (3D) images with superior contrast and depth resolution compared to conventional wide-field microscopy because they reject the out-of-focus light. This makes them the tool of choice for advanced laboratory imaging, e.g. for life sciences or industrial inspection applications. In most confocal microscopes, illumination is provided by a scanning laser beam, requiring high-speed optomechanics that add significant complexity and cost to the
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Digital Manipulation Device for Navigating Virtual Microscopy Slides

Abstract (Set) The invention is a device which translates the movement of a ?dummy? slide on the stage of a microscope by a pathologist into movement of the digital image on the screen. This allows for a pathologist to quickly scan and diagnose the patient in a manner which is consistent with the skill-set they have been taught previously. The invention also eliminates the constant ?drag-and-click? that is associated with currently manipulating digital images of slides. Description (Set) P
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