Tools Patents for Sale or License

Multi-Purpose Paint Can Tool and Method

Product is called Paint Can Pro. This product has the potential to forever change the way millions of people manage their one-quart and one-gallon size paint cans. The tool is simply that unique and useful! Paint Can Pro virtually eliminates the typical “paint can hassle and mess” that always seems to be a part of painting, staining, varnishing or lacquering projects. Here's how it works: 1 — Use the built-in lid opener to open paint can without deformation of the lid edge/rim
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Computer Controlled Numerical Drop Saw

The purpose of the computer controlled numerical drop saw (cutter) is to accurately make two or more cuts in an elongate member, such as for making frames, especially complex frames with multiples members meeting at irregular angles, for example, joins for roofing timbers and other construction members. Also, for making one or more cuts at opposite ends very accurately, especially for a workpiece that has a round cross-section, although suitable for use with other cross-section workpieces, inclu
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Portable and Foldable Lift

The portable foldable lift is a lightweight lifting device that mounts to the tailgate of a pickup truck. It can also mount to the underside of a workbench. The lift collapses and stows nicely while not in use, and can quickly be deployed and set up in seconds allowing the user to load as much as 300 lbs to the bed of a truck or workbench using an 18 volt battery or the power source from the trailer light connection. It takes up minimal bed space and stays attached to the tailgate while stow
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Reciprocating tool, attachment, assembly and methods

an off-set saw blade attachment and shear attachment for Reciprocating saws that can be built into the housing or used as an attachment for various other saws.
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Padlock Saver

The Padlock Saver was created to cover a padlock and to help eliminate the frustrations involved in dealing with padlocks exposed to the environment. We all know that padlocks rust, corrode and freeze which usually leaves us no choice but to cut them off. The Padlock Saver will cover your padlocks and help protect it from the elements of rain, freezing rain, snow, the sun and UV rays. The Padlock Saver will help to prevent your padlocks from freezing and rusting. 8,438,884
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Band Clamp Closure Device

Band Clamp Closure Device: Abstract: A combined hammer and snip for use with strip metal banding is disclosed. The improvement consists of a protrusion attached to an arm of a pair of tin snips, allowing quicker and more positive securing of band clamps. The protrusion also allow for cutting sheet metal with less effort than a conventional pair of snips.
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Bookmarking FLEXOMETRO tipped built.

Flexometro con una punta de marcar desplegable sujeta a la carcasa, una vez abierta nos permite hacer diferentes marcaciones con solo un giro de muñeca. Es ideal para todo el sector de la construccion y en especial para el ramo del metal. Esta idea surgio de una necesidad, mi profesion es la de Herrero y con este invento se mejora el tiempo del proceso de marcado un 200% Traduccion google Tape measure with a point of marking down menus subject to the housing, once opened allows us to do
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Langaretti Scissors to Peel Shrimp

Very useful invention in the kitchen, designed to peel prawns and the like, is curved to facilitate entry into the body of the crustacean leaves, the lower blade takes a parallel arpon that handles click and hold the meat while doing the cutting operation
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Gardening Refuse Container

An improved waste receptacle with an upper and a lower handle that facilitates easy lifting and carrying of heavy loads without having to overextend to the bottom of the container for the purpose of lifting. With the second handle being located towards the lower portion of the receptacle, a more comfortable grip and posture can be achieved during tedious lifting and carrying tasks. Also, a scooping surface eliminates the need for a leaf scoop by merely tipping over the receptacle and raking
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Door and sheet material transporter

An apparatus to aid in the moving and transportation of heavy doors or large sheet-type materials comprises a pair of joined “L”-shaped brackets mounted upon a folding hinge. The hinge allows the weight of the carried material to fold the apparatus inwardly thus securely gripping the loaded items within. Each “L”-shaped bracket comprises a front plate which secures the load in a lower corner area while allowing the user to lift and support the other bottom corner. The apparatus is suppor
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Door Hanging Tool

I am a retired Master Carpenter with a Structural Engineering background. I am seeking offers to Manufacture/Sell/Distribute my tool. I have developed a NEW Plumb-Level Tool for hanging pre-hung doors and existing doors. Patent No. 8418375. For a complete discription go to (USPTO.GOV) search patent number.. I have a proto-type and have used it in my contracting business with great success. Other contractors and carpenters ask where I got it. After that I put it away.
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Instant Action Adjustable Wrench/Quick Adjusting Wrench/Quick Adjustable Spanner

This revolutionary tool is very unique, it is an ideal substitute to existing variety of adjustable wrenches with fast adjusting function having the capability to replace completely the traditional adjustable wrench in coming years, it has no difference comparing traditional adjustable wrench at first glance, meets the traditional consuming concept of an adjustable wrench - solid and more reliable, so this product will be well accepted quickly by markets as we believe. I.P. Status: patented
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Shovel Lifting/Throwing Device

The first self lifting snow shovel in the world is in front of you! So please take a look you will be surprized what this actually is. Shoveling snow consists of three actions pushing, lifting and throwing. This shovel uses the one action of pushing to lift and throw the snow in one smooth pushing motion, the need to lift is done for you as user pushes and accumulated a load the shovel can do nothing but lift it happens automaticaly, The act of lifting is totally eliminated. This is th
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Dust Collector for Portable Drill

The "Clean Driller" is a device for capturing drilling tailings, dust and pollutants normally discharged into the environment during normal drilling operations. The patent covers two variants of the device for use in either industrial or home drilling applications. A comprehensive patent profile is available on request.
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Method and Apparatus for Sorting Particles

Methods and an apparatuses are provided for sorting particles according to the shape thereof in at least two classification stages in a chronological or spatial sequence.
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System, Method, and Apparatus for Suction Gripping

A suction gripper includes a cup member, a suction port, and a valve. The cup member has inner and outer surfaces defining an opening such that the inner surface defines an inner cavity. The suction port provides suction. The valve in is fluid communication with the suction port and the inner cavity of the cup member to modify the suction therebetween. The valve is operatively coupled to the cup member and is adapted to passively actuate in response to an applied force to the cup member.
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Steerable Multi-linked Device Having a Modular Link Assembly

A steerable multi-linked device. The device includes a first multi-linked mechanism and a second multi-linked mechanism. At least one of the first and second multi-linked mechanisms is steerable and includes a modular link assembly at an end thereof. The modular link assembly includes a base, and a tip removably connected to the base.
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Method and Apparatus for Jet-assisted Drilling Or Cutting

An abrasive cutting or drilling system, apparatus and method, which includes an upstream supercritical fluid and/or liquid carrier fluid, abrasive particles, a nozzle (10) and a gaseous or low-density supercritical fluid exhaust abrasive stream. The nozzle (10) includes a throat section (2) and, optionally, a converging inlet section (1), a divergent discharge section (3), and a feed section (12).
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Method for Finishing a Surface of a Workpiece By Means of Forming a Third Body

The invention relates to a method for finishing a surface of a workpiece by means of forming a third body utilizing a metal-cutting surface processing tool. The invention is characterized by the combination of the following process steps: providing a surface processing tool having a blade, the blade edge rounding rss of which approximately corresponds to a cutting depth h by which the blade penetrates into the tool during the surface processing, contacting the surface processing tool at the surf
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Method for Finishing a Surface of a Workpiece By Means of Forming a Third Body

The invention relates to a method for finishing a surface of a workpiece by means of forming a third body utilizing a metal-cutting surface processing tool. The invention is characterized by the combination of the following process steps: providing a surface processing tool having a blade, the blade edge rounding rss of which approximately corresponds to a cutting depth h by which the blade penetrates into the tool during the surface processing, contacting the surface processing tool at the surf
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System and Method for Smoothly Inverting One Or More Faces of a Cubical Device

A system and method for inverting a cubical device 100 that inverts one or more faces of the cubical device 100 in a single fluid motion. In an embodiment, the cube faces are split in two face piece assemblies 210, in an alternative embodiment faces have only one invertible section 802, 702. The face piece assemblies 210 are initially held by cubical device 100 with a particular side facing inward. Operating the cubical device 100 causes one or more face piece assemblies 210, 803 to expand out f
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Methods for Forming Metal-polymer Hybrid Tooling for Forming Parts Having Micro Features

A method (10, 100) for forming metal-polymer hybrid tooling includes patterning a surface of a silicon wafer (20, 420), depositing a polymer material (30, 430) onto the patterned features of the surface of the silicon wafer to form a polymer layer having a reverse of the patterned surface the silicon wafer, removing the patterned polymer layer to expose a patterned polymer layer surface, depositing a metallic layer (30, 430) on the patterned polymer layer surface, and wherein the deposited metal
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Microwave Plasma Sintering

A method for producing an article having a composite surface including abrasive particles, comprises pressing a mixture of abrasive particles and a metal binding matrix to form a body, loading said body into a microwave plasma chamber, at least partially evacuating said chamber, and sintering the body in a microwave plasma for a period of time to produce said article. The method optionally includes a further method step, in which after the evacuation of the chamber a reducing or an inert gas (e.
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A Cutting Tool

The present invention provides a cutting tool (10) which comprising a drill bit (12) having an integrated deburring tool (14) or tip which is displaceable between an extended and retracted position in order to enable both drilling and deburring operations to be carried out using a single tool, and which incorporates a number of features to increase the speed at which the deburring tip extends and retracts.
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A Speech Valve, a Tool for Facilitating Insertion of a Speech Valve and a Tool for Holding a Speech Valve

A tool (106) for facilitating insertion of a speech valve (10) with a flexible retention flange (56) into a fistula between the trachea and the oesophagus of a human patient, having a wall (108) curved to define a passage (116) having opposed open first and second passage ends and an axis extending therebetween, said wall (108) having an external surface (118) insertable into a fistula between the said trachea and oesophagus and defining a slot (110) which extends from the passage (116) to the e
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Injection Molding Tools with Micro/nano-meter Pattern

The present invention relates to methods for embedded a micrometer and/or nanometer pattern into an injection molding tool. In a first main aspect, a micro/nanometer structured imprinting device is applied in, or on, an active surface so as to transfer the micro/nanometer patterned structure to the tool while the imprinting device is, at least partly, within a cavity of the injection molding tool. In a second main aspect, a base plate with a micro/nanometer structured pattern positioned on an up
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Pressure sensor apparatus and pressure sensor housing

A pressure sensor apparatus and a pressure sensor housing are provided that are capable of preventing the occurrence of frozen moisture, swelling of a gel-like coating member and damage of a pressure sensor element (201) without accumulating moisture, oil, gasoline or the like on a protective wall (108) even when the pressure sensor apparatus is disposed obliquely. The protective wall (108) prevents entry of foreign matter into the pressure detection chamber (102), or a pressure sensor housing o
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Integrated sensor including a pressure sensor and a temperature sensor

An integrated sensor includes a pressure sensor element integrated with a temperature sensor element (109). When the sensor is attached to an object of attachment (200) at a mounting position at an angle of ¸ rq degrees with respect to an ideal attachment position, in which a central axis (c) of at sensor element body (109a) of the temperature sensor element (109) is disposed perpendicular to a direction in which a gas to be measured passes through the object of attachment, an inclination angle
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Medical Instrument for Grasping an Object, in Particular Needle Holder

A medical instrument for grasping an object, in particular a surgical needle holder, including an elongated shaft, two jaw parts arranged at a distal end of the shaft, at least one of the jaw parts being pivotable with respect to the other of the jaw parts between a grasp state for grasping the object between the jaw parts and a release state for releasing the object. A handle is arranged at a proximal end of the shaft and has at least one operating element for moving the at least one pivotable
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Cutting Device for Cutting Graphene and Method for Cutting Graphene Using a Cutting Device

The invention relates to a cutting device for cutting graphene, comprising a receiving area (10) that is designed to receive the graphene (19) for cutting, a cutting element (12) charged with a catalytically active material at least in the region of a cutting tip, a displacement unit that is designed to displace the receiving area (10) and the cutting element (12) with the cutting tip in relation to one another, and a heating device (14) that is designed to provide thermal energy for a catalytic
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Polishing Apparatus

A polishing apparatus for polishing an end edge of a work piece by bringing a bristle tip of a polishing brush into contact with the end edge of the work piece as the bristle tip passes the end edge of the work piece includes a support plate having a through hole into which the polishing brush is inserted and a suppression portion that is provided at the support plate and suppresses a deformation of the bristle tip of the polishing brush when the work piece is polished. The invention relates
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Method and Apparatus for Determining the Kinetics of Solution Reactions by Mass Spectrometry

The technology involves a novel flow mixing device which can be coupled to electrospray ionization or other ionization sources. Liquids are mixed in a “tee” with low dead volume to initiate a chemical reaction. The tee is connected to the ion source by a reaction capillary. The apparatus is configured such that the reaction time can be determined. This can either be by way of a capillary of known length and volume extending from a reaction tee or other mixing device, so that the reaction tim
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Using Wearable Biometrics for Continuous Automated Authentication

Biometrics use biological features such as fingerprints to determine an individual’s identity by comparing the observed fingertip patterns to a previously stored pattern. Biometrics are useful for controlling access to devices - such as laptops - or to facilities. One drawback, however, is the user-intrusive action required, such as placing a finger on a sensor for scanning or positioning the eye close to an iris scanner. The intrusiveness of a biometric scan can be especially cumbersome durin
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Radio Frequency Beacon

One use for radio frequency beacons is to track the position of spacecraft that are in orbit outside the earth's atmosphere. It is important to know the position of such spacecraft as exactly as possible in order to aim ground based systems that are in communication with the spacecraft. Position information is also important to accurately interpret scientific data collected by spacecraft instrumentation for transmission back to earth. RF beacons deployed in space face tougher performance obs
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Damping Gyrometer

A damping gyrometer comprised of at least two and preferably four rotating paddles attached to a common central elevated low-friction pivot point via rising radial arms. A stand with a concave glass element provides a low-friction support as a pivot point seat for the pivot point. All elements of the apparatus are non-conductive. Once set into motion, the only force acting on the gyrometer are the pivot point friction and the damping effects of the medium in which it spins. A laser beam and phot
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Expendable Beam Transmissiometer

This invention meets the needs of those expressing an interest in inexpensive sensor measuring tools for the measurement of water quality, clarity and environmental ground truth measurements in support of field experiments. The sensor can be launched using any of the three inch signal ejectors and will float to the surface where the probe is then released and begins “profiling” the water. This novel invention provides an unmatched combination of performance, miniaturization (in volume and we
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Heated Element Velocimeter

The present invention is a heated element sensor for detecting the flow rate of a fluid or other physical characteristics of a fluid. The invention teaches driving the thermo-resistive element along a profile having at least two states and measuring the power and temperature of the sensor at each state. In this way a dissipation coefficient can be determined and fluid flow and other physical characteristics determined without the need for ambient temperature to be determined.
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A Successful Wire Bonding Technique for CZT Strip Detectors and Detector Arrays ()

Abstract: The National Aeronautics and Space Administration (NASA) seek partners to further develop solid-state cadmium zinc telluride (CZT) detectors and transfer this technology to commercial applications.
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Control System for Prosthetic Devices (MSC-21941)

Abstract: The invention is a myoelectric prosthesis control system for below-the-elbow amputees. Although many prosthetic devices have been developed, including computer controlled "bionic" or hydraulically actuated devices, these devices do not provide user feedback.
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Quick Connect Fastener (MFS-28833)

Abstract: NASA is offering a quick-connect, slow-disconnect nut and bolt for technology transfer. The designs of the nut and the bolt are available together or separately. The design permits the nut to be installed simply by pushing it onto a standard bolt or threaded stud. Once installed, it can be removed only by unscrewing it in the manner of a conventional nut. The bolt operates in a similar manner. It is installed by pushing it directly into the hole on a nut. It is unscrewed in the same m
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Automated, Inexpensive, Liquid Delivery Device for the Robust, Reproducible, Efficient, Multiplexed and Gentle Processing of Affinity Matrices

Scientists at JHU have developed an inexpensive device for the automated delivery of unlimited solvent volume in a manner that provides constant, gentle, suspension of the column/support matrices (including affinity, ion exchange, reversed phase matrix, etc), without packing the matrix (e.g. beads) against the supporting filter or mechanically crushing them. The device allows for automated, highly reproducible and efficient processing of affinity matrices in a single and or multiplexed fashion.
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Specific Absorption Rate (SAR) Dosimeter for RF Power Deposition in MRI

The present invention addresses the critical need for direct and independent SAR by providing the first dosimeter for MRI which directly measures standard average head and body SAR. The device uses a transducer placed in the scanner, comprised of induction looping a resistive load and a small MRI set-up sample. The voltages induced in the loops are measured and calibrated to provide direct measures of the average SAR, independent of the scanner Devices that are tested to be safe at a specified s
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A Novel Approach to Peptide/Protein Chip Fabrication

This technology describes improved methods for stalling ribosomes during protein translation and capturing the nascent polypeptides through puromycin which is grafted at the end of an oligo immobilized on a solid phase. Existing technologies include an inefficient ligation step to incorporate puromycin onto the nucleic acid molecule, which is not required with this approach. This technology eliminates the need for the time consuming and labor intensive step of cloning ORFs into expression vector
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pT2cfosGW

A current hypothesis is that sequences conserved over greater evolutionary distances are more likely to be functional than sequences that are less well conserved. In order to identify non-coding regulatory sequences, scientists at JHU developed a novel reporter vector based on the Tol2 transposon, and permitting reporter gene expression from a minimal promoter. Description (Set) Proposed Use (Set) This invention will facilitate identification of important functional elements in the DNA sequ
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Emission Ratiometric Indicators of Phosphoinositides

cellular processes via activation of the serine/threonine kinase, Akt. JHU inventors have developed an emission ratiometric reporter, InPAkt, as research tool for monitoring the production and degradation of PIP(3,4)2 and PIP3 in living cells after transfection with plasmid constructs encoding the reporter protein, using a Fluorescent Resonance Energy Transfer (FRET) assay. The reporter molecule comprises a pair of fluorescent proteins linked by a region containing a phosphoinositide binding dom
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Olfactory Receptor I7 Targeted O/E3 Knockout Mice

The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH) transcription factors has been implicated in olfactory system gene regulation, nervous system development and B-cell differentiation. Researchers at Johns Hopkins have generated a genetic knockout transgenic mouse in which the O/E3 gene is replaced with coding sequences from an odorant receptor. Description (Set) Proposed Use (Set) This mouse line provides an important research tool for studying the function of the O/E
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Rapid Identification of Microbial Genotypes and Phenotypes

Apparatus, systems, and methods for detecting, screening and sampling of cells are disclosed. Patent (Set) PCT/US05/003369
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Anti-rat Melanopsin N-terminus Antibody

Research tool that can be used for immunohistochemical labeling of melanopsin-containing ganglion cells in rodent models. Description (Set) Proposed Use (Set) Immunohistochemistry, Western blot analyses
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Time-of-Flight Mass Spectrometer Combining Fields Non-linear in Time and Space

This companion to project DM4077 adds time dependency to the non-linear electostatic fields in a time-of-flight mass spectrometer. The specific aim is the development of miniaturized laboratory and diagnostics instruments with high resolving power. Description (Set) Proposed Use (Set) Research instrumentation, analytical instrumentation, proteomics, homeland security Patent (Set) WO 03/103008
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N-Methyl-D-aspartate (NMDA) Receptor NR1 Subunit Polyclonal Antibody

JHU scientists have developed a polyclonal antibody to the NR1 Subunit of the N-Methyl-D-aspartate (NMDA) Receptor. Proposed Use (Set) This technology encompasses an antibody specific for the NR1 Subunit of the NMDA Receptor. It has the potential to be commercialized as a biomarker for therapeutic, prophylactic or diagnostic use.
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GDF-1 Knockout Mouse

Transgenic knockout mouse serves as a useful tool to identify the developmental activity associated with the expression of the growth/differentiation protein, GDF-1. Description (Set) Proposed Use (Set) Diagnostic application for left-right pattern pathologies in birth defects and the upstream regulatory impact of this gene upon those downstream early in the development pathway.
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Yeast Strain S288C

A yeast strain based on Saccharomyces cerevisiae S288C in which commonly used selectable marker genes are deleted by design, dependent upon the yeast genome sequence of interest. Description (Set) Proposed Use (Set) Deletion mutations are valuable because they never revert back to the wild-type phenotype. This strain is useful because it minimizes or eliminates the homology to corresponding marker genes in many commonly used vectors, without significantly affecting adjacent gene expression.
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ATM Kinase Assay

The present invention relates to identification of the consensus sequence phosphorylated by ATM kinase. This, in turn, permitted identification of ATM kinase target proteins, and development of a convenient assay system for ATM kinase phosphorylation using fusion polypeptides as substrates. The assay system is adaptable to screening for ATM modulators, particularly inhibitors. In a specific embodiment, the substrate recognition sequence and mutagenized variants of this sequence were incorporated
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rRNA Mutagenesis

The ribosome is the biological machine that has evolved to generate encoded polymers. The development of a novel in vitro selection procedure for evolving the ribosome to recognize and perform chemistry on altered substrates is described. Specifically, the in vitro selection system allows for the isolation of 23S rRNA derivatives that are functionally enriched for catalysis on altered substrates. Redirection of the ribosomes ? substrate specificities will allow for the generation of encoded, non
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Method and Apparatus for Correction of Initial Ion Velocity in a Reflectron Time-of-Flight Mass Spectrometer

Theoretical treatment of ion focusing in a time-of-flight mass spectrometer that considers complex and/or non-linear fields in the source, extraction and reflectron regions as a means for providing high order focusing. Description (Set) Proposed Use (Set) Time-of-flight mass spectrometer, research instrumentation Patent (Set) 6,365,892;
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Hybridoma H5C6

A murine hybridoma cell line that secretes a monoclonal antibody (IgG1, k) against hum CD63. Description (Set) Proposed Use (Set) Useful tool for immunophenotyping, immunohistochemistry, immunoprecipitation, Western blot analysis, and immunocapture assays.
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Method of Isolation of Ions in an Ion Trap with Increased Resolving Power

An approach to isolation of ions over a short mass range or single isotopic species using a stored waveform inverse Fourier transform (SWIFT) excitation, for use in an ion trap mass spectrometer. Description (Set) Proposed Use (Set) ion trap mass spectrometers, biological research, Patent (Set) 5,696,376; WO 97/44814
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RL12, RL1, RL13, RL2 Monoclonal Antibodies

RL1, mouse monoclonal IgM that recognizes a group of eight O-linked glycoproteins of the nuclear pore complex, is a specific marker for the nuclear pore complex in species from yeast to humans; RL2, mouse monoclonal antibody that recognizes O-linked N-acetylglucosamine on a large number of cellular proteins, including the 8 nuclear pore complex glycoproteins recognized by RL1, is useful for general detection of proteins modified by O-linked N-acetylglucosamine; RL13, mouse monoclonal IgG recogni
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A biochemical method for specific protein labeling

UbiquiTAG is a novel platform by which small molecule tags (e.g. biotin and fluorescent probes) can be selectively transferred onto specific protein substrates via the ubiquitination pathway. This pathway-enabled selective labeling of ubiquitin subs trates could serve as a means for generating a variety of useful proteomic tools. The high selectivity, broad scope and non-reactive nature of UbiquiTAG makes it an ideal platform for studying protein dynamics and function in vivo. Categories: Re
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tRNA aminoacylation on ribozyme-immobilized reins

This invention is part of a set of novel processes that isolate, concentrate and reprogram enabling catalysts in protein synthesizing biochemical reactions. These help synthesize in vitro targeted proteins (natural/artificial) with structural and fun ctional traits dictated by application necessity. Earlier inventions no. 5590 and 5610 described a bi-functional ribozyme that aminoacylated tRNA in a pool. Current methods for aminoacylation use a ribozyme that can be employed only once and also ta
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Method for Ribozyme-catalyzed tRNA aminoacylation (2)

This invention is part of a set of novel processes to isolate, concentrate and reprogram enabling catalysts in protein synthesizing biochemical reactions. These help synthesize in vitro targeted proteins (natural/artificial) with application specific traits. Invention no. 5590 described a bifunctional ribozyme (and a superior process to prepare it) to catalyze in vitro synthesis of natural/unnatural aminoacyl-tRNA. This invention describes the synthesis of any desired aminoacyl-tRNA with the sai
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Aminoacylation of Transfer RNA by Ribozymes (see also R-5610)

This invention is part of a set of novel processes for isolation, concentration and reprogramming of enabling catalysts in protein synthesizing biochemical reactions. These help synthesize in vitro targeted proteins (natural/artificial) with applicat ion dictated traits, through in vitro processes. Natural enzymes are incapable of catalyzing the synthesis of unnatural aminoacyl-tRNA, an important participant in protein synthesis. This invention describes a bi-functional ribozyme isolated that en
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DEVELOPMENT OF NEW ANIMAL MODEL FOR HYPERACTIVE DISORDER AND SCHIZOPHRENIA. (Combined w/R-5825)

The study of schizophrenia and neurodegenerative diseases such as Parkinson’s Disease (PD) and the subsequent development of therapeutic agents to combat these diseases rely upon accurate non-human models that mimic the pathogenesis of their human co unterparts. As the current schizophrenic and PD models fail to simulate all of the pathogenic, histological, biochemical and clinical features of their respective disease, their value remains limited. A University at Buffalo researcher has develop
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Rk-GFP Transgenic mouse with Rhodopsin kinase promoter driven Green Fluorescent protein with green photo receptors

This technology encompasses a transgenic mouse model, Rk-GFP, for the study of photoreceptor-specific gene expression in the retina. Unlike the currently available transgenic mice used for this purpose, the Rk-GFP transgenic mouse model contains ver y little, if any, exogenous DNA sequences. Instead, it incorporates a very short human DNA sequence which was derived from the region upstream of rhodopsin kinase and has demonstrated enhancer/promoter properties. Linking Green Fluorescent Protein (G
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tRNA aminoacylation on ribozyme-immobilized reins

This invention is part of a set of novel processes that isolate, concentrate and reprogram enabling catalysts in protein synthesizing biochemical reactions. These help synthesize in vitro targeted proteins (natural/artificial) with structural and fun ctional traits dictated by application necessity. Earlier inventions no. 5590 and 5610 described a bi-functional ribozyme that aminoacylated tRNA in a pool. Current methods for aminoacylation use a ribozyme that can be employed only once and also ta
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Discovery of an Integrative Nuclear FGFR1 Signaling (INFS) pathway that controls neuronal growth and survival - development of new experimental model and treatments for the Parkinson Disease (PD).

As current animal models of Parkinson's Disease (PD) fail to simulate all of the pathogenic, histological, biochemical and clinical features of the disease, their value remains limited. Therefore, it is vital that models be developed both for a be tter understanding of the pathogenesis of PD and for discovering more effective pharmacotherapeutics to treat PD. The inventor has discovered a new signal transduction pathway named Integrative Nuclear FGFR1 Signaling (INFS) through which diverse ex
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Method for Ribozyme-catalyzed tRNA aminoacylation (2)

This invention is part of a set of novel processes to isolate, concentrate and reprogram enabling catalysts in protein synthesizing biochemical reactions. These help synthesize in vitro targeted proteins (natural/artificial) with application specific traits. Invention no. 5590 described a bifunctional ribozyme (and a superior process to prepare it) to catalyze in vitro synthesis of natural/unnatural aminoacyl-tRNA. This invention describes the synthesis of any desired aminoacyl-tRNA with the sai
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Aminoacylation of Transfer RNA by Ribozymes (see also R-5610)

This invention is part of a set of novel processes for isolation, concentration and reprogramming of enabling catalysts in protein synthesizing biochemical reactions. These help synthesize in vitro targeted proteins (natural/artificial) with applicat ion dictated traits, through in vitro processes. Natural enzymes are incapable of catalyzing the synthesis of unnatural aminoacyl-tRNA, an important participant in protein synthesis. This invention describes a bi-functional ribozyme isolated that en
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Coordinate independent, consistent and high level dual-gene transgenesis from a single lentiviral vector

Expression of multiple genes within the same target cells is required for certain gene delivery and therapeutic applications. In spite of such need, reaching independent, coordinate and high level dual-gene expression is still a challenging task. Non -uniform transfer, promoter interference, and poor expression levels are only some of the problems associated with existing approaches to dual-gene transfer. Chemical and biological engineers at the University at Buffalo have developed a new approac
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Bridging Centrality: a Concept and Formula to Identify Bridging Nodes in Scale-free Networks

The invention relates to a novel essential component identification model, bridging centraility, based on information flow and topological locality in scale-free networks. Bridging centrality provides an entirely new way of scrutinizing network struc tures and measuring components' importance. The briding centrality can be applied to many real world networks, including biological networks, social networks and web networks. The nodes distinguished by bridging centrality are well located on conn
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Instant Action Adjustable Wrench with Real Anti Slip Gripping System

This invention consists of following features: a. Absolute Anti Slip Mechanism to protect from the damage of the work piece; b. Instant Adjustment to Grip & Release by Thumb Pushing; c. Simple structure for earsier manufacturing; d. Less cost of production is required.
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Sub-5 Nanosecond Neutron Generator for Detection of Explosives

APPLICATIONS OF TECHNOLOGY: - Screening of luggage and cargo for explosives and fissile material - Gamma ray and neutron detection ADVANTAGES: - Produces short 5 nanosecond neutron pulses - Minimizes alignment problems - Reduces RF input power requirement - Removes spurious background particle generation almost completely - Drastically reduces beam power deposited into beam dump, decreasing cooling requirements ABSTRACT: Using a novel source and extraction geometry, Ka-Ngo Leung, Sami H
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Flooring Device for Postioning on Joists

A FLOOR APPARATUS FOR FORMING A FLOOR OVER EXPOSED JOISTS IN AN ATTIC,THE APPARATUS COMPRISING: A PLURALITY OF SUBSTANTIALLY RIGID PANELS ARRANGED ADJACENT TO EACH OTHER IN A SERIES, EACH OF THE PANELS HAVING A TOP SIDE, A PAIR OF RELATIVELY LONGER AND OPPOSITE SIDE EDGES: AND CONNECTING EACH PANEL OF THE PLURALITY OF PANELS TO AN ADJACENT PANEL IN SERIES, THE CONNECTING MEANS PERMITTING ADJACENT PANELS OF THE SERIES TO PIVOT ABOUT A PIVOT AXIS WITH RESPECT TO EACH OTHER.WHERE IN THE SERIES OF P
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LABELIT – Software for Macromolecular Diffraction Data Processing

APPLICATIONS OF TECHNOLOGY: - Automatically index X-ray diffraction images - Quickly summarize the diffraction quality - Determine Laue symmetry from a partial dataset ADVANTAGES: - Makes visual inspection of images unnecessary - Better algorithms for spot picking - More robust indexing procedures - Suitable for automatic scripting without requiring graphical interaction ABSTRACT: The Lawrence Berkeley Laboratory Indexing Toolbox (LABELIT) expedites the in-house processing of x-ray diffr
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Human Papillomavirus 6

TECH FIELD(S) Research Tools FEATURES Human Papiilomarvius 6 gene sequence and expression construct.
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Fluorescent in Situ PCR

TECH FIELD(S) Research Tools-Diagnostics FEATURES In situ PCR (polymerase chain reaction) has become a powerful molecular tool in research as well as clinical practice. This technique has resulted in an increased understanding of infectious and neoplastic diseases and improvements in diagnosis of disease. In situ RT-PCR (Reverse Transcription- PCR) gives more detailed information by allowing for highly sensitive detection of low abundance gene expression in a given cell while providing ana
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Doxcycline-inducible and brain-specific HIV-1 Tat transgenic mice

TECH FIELD(S) Research Tool FEATURES Human immunodeficiency virus type 1 (HIV-1) Tat protein has been implicated in the pathogenesis of a number of AIDS-related disorders including HIV-induced neuropathogenesis. However, most of the studies demonstrating Tat neurotoxicity have been performed in vitro. The mechanisms of Tat neurotoxicity should be addressed in the context of a whole organism and in a manner that allows for characterization of pathologies specific to Tat expression in the br
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DNA and Protein Library Construction Methodology

A method for building and polymerizing artificial coding sequence (6-mers) for the creation of unique nucleic acids and proteins from a limited number of amino acids TECH FIELD(S) Research Tool FEATURES A method for producing novel libraries with limited amino acid diversity that contain structurally and biologically relevant nucleic acids and proteins. The method polymerizes six nucleotide (6-mer) codons; these duplexes are themselves multi-merized together. The resulting nucleic a
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De novo Peptide Sequencing Using a Covalent Derivatization Strategy

FEATURES Research Tool. The invention describes a dual labeling strategy that enhances the mass spectrometry analysis of peptides. A de novo sequencing method is described that utilizes both guanidination of lysine residues in conjunction with amidination of the N-termini of peptides to be analyzed by mass spectrometry. BENEFITS * The invention facilitates identification of N- and C-terminal fragment ions.
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Aryl and Vinyl Amination

FEATURES The invention provides methodology for carbon-nitrogen bond formation via vinyl or aryl amination. An sp2 hybridized radical is reacted with an azomethine moiety to form pyrrolidine and indole compounds. BENEFITS The invention provides a facile process for the syntheis of compunds having the pyrrolidine or indole subunit and is especially advantageous for compounds having acid or base labile functional groups and/or is comprised of chiral centers susceptible to acid/base epimeriz
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